Numerical Investigation of a Thermal Ablation Porous Media-Based Model for Tumoral Tissue with Variable Porosity

Assunta Andreozzi; Luca Brunese; Marcello Iasiello; Claudio Tucci; Giuseppe Peter Vanoli

doi:10.3390/computation9050050

journal article Open Access Apr 23, 2021

Numerical Investigation of a Thermal Ablation Porous Media-Based Model for Tumoral Tissue with Variable Porosity

Assunta Andreozzi

Luca Brunese Marcello Iasiello Claudio Tucci Giuseppe Peter Vanoli

Computation Vol. 9 No. 5 pp. 50 · MDPI AG

View at Publisher Save 10.3390/computation9050050

Abstract

Thermal ablation is a minimally or noninvasive cancer therapy technique that involves fewer complications, shorter hospital stays, and fewer costs. In this paper, a thermal-ablation bioheat model for cancer treatment is numerically investigated, using a porous media-based model. The main objective is to evaluate the effects of a variable blood volume fraction in the tumoral tissue (i.e., the porosity), in order to develop a more realistic model. A modified local thermal nonequilibrium model (LTNE) is implemented including the water content vaporization in the two phases separately and introducing the variable porosity in the domain, described by a quadratic function changing from the core to the rim of the tumoral sphere. The equations are numerically solved employing the finite-element commercial code COMSOL Multiphysics. Results are compared with the results obtained employing two uniform porosity values (ε = 0.07 and ε = 0.23) in terms of coagulation zones at the end of the heating period, maximum temperatures reached in the domain, and temperature fields and they are presented for different blood vessels. The outcomes highlight how important is to predict coagulation zones achieved in thermal ablation accurately. In this way, indeed, incomplete ablation, tumor recurrence, or healthy tissue necrosis can be avoided, and medical protocols and devices can be improved.

Topics

No keywords indexed for this article. Browse by subject →

References

33

[1]

Chu "Thermal ablation of tumours: Biological mechanisms and advances in therapy" Nat. Rev. Cancer (2014) 10.1038/nrc3672

[2]

Thermal Tumor Ablation in Clinical Use

Chris Brace

IEEE Pulse 2011 10.1109/mpul.2011.942603

[3]

Diederich "Thermal ablation and high-temperature thermal therapy: Overview of technology and clinical implementation" Int. J. Hyperth. (2005) 10.1080/02656730500271692

[4]

Nikfarjam "Mechanisms of Focal Heat Destruction of Liver Tumors" J. Surg. Res. (2005) 10.1016/j.jss.2005.02.009

[5]

Moros, E. (2012). Physics of Thermal Therapy: Fundamentals and Clinical Applications, CRC Press.

[6]

Analysis of Tissue and Arterial Blood Temperatures in the Resting Human Forearm

Harry H. Pennes

Journal of Applied Physiology 1948 10.1152/jappl.1948.1.2.93

[7]

Berjano "Theoretical modeling for radiofrequency ablation: State-of-the-art and challenges for the future" Biomed. Eng. Online (2006) 10.1186/1475-925x-5-24

[8]

Andreozzi "Modeling Heat Transfer in Tumors: A Review of Thermal Therapies" Ann. Biomed. Eng. (2018) 10.1007/s10439-018-02177-x

[9]

Almekkawy "Therapeutic Systems and Technologies: State-of-the-Art Applications, Opportunities, and Challenges" IEEE Rev. Biomed. Eng. (2019) 10.1109/rbme.2019.2908940

[10]

Andreozzi "Bioheat transfer in a spherical biological tissue: A comparison among various models" J. Phys. Conf. Ser. (2019) 10.1088/1742-6596/1224/1/012001

[11]

Lucia "Constructal law and ion transfer in normal and cancer cells" Proc. Rom. Acad. A Spec. Issue (2019)

[12]

Lucia "Constructal approach to cell membranes transport: Amending the ‘Norton-Simon’ hypothesis for cancer treatment" Sci. Rep. (2016) 10.1038/srep19451

[13]

Singh "Thermal ablation of biological tissues in disease treatment: A review of computational models and future directions" Electromagn. Biol. Med. (2020) 10.1080/15368378.2020.1741383

[14]

Vafai, K. (2015). Handbook of Porous Media, CRC Press. 10.1201/b18614

[15]

Xuan "Bioheat equation of the human thermal system" Chem. Eng. Technol. (1997) 10.1002/ceat.270200407

[16]

The role of porous media in modeling flow and heat transfer in biological tissues

A.-R.A. Khaled, K. Vafai

International Journal of Heat and Mass Transfer 2003 10.1016/s0017-9310(03)00301-6

[17]

The role of porous media in biomedical engineering as related to magnetic resonance imaging and drug delivery

K. Khanafer, K. Vafai

Heat and Mass Transfer 2006 10.1007/s00231-006-0142-6

[18]

Nakayama "A general bioheat transfer model based on the theory of porous media" Int. J. Heat Mass Transf. (2008) 10.1016/j.ijheatmasstransfer.2007.05.030

