Probiotics Mechanism of Action on Immune Cells and Beneficial Effects on Human Health

Chiara Mazziotta; Mauro Tognon; Fernanda Martini; Elena Torreggiani; John Charles Rotondo

doi:10.3390/cells12010184

journal article Open Access Jan 02, 2023

Probiotics Mechanism of Action on Immune Cells and Beneficial Effects on Human Health

Chiara Mazziotta Mauro Tognon

Fernanda Martini

Elena Torreggiani John Charles Rotondo

Cells Vol. 12 No. 1 pp. 184 · MDPI AG

View at Publisher Save 10.3390/cells12010184

Abstract

Immune cells and commensal microbes in the human intestine constantly communicate with and react to each other in a stable environment in order to maintain healthy immune activities. Immune system-microbiota cross-talk relies on a complex network of pathways that sustain the balance between immune tolerance and immunogenicity. Probiotic bacteria can interact and stimulate intestinal immune cells and commensal microflora to modulate specific immune functions and immune homeostasis. Growing evidence shows that probiotic bacteria present important health-promoting and immunomodulatory properties. Thus, the use of probiotics might represent a promising approach for improving immune system activities. So far, few studies have been reported on the beneficial immune modulatory effect of probiotics. However, many others, which are mainly focused on their metabolic/nutritional properties, have been published. Therefore, the mechanisms behind the interaction between host immune cells and probiotics have only been partially described. The present review aims to collect and summarize the most recent scientific results and the resulting implications of how probiotic bacteria and immune cells interact to improve immune functions. Hence, a description of the currently known immunomodulatory mechanisms of probiotic bacteria in improving the host immune system is provided.

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References

290

[1]

Intestinal Flora and Disease Mutually Shape the Regional Immune System in the Intestinal Tract

Bolun Zhou, Yutong Yuan, Shanshan Zhang et al.

Frontiers in Immunology 2020 10.3389/fimmu.2020.00575

[2]

Sharifi-Rad, J., Rodrigues, C.F., Stojanović-Radić, Z., Dimitrijević, M., Aleksić, A., Neffe-Skocińska, K., Zielińska, D., Kołożyn-Krajewska, D., Salehi, B., and Prabu, S.M. (2020). Probiotics: Versatile Bioactive Components in Promoting Human Health. Medicina, 56. 10.3390/medicina56090433

[3]

The microbiome and gut homeostasis

Jee-Yon Lee, Renée M. Tsolis, Andreas J. Bäumler

Science 2022 10.1126/science.abp9960

[4]

Chinda "Spatial distribution of live gut microbiota and bile acid metabolism in various parts of human large intestine" Sci. Rep. (2022) 10.1038/s41598-022-07594-6

[5]

Yan "Probiotics and immune health" Curr. Opin. Gastroenterol. (2011) 10.1097/mog.0b013e32834baa4d

[6]

Serek, P., and Oleksy-Wawrzyniak, M. (2021). The Effect of Bacterial Infections, Probiotics and Zonulin on Intestinal Barrier Integrity. Int. J. Mol. Sci., 22. 10.3390/ijms222111359

[7]

Morelli "FAO/WHO guidelines on probiotics: 10 years later" J. Clin. Gastroenterol. (2012) 10.1097/mcg.0b013e318269fdd5

[8]

Ashraf "Immune System Stimulation by Probiotic Microorganisms" Crit. Rev. Food Sci. Nutr. (2014) 10.1080/10408398.2011.619671

[9]

The International Scientific Association for Probiotics and Prebiotics consensus statement on the scope and appropriate use of the term probiotic

Colin Hill, Francisco Guarner, Gregor Reid et al.

Nature Reviews Gastroenterology & Hepatology 2014 10.1038/nrgastro.2014.66

[10]

Adel "Effect of Potential Probiotic Lactococcus lactis Subsp. lactis on Growth Performance, Intestinal Microbiota, Digestive Enzyme Activities, and Disease Resistance of Litopenaeus vannamei" Probiotics Antimicrob. Proteins (2017) 10.1007/s12602-016-9235-9

[11]

Sikes "The intestinal microbiota, gastrointestinal environment and colorectal cancer: A putative role for probiotics in prevention of colorectal cancer?" Am. J. Physiol. Gastrointest. Liver Physiol. (2011) 10.1152/ajpgi.00110.2011

[12]

Beneficial Effects of Probiotic Consumption on the Immune System

Carolina Maldonado Galdeano, Silvia Inés Cazorla, José María Lemme Dumit et al.

