Therapeutic miRNA-Enriched Extracellular Vesicles: Current Approaches and Future Prospects

Javaria Munir; Jeong Kyo Yoon; Seongho Ryu

doi:10.3390/cells9102271

journal article Open Access Oct 11, 2020

Therapeutic miRNA-Enriched Extracellular Vesicles: Current Approaches and Future Prospects

Javaria Munir Jeong Kyo Yoon Seongho Ryu

Cells Vol. 9 No. 10 pp. 2271 · MDPI AG

View at Publisher Save 10.3390/cells9102271

Abstract

Extracellular vesicles (EVs) are 50–300 nm vesicles secreted by eukaryotic cells. They can carry cargo (including miRNA) from the donor cell to the recipient cell. miRNAs in EVs can change the translational profile of the recipient cell and modulate cellular morphology. This endogenous mechanism has attracted the attention of the drug-delivery community in the last few years. EVs can be enriched with exogenous therapeutic miRNAs and used for treatment of diseases by targeting pathological recipient cells. However, there are some obstacles that need to be addressed before introducing therapeutic miRNA-enriched EVs in clinics. Here, we focused on the progress in the field of therapeutic miRNA enriched EVs, highlighted important areas where research is needed, and discussed the potential to use them as therapeutic miRNA carriers in the future.

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Details

Published: Oct 11, 2020
Vol/Issue: 9(10)
Pages: 2271
License: View

Authors

J

Javaria Munir

Soonchunhyang Institute of Medibioscience (SIMS), Soonchunhyang University, Cheonan, Chungcheongnam-do 31151, Korea; Department of Integrated Biomedicine, Soonchunhyang University, Cheonan, Chungcheongnam-do 31151, Korea; Department of Biochemistry, Quaid-i-Azam University, Islamabad 45320, Pakistan

J

Jeong Kyo Yoon

Soonchunhyang Institute of Medibioscience (SIMS), Soonchunhyang University, Cheonan, Chungcheongnam-do 31151, Korea; Department of Integrated Biomedicine, Soonchunhyang University, Cheonan, Chungcheongnam-do 31151, Korea

S

Seongho Ryu

Soonchunhyang Institute of Medibioscience (SIMS), Soonchunhyang University, Cheonan, Chungcheongnam-do 31151, Korea; Department of Integrated Biomedicine, Soonchunhyang University, Cheonan, Chungcheongnam-do 31151, Korea

Funding

Bio & Medical Technology Development Program of the National Research Foundation (NRF) via grant number 2019M3E5D3073092. NRF is a program of Ministry of Science, ICT and Future Planning, South Korea. Award: 2019M3E5D3073092.

Cite This Article

Javaria Munir, Jeong Kyo Yoon, Seongho Ryu (2020). Therapeutic miRNA-Enriched Extracellular Vesicles: Current Approaches and Future Prospects. Cells, 9(10), 2271. https://doi.org/10.3390/cells9102271

Therapeutic miRNA-Enriched Extracellular Vesicles: Current Approaches and Future Prospects

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