[19]

Keangin "Analysis of heat transport on local thermal non-equilibrium in porous liver during microwave ablation" Int. J. Heat Mass Transf. (2013) 10.1016/j.ijheatmasstransfer.2013.07.064

[20]

Numerical study of heat transfer and blood flow in two-layered porous liver tissue during microwave ablation process using single and double slot antenna

Phadungsak Rattanadecho, Pornthip Keangin

International Journal of Heat and Mass Transfer 2013 10.1016/j.ijheatmasstransfer.2012.10.043

[21]

Dombrovsky "A combined transient thermal model for laser hyperthermia of tumors with embedded gold nanoshells" Int. J. Heat Mass Transf. (2011) 10.1016/j.ijheatmasstransfer.2011.07.045

[22]

Indirect heating strategy for laser induced hyperthermia: An advanced thermal model

Leonid A. Dombrovsky, Victoria Timchenko, Michael Jackson

International Journal of Heat and Mass Transfer 2012 10.1016/j.ijheatmasstransfer.2012.04.029

[23]

Andreozzi "A novel local thermal non-equilibrium model for biological tissue applied to multiple-antennas configurations for thermal ablation" Numer. Heat Transf. Part A Appl. (2020)

[24]

Stewart "Correlation between hepatic tumor blood flow and glucose utilization in a rabbit liver tumor model" Radiology (2006) 10.1148/radiol.2393041382

[25]

Crezee "Temperature uniformity during hyperthermia: The impact of large vessels" Phys. Med. Biol. (1992) 10.1088/0031-9155/37/6/009

[26]

Yuan "Numerical analysis of temperature and thermal dose response of biological tissues to thermal non-equilibrium during hyperthermia therapy" Med Eng. Phys. (2008) 10.1016/j.medengphy.2007.03.006

[27]

Chang "Considerations for thermal injury analysis for RF ablation devices" Open Biomed. Eng. J. (2010)

[28]

Zhang "Numerical analysis of the relationship between the area of target tissue necrosis and the size of target tissue in liver tumours with pulsed radiofrequency ablation" Int. J. Hyperth. (2015) 10.3109/02656736.2015.1058429

[29]

Abraham "A thermal-ablation bioheat model including liquid-to-vapor phase change, pressure- and necrosis-dependent perfusion, and moisture-dependent properties" Int. J. Heat Mass Transf. (2007) 10.1016/j.ijheatmasstransfer.2006.11.045

[30]

Smith "Dielectric Properties of VX-2 Carcinoma Versus Normal Liver Tissue" IEEE Trans. Biomed. Eng. (1986) 10.1109/tbme.1986.325740

[31]

Woodard "The composition of body tissues" Br. J. Radiol. (1986) 10.1259/0007-1285-59-708-1209

[32]

Trujillo "Computer modelling of an impedance-controlled pulsing protocol for RF tumour ablation with a cooled electrode" Int. J. Hyperth. (2016) 10.1080/02656736.2016.1190868

[33]

Cooper "Ablation with an internally irrigated radiofrequency catheter: Learning how to avoid steam pops" Heart Rhythm. (2004) 10.1016/j.hrthm.2004.04.019

Cited By

12

Coupled electromagnetic–thermal modeling of ferromagnetic implants in porous tissue for hyperthermia

Pongsavat Savatdipap, Teerapot Wessapan · 2026

International Journal of Thermoflui...

Metrics

12

Citations

33

References

Details

Published: Apr 23, 2021
Vol/Issue: 9(5)
Pages: 50
License: View

Authors

A

Assunta Andreozzi

Department of Industrial Engineering, University of Naples-Federico II, Piazzale Tecchio, 80, 80125 Napoli, Italy

L

Luca Brunese

Department of Medicine and Health Sciences “Vincenzo Tiberio”, University of Molise, Via Francesco De Sanctis 1, 86100 Campobasso, Italy

M

Marcello Iasiello

Department of Industrial Engineering, University of Naples-Federico II, Piazzale Tecchio, 80, 80125 Napoli, Italy

C

Claudio Tucci

Department of Medicine and Health Sciences “Vincenzo Tiberio”, University of Molise, Via Francesco De Sanctis 1, 86100 Campobasso, Italy

G

Giuseppe Peter Vanoli

Department of Medicine and Health Sciences “Vincenzo Tiberio”, University of Molise, Via Francesco De Sanctis 1, 86100 Campobasso, Italy

Funding

Ministero dell'Istruzione dell'Università e della Ricerca Award: PRIN-2017F7KZWS

Cite This Article

Assunta Andreozzi, Luca Brunese, Marcello Iasiello, et al. (2021). Numerical Investigation of a Thermal Ablation Porous Media-Based Model for Tumoral Tissue with Variable Porosity. Computation, 9(5), 50. https://doi.org/10.3390/computation9050050

Numerical Investigation of a Thermal Ablation Porous Media-Based Model for Tumoral Tissue with Variable Porosity

You May Also Like