journal article
Open Access
Dec 18, 2021
Pregnancy-Associated Plasma Protein (PAPP)-A2 in Physiology and Disease
Abstract
The growth hormone (GH)/insulin-like growth factor (IGF) axis plays fundamental roles during development, maturation, and aging. Members of this axis, composed of various ligands, receptors, and binding proteins, are regulated in a tissue- and time-specific manner that requires precise control that is not completely understood. Some of the most recent advances in understanding the implications of this axis in human growth are derived from the identifications of new mutations in the gene encoding the pregnancy-associated plasma protein PAPP-A2 protease that liberates IGFs from their carrier proteins in a selective manner to allow binding to the IGF receptor 1. The identification of three nonrelated families with mutations in the PAPP-A2 gene has shed light on how this protease affects human physiology. This review summarizes our understanding of the implications of PAPP-A2 in growth physiology, obtained from studies in genetically modified animal models and the PAPP-A2 deficient patients known to date.
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Cited By
39
Signaling Pathways of the Insulin-like Growth Factor Binding Proteins
Endocrine Reviews
Robert C Baxter · 2023
Metrics
39
Citations
92
References
Details
- Published
- Dec 18, 2021
- Vol/Issue
- 10(12)
- Pages
- 3576
- License
- View
Authors
Funding
Instituto de Salud Carlos III
Award: FIS PI19/00166 and PI19/00343
Spanish Biomedical Research Centre in Physiopathology of Obesity and Nutrition
Award: CIBEROBN/022
Cite This Article
Vicente Barrios, Julia A. Chowen, Álvaro Martín-Rivada, et al. (2021). Pregnancy-Associated Plasma Protein (PAPP)-A2 in Physiology and Disease. Cells, 10(12), 3576. https://doi.org/10.3390/cells10123576
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