Stress Erythropoiesis is a Key Inflammatory Response

Robert F. Paulson; Baiye Ruan; Siyang Hao; Yuanting Chen

doi:10.3390/cells9030634

journal article Open Access Mar 06, 2020

Stress Erythropoiesis is a Key Inflammatory Response

Robert F. Paulson Baiye Ruan Siyang Hao Yuanting Chen

Cells Vol. 9 No. 3 pp. 634 · MDPI AG

View at Publisher Save 10.3390/cells9030634

Abstract

Bone marrow medullary erythropoiesis is primarily homeostatic. It produces new erythrocytes at a constant rate, which is balanced by the turnover of senescent erythrocytes by macrophages in the spleen. Despite the enormous capacity of the bone marrow to produce erythrocytes, there are times when it is unable to keep pace with erythroid demand. At these times stress erythropoiesis predominates. Stress erythropoiesis generates a large bolus of new erythrocytes to maintain homeostasis until steady state erythropoiesis can resume. In this review, we outline the mechanistic differences between stress erythropoiesis and steady state erythropoiesis and show that their responses to inflammation are complementary. We propose a new hypothesis that stress erythropoiesis is induced by inflammation and plays a key role in maintaining erythroid homeostasis during inflammatory responses.

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Metrics

92

Citations

116

References

Details

Published: Mar 06, 2020
Vol/Issue: 9(3)
Pages: 634
License: View

Authors

R

Robert F. Paulson

Department of Veterinary and Biomedical Sciences, Center for Molecular Immunology and Infectious Disease at Penn State University, University Park, PA 16802, USA

B

Baiye Ruan

Department of Veterinary and Biomedical Sciences, Pathobiology Graduate Program at Penn State University, University Park, PA 16802, USA

S

Siyang Hao

Department of Veterinary and Biomedical Sciences, Graduate Program in Molecular, Cellular and Integrative Biosciences at Penn State University, University Park, PA 16802, USA

Y

Yuanting Chen

Department of Veterinary and Biomedical Sciences, Graduate Program in Molecular, Cellular and Integrative Biosciences at Penn State University, University Park, PA 16802, USA

Funding

National Institutes of Health Award: RO1 DK080040

U.S. Department of Agriculture Award: Hatch Project PEN04605 Accession #1010021

Cite This Article

Robert F. Paulson, Baiye Ruan, Siyang Hao, et al. (2020). Stress Erythropoiesis is a Key Inflammatory Response. Cells, 9(3), 634. https://doi.org/10.3390/cells9030634

Stress Erythropoiesis is a Key Inflammatory Response

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