The Biomedical Uses of Inositols: A Nutraceutical Approach to Metabolic Dysfunction in Aging and Neurodegenerative Diseases

Antonio J. López-Gambero; Carlos Sanjuan; Pedro Jesús Serrano-Castro; Juan Suárez; Fernando Rodríguez de Fonseca

doi:10.3390/biomedicines8090295

journal article Open Access Aug 20, 2020

The Biomedical Uses of Inositols: A Nutraceutical Approach to Metabolic Dysfunction in Aging and Neurodegenerative Diseases

Antonio J. López-Gambero

Carlos Sanjuan Pedro Jesús Serrano-Castro

Juan Suárez

Fernando Rodríguez de Fonseca

Biomedicines Vol. 8 No. 9 pp. 295 · MDPI AG

View at Publisher Save 10.3390/biomedicines8090295

Abstract

Inositols are sugar-like compounds that are widely distributed in nature and are a part of membrane molecules, participating as second messengers in several cell-signaling processes. Isolation and characterization of inositol phosphoglycans containing myo- or d-chiro-inositol have been milestones for understanding the physiological regulation of insulin signaling. Other functions of inositols have been derived from the existence of multiple stereoisomers, which may confer antioxidant properties. In the brain, fluctuation of inositols in extracellular and intracellular compartments regulates neuronal and glial activity. Myo-inositol imbalance is observed in psychiatric diseases and its use shows efficacy for treatment of depression, anxiety, and compulsive disorders. Epi- and scyllo-inositol isomers are capable of stabilizing non-toxic forms of β-amyloid proteins, which are characteristic of Alzheimer’s disease and cognitive dementia in Down’s syndrome, both associated with brain insulin resistance. However, uncertainties of the intrinsic mechanisms of inositols regarding their biology are still unsolved. This work presents a critical review of inositol actions on insulin signaling, oxidative stress, and endothelial dysfunction, and its potential for either preventing or delaying cognitive impairment in aging and neurodegenerative diseases. The biomedical uses of inositols may represent a paradigm in the industrial approach perspective, which has generated growing interest for two decades, accompanied by clinical trials for Alzheimer’s disease.

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Details

Published: Aug 20, 2020
Vol/Issue: 8(9)
Pages: 295
License: View

Authors

A

Antonio J. López-Gambero

Departamento de Biología Celular, Genética y Fisiología, Campus de Teatinos s/n, Universidad de Málaga, Andalucia Tech, 29071 Málaga, Spain; UGC Salud Mental, Instituto de Investigación Biomédica de Málaga (IBIMA), Hospital Universitario Regional de Málaga, 29010 Málaga, Spain

C

Carlos Sanjuan

EURONUTRA S.L., 29590 Málaga, Spain

P

Pedro Jesús Serrano-Castro

UGC Neurología, Instituto de Investigación Biomédica de Málaga (IBIMA), Hospital Universitario Regional de Málaga, 29010 Málaga, Spain

J

Juan Suárez

UGC Salud Mental, Instituto de Investigación Biomédica de Málaga (IBIMA), Hospital Universitario Regional de Málaga, 29010 Málaga, Spain

F

Fernando Rodríguez de Fonseca

UGC Salud Mental, Instituto de Investigación Biomédica de Málaga (IBIMA), Hospital Universitario Regional de Málaga, 29010 Málaga, Spain

Funding

Instituto de Salud Carlos III Award: DTS16/00115

Agencia Estatal de Investigación, Ministerio de Economía y Competitividad or Ministerio de Ciencia e Innovación and European Regional Development Funds-European Union (ERDF-EU) Award: RTC-2016-4983-1

Consejería de Salud y Familia de la Junta de Andalucía Award: NeuroRECA RIC-0111-2019

Cite This Article

Antonio J. López-Gambero, Carlos Sanjuan, Pedro Jesús Serrano-Castro, et al. (2020). The Biomedical Uses of Inositols: A Nutraceutical Approach to Metabolic Dysfunction in Aging and Neurodegenerative Diseases. Biomedicines, 8(9), 295. https://doi.org/10.3390/biomedicines8090295

The Biomedical Uses of Inositols: A Nutraceutical Approach to Metabolic Dysfunction in Aging and Neurodegenerative Diseases

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