Cell Decision Making through the Lens of Bayesian Learning

Arnab Barua; Haralampos Hatzikirou

doi:10.3390/e25040609

journal article Open Access Apr 03, 2023

Cell Decision Making through the Lens of Bayesian Learning

Arnab Barua

Haralampos Hatzikirou

Entropy Vol. 25 No. 4 pp. 609 · MDPI AG

View at Publisher Save 10.3390/e25040609

Abstract

Cell decision making refers to the process by which cells gather information from their local microenvironment and regulate their internal states to create appropriate responses. Microenvironmental cell sensing plays a key role in this process. Our hypothesis is that cell decision-making regulation is dictated by Bayesian learning. In this article, we explore the implications of this hypothesis for internal state temporal evolution. By using a timescale separation between internal and external variables on the mesoscopic scale, we derive a hierarchical Fokker–Planck equation for cell-microenvironment dynamics. By combining this with the Bayesian learning hypothesis, we find that changes in microenvironmental entropy dominate the cell state probability distribution. Finally, we use these ideas to understand how cell sensing impacts cell decision making. Notably, our formalism allows us to understand cell state dynamics even without exact biochemical information about cell sensing processes by considering a few key parameters.

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References

Details

Published: Apr 03, 2023
Vol/Issue: 25(4)
Pages: 609
License: View

Authors

A

Arnab Barua

Departement de Biochimie, Université de Montréal, Montréal, QC H3T 1C5, Canada; Centre Robert-Cedergren en Bio-Informatique et Génomique, Université de Montréal, Montréal, QC H3C 3J7, Canada

H

Haralampos Hatzikirou

Center for Information Services and High Performance Computing, Technische Univesität Dresden, 01062 Dresden, Germany; Mathematics Department, Khalifa University, Abu Dhabi P.O. Box 127788, United Arab Emirates

Funding

Khalifa University Award: 96732

Bundes Ministerium für Bildung und Forschung Award: 96732

Cite This Article

Arnab Barua, Haralampos Hatzikirou (2023). Cell Decision Making through the Lens of Bayesian Learning. Entropy, 25(4), 609. https://doi.org/10.3390/e25040609

Cell Decision Making through the Lens of Bayesian Learning

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