Indonesian Vegetables: Searching for Antioxidant and Antidiabetic Therapeutic Agents

Dinar Mutia Rani; Nur Hanafi; Sudarko; Dessy Rachmawati; Tri Agus Siswoyo; Fransiska Maria Christianty; Ika Puspita Dewi; Ari Satia Nugraha

doi:10.3390/ddc2010002

journal article Open Access Jan 20, 2023

Indonesian Vegetables: Searching for Antioxidant and Antidiabetic Therapeutic Agents

Dinar Mutia Rani

Nur Hanafi

Sudarko Dessy Rachmawati

Tri Agus Siswoyo

Fransiska Maria Christianty

Ika Puspita Dewi

Ari Satia Nugraha

Drugs and Drug Candidates Vol. 2 No. 1 pp. 14-36 · MDPI AG

View at Publisher Save 10.3390/ddc2010002

Abstract

Diabetes mellitus prevalence in Indonesia reached 19.5 million cases, which has affected the productive age population. The indigenous people of Indonesia are blessed with the second largest biodiversity in the world, including vegetables, which are also prepared as medicaments. Vegetables are well-known as natural antioxidants which evolved in metabolic disease prevention, including diabetes mellitus. One of the Government of Indonesia’s strategic plans in health is to develop new antidiabetic from nature. In this study, nineteen vegetable species were collected and evaluated for their antioxidant activity followed by computational-based bioprospecting. The study indicated Ipomoea aquatica, Paederia foetida, Plumbago zeylanica, Nauclea pallida, Sauropus androgynus, Wrightia pubescens, and Psophocarpus tetragonolobus to contain high antioxidant components. Computational experiments on chemical constituents previously reported from the same species showed potent compounds with high affinity against α-glucosidase (3a4a). 7-O-β-D-glucopyranosyl-dihydroquercetin-3-O-α-D-glucopyranoside 1, stigmasterol 7, and chitanone 12 are the most potent compounds from Ipomoea aquatica, Paederia foetida, and Plumbago zeylanica, respectively, which are superior to a standard drug, acarbose. The four vegetable species are feasible for conventional drug sources or developed as botanical dosage according to the Indonesian government’s strategic plan. Further studies are necessary to ensure adequate preclinical and clinical data to meet the requirement of safe and potent medicine. Nevertheless, Nauclea pallida and Psophocarpus tetragonolobus are valuable species with potent yet understudied antioxidant sources.

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Details

Published: Jan 20, 2023
Vol/Issue: 2(1)
Pages: 14-36
License: View

Authors

D

Dinar Mutia Rani

Drug Utilisation and Discovery Research Group, Faculty of Pharmacy, University of Jember, Jember 68121, Indonesia

N

Nur Hanafi

Departement of Chemistry, Faculty of Mathemathics and Natural Sciences, University of Jember, Jember 68121, Indonesia

S

Sudarko

Departement of Chemistry, Faculty of Mathemathics and Natural Sciences, University of Jember, Jember 68121, Indonesia

D

Dessy Rachmawati

Department of Biomedical Science, Faculty of Dentistry, University of Jember, Jember 68121, Indonesia; Center of Excellence for Agromedicine (CEAMED), University of Jember, Jember 68121, Indonesia

T

Tri Agus Siswoyo

Graduate Program of Biotechnology, the Center of Excellence on Crop Industrial Biotechnology (PUI-PT BioTIn), University of Jember, Jember 68121, Indonesia

F

Fransiska Maria Christianty

Drug Utilisation and Discovery Research Group, Faculty of Pharmacy, University of Jember, Jember 68121, Indonesia

I

Ika Puspita Dewi

Drug Utilisation and Discovery Research Group, Faculty of Pharmacy, University of Jember, Jember 68121, Indonesia

A

Ari Satia Nugraha

Drug Utilisation and Discovery Research Group, Faculty of Pharmacy, University of Jember, Jember 68121, Indonesia; Center of Excellence for Agromedicine (CEAMED), University of Jember, Jember 68121, Indonesia; Graduate Program of Biotechnology, the Center of Excellence on Crop Industrial Biotechnology (PUI-PT BioTIn), University of Jember, Jember 68121, Indonesia; School of Chemistry and Molecular Biosciences, Molecular Horizons, Illawarra Health and Medical Research Institute University of Wollongong, Wollongong, NSW 2522, Australia

Funding

RMP-IsDB Project Award: SP DIPA 023.17.2.6.677562/2022

Cite This Article

Dinar Mutia Rani, Nur Hanafi, Sudarko, et al. (2023). Indonesian Vegetables: Searching for Antioxidant and Antidiabetic Therapeutic Agents. Drugs and Drug Candidates, 2(1), 14-36. https://doi.org/10.3390/ddc2010002

Indonesian Vegetables: Searching for Antioxidant and Antidiabetic Therapeutic Agents

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