Annals of Nutrition and Metabolism 2019 10.1159/000496426

[13]

Chartrand "Is there a relationship between intestinal microbiota, dietary compounds, and obesity?" Trends Food Sci. Technol. (2017) 10.1016/j.tifs.2017.10.010

[14]

Umair "Probiotic-Based Bacteriocin: Immunity Supplementation Against Viruses. An Updated Review" Front. Microbiol. (2022) 10.3389/fmicb.2022.876058

[15]

Peng "Lacticaseibacillus rhamnosus alleviates intestinal inflammation and promotes microbiota-mediated protection against Salmonella fatal infections" Front. Immunol. (2022) 10.3389/fimmu.2022.973224

[16]

Sharma, A. (2019). Importance of Probiotics in Cancer Prevention and Treatment. Recent Dev. Appl. Microbiol. Biochem., 33–45. 10.1016/b978-0-12-816328-3.00004-0

[17]

Smith, D., Jheeta, S., Fuentes, H.V., and Palacios-Pérez, M. (2022). Feeding Our Microbiota: Stimulation of the Immune/Semiochemical System and the Potential Amelioration of Non-Communicable Diseases. Life, 12. 10.3390/life12081197

[18]

Anand "Screening of Phosphate-accumulating Probiotics for Potential Use in Chronic Kidney Disorder" Food Sci. Technol. Res. (2019) 10.3136/fstr.25.89

[19]

Cervin "The potential for topical probiotic treatment of chronic rhinosinusitis, a personal perspective" Front. Cell. Infect. Microbiol. (2018) 10.3389/fcimb.2017.00530

[20]

Kim "The Microbiota-Gut-Brain Axis in Neuropsychiatric Disorders: Pathophysiological Mechanisms and Novel Treatments" Curr. Neuropharmacol. (2018) 10.2174/1570159x15666170915141036

[21]

Pileggi "Probiotics and live biotherapeutic products aiming at cancer mitigation and patient recover" Front. Genet. (2022) 10.3389/fgene.2022.921972

[22]

Beterams "Versatile human in vitro triple coculture model coincubated with adhered gut microbes reproducibly mimics pro-inflammatory host-microbe interactions in the colon" FASEB J. (2021) 10.1096/fj.202101135r

[23]

Kumar "Recent advances in the concept of paraprobiotics: Nutraceutical/functional properties for promoting children health" Crit Rev Food Sci Nutr. (2021)

[24]

Ke "Current and Future Perspectives on the Role of Probiotics, Prebiotics, and Synbiotics in Controlling Pathogenic Cronobacter Spp. in Infants" Front. Microbiol. (2021) 10.3389/fmicb.2021.755083

[25]

Fidanza "Lactiplantibacillus plantarum–Nomad and Ideal Probiotic" Front. Microbiol. (2021) 10.3389/fmicb.2021.712236

[26]

Hunyady "Gastrointestinal immunology: Cell types in the lamina propria—A morphological review" Acta Physiol Hung (2000)

[27]

Donaldson "The Gut-Associated Lymphoid Tissues in the Small Intestine, Not the Large Intestine, Play a Major Role in Oral Prion Disease Pathogenesis" J. Virol. (2015) 10.1128/jvi.01544-15

[28]

Fenton "Human gut-associated lymphoid tissues (GALT); diversity, structure, and function" Mucosal Immunol. (2021) 10.1038/s41385-021-00389-4

[29]

Liu "Dendritic Cells" Encycl. Cell Biol. (2016) 10.1016/b978-0-12-394447-4.30111-0

[30]

Reinholdt, J., and Husby, S. (2013). IgA and Mucosal Homeostasis, Landes Bioscience.

[31]

Rotondo, J.C., Martini, F., Maritati, M., Caselli, E., Gallenga, C.E., Guarino, M., De Giorgio, R., Mazziotta, C., Tramarin, M.L., and Badiale, G. (2022). Advanced Molecular and Immunological Diagnostic Methods to Detect SARS-CoV-2 Infection. Microorganisms, 10. 10.3390/microorganisms10061193

[32]

Nogueira, D.S., De Oliveira, L.M., Amorim, C.C.O., Gazzinelli-Guimaraes, A.C., Barbosa, F.S., Oliveira, F.M.S., Kraemer, L., Mattos, M., Cardoso, M.S., and Resende, N.M. (2021). Eosinophils mediate SIgA production triggered by TLR2 and TLR4 to control Ascaris suum infection in mice. PLoS Pathog., 17. 10.1371/journal.ppat.1010067

[33]

Hansen "The inflammatory function of human IgA" Cell. Mol. Life Sci. (2018) 10.1007/s00018-018-2976-8

[34]

Hollenberg "The innate immune response, microenvironment proteinases, and the COVID-19 pandemic: Pathophysiologic mechanisms and emerging therapeutic targets" Kidney Int. Suppl. (2022) 10.1016/j.kisu.2021.12.001

[35]

Primorac "Adaptive Immune Responses and Immunity to SARS-CoV-2" Front. Immunol. (2022) 10.3389/fimmu.2022.848582

[36]

