MHC Genomics and Disease: Looking Back to Go Forward

Roger L. Dawkins; Sally S. Lloyd

doi:10.3390/cells8090944

journal article Open Access Aug 21, 2019

MHC Genomics and Disease: Looking Back to Go Forward

Roger L. Dawkins Sally S. Lloyd

Cells Vol. 8 No. 9 pp. 944 · MDPI AG

View at Publisher Save 10.3390/cells8090944

Abstract

Ancestral haplotypes are conserved but extremely polymorphic kilobase sequences, which have been faithfully inherited over at least hundreds of generations in spite of migration and admixture. They carry susceptibility and resistance to diverse diseases, including deficiencies of CYP21 hydroxylase (47.1) and complement components (18.1), as well as numerous autoimmune diseases (8.1). The haplotypes are detected by segregation within ethnic groups rather than by SNPs and GWAS. Susceptibility to some other diseases is carried by specific alleles shared by multiple ancestral haplotypes, e.g., ankylosing spondylitis and narcolepsy. The difference between these two types of association may explain the disappointment with many GWAS. Here we propose a pathway for combining the two different approaches. SNP typing is most useful after the conserved ancestral haplotypes have been defined by other methods.

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Details

Published: Aug 21, 2019
Vol/Issue: 8(9)
Pages: 944
License: View

Authors

R

Roger L. Dawkins

Centre for Innovation in Agriculture, Murdoch University and C Y O’Connor ERADE Village Foundation, North Dandalup 6207, Western Australia, Australia

S

Sally S. Lloyd

Centre for Innovation in Agriculture, Murdoch University and C Y O’Connor ERADE Village Foundation, North Dandalup 6207, Western Australia, Australia

Cite This Article

Roger L. Dawkins, Sally S. Lloyd (2019). MHC Genomics and Disease: Looking Back to Go Forward. Cells, 8(9), 944. https://doi.org/10.3390/cells8090944

MHC Genomics and Disease: Looking Back to Go Forward

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