Malagutti, N., Rotondo, J.C., Cerritelli, L., Melchiorri, C., De Mattei, M., Selvatici, R., Oton-Gonzalez, L., Stomeo, F., Mazzoli, M., and Borin, M. (2020). High human papillomavirus DNA loads in inflammatory middle ear diseases. Pathogens, 9. 10.3390/pathogens9030224

[37]

Rigo "BID and the α-bisabolol-triggered cell death program: Converging on mitochondria and lysosomes" Cell Death Dis. (2019) 10.1038/s41419-019-2126-8

[38]

Mazziotta "Significantly low levels of IgG antibodies against oncogenic Merkel cell polyomavirus in sera from females affected by spontaneous abortion" Front. Microbiol. (2021) 10.3389/fmicb.2021.789991

[39]

Guihot "Cell-Mediated Immune Responses to COVID-19 Infection" Front. Immunol. (2020) 10.3389/fimmu.2020.01662

[40]

Rotondo, J.C., Mazziotta, C., Lanzillotti, C., Tognon, M., and Martini, F. (2021). Epigenetic Dysregulations in Merkel Cell Polyomavirus-Driven Merkel Cell Carcinoma. Int. J. Mol. Sci., 22. 10.3390/ijms222111464

[41]

Mazziotta "The role of histone post-translational modifications in Merkel cell carcinoma" Front. Oncol. (2022) 10.3389/fonc.2022.832047

[42]

Golubovskaya, V., and Wu, L. (2016). Different Subsets of T Cells, Memory, Effector Functions, and CAR-T Immunotherapy. Cancers, 8. 10.3390/cancers8030036

[43]

Luckheeram "CD4 +T cells: Differentiation and functions" Clin. Dev. Immunol. (2012) 10.1155/2012/925135

[44]

Kany, S., Vollrath, J.T., and Relja, B. (2019). Cytokines in Inflammatory Disease. Int. J. Mol. Sci., 20. 10.3390/ijms20236008

[45]

Corazza "Tissue cytokine/chemokine profile in vulvar lichen sclerosus: An observational study on keratinocyte and fibroblast cultures" J. Dermatol. Sci. (2020) 10.1016/j.jdermsci.2020.09.006

[46]

Ferrarini "Classical Hodgkin lymphoma cells may promote an IL-17-enriched microenvironment" Leuk. Lymphoma (2019) 10.1080/10428194.2019.1636983

[47]

Krawiec "Interleukin 10 and interleukin 10 receptor in paediatric inflammatory bowel disease: From bench to bedside lesson" J. Inflamm. (2021) 10.1186/s12950-021-00279-3

[48]

Cancer biology and molecular genetics of A3 adenosine receptor

Chiara Mazziotta, John Charles Rotondo, Carmen Lanzillotti et al.

Oncogene 2021 10.1038/s41388-021-02090-z

[49]

The Role of Purinergic P2X7 Receptor in Inflammation and Cancer: Novel Molecular Insights and Clinical Applications

John Charles Rotondo, Chiara Mazziotta, Carmen Lanzillotti et al.

Cancers 10.3390/cancers14051116

[50]

Weber "Probiotics and the Gut Immune System: Indirect Regulation" Probiotics Antimicrob. Proteins (2018) 10.1007/s12602-017-9322-6

Showing 50 of 290 references

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References

Details

Published: Jan 02, 2023
Vol/Issue: 12(1)
Pages: 184
License: View

Authors

C

Chiara Mazziotta

Department of Medical Sciences, University of Ferrara, 44121 Ferrara, Italy; Center for Studies on Gender Medicine, Department of Medical Sciences, University of Ferrara, 64/b, Fossato di Mortara Street, 44121 Ferrara, Italy

M

Mauro Tognon

Department of Medical Sciences, University of Ferrara, 44121 Ferrara, Italy

F

Fernanda Martini

Department of Medical Sciences, University of Ferrara, 44121 Ferrara, Italy; Center for Studies on Gender Medicine, Department of Medical Sciences, University of Ferrara, 64/b, Fossato di Mortara Street, 44121 Ferrara, Italy; Laboratory for Technologies of Advanced Therapies (LTTA), University of Ferrara, 44121 Ferrara, Italy

E

Elena Torreggiani

Department of Medical Sciences, University of Ferrara, 44121 Ferrara, Italy

J

John Charles Rotondo

Department of Medical Sciences, University of Ferrara, 44121 Ferrara, Italy; Center for Studies on Gender Medicine, Department of Medical Sciences, University of Ferrara, 64/b, Fossato di Mortara Street, 44121 Ferrara, Italy

Funding

University of Ferrara Award: 2021

Cite This Article

Chiara Mazziotta, Mauro Tognon, Fernanda Martini, et al. (2023). Probiotics Mechanism of Action on Immune Cells and Beneficial Effects on Human Health. Cells, 12(1), 184. https://doi.org/10.3390/cells12010184

Probiotics Mechanism of Action on Immune Cells and Beneficial Effects on Human Health

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