Stimulation of Hair Growth Effect by Fermented Ginsenosides Using Levilactobacillus brevis THK-D437

Eun-Ji Yi; Trang Thi Minh Nguyen; Jeehaeng Jeong; Xiangji Jin; Qiwen Zheng; Se-Jig Park; Gyeong-Seon Yi; Su-Jin Yang; Tae-Hoo Yi

doi:10.3390/fermentation10110565

journal article Open Access Nov 05, 2024

Stimulation of Hair Growth Effect by Fermented Ginsenosides Using Levilactobacillus brevis THK-D437

Eun-Ji Yi

Trang Thi Minh Nguyen

Jeehaeng Jeong Xiangji Jin

Qiwen Zheng Se-Jig Park Gyeong-Seon Yi

Su-Jin Yang Tae-Hoo Yi

Fermentation Vol. 10 No. 11 pp. 565 · MDPI AG

View at Publisher Save 10.3390/fermentation10110565

Abstract

Hair growth is crucial for physiological functions and psychological well-being, leading to an increasing demand for research in this area. While low-molecular ginsenosides have been shown to promote hair growth in mice, studies on their effects are limited, and there is a lack of research examining the impact of ginsenoside fermentation products derived from lactic acid bacteria. This study investigated the hair-growth-promoting effect of fermented ginsenoside by fermentation of Levilactobacillus brevis THK-D437, which was isolated from the traditional Korean fermented food kimchi and features high β-glucosidase activity. In the cell-based MTT assay, the proliferation rate was increased by 25% in the fermented ginsenoside-treated group on human hair dermal papilla cells (HHDPCs). In the alopecia mouse model study (C57BL/6 mouse model), enhanced hair growth was observed in the fermented ginsenoside-treated mouse groups. Tissue histological analyses showed that the number of hair follicles and the thickness of the epidermis, respectively, were increased in the fermented ginsenoside-treated mouse groups. These results suggested that fermented ginsenoside has a promoting effect on hair growth and a retarding effect on the catagen stage. Therefore, fermented ginseng products might be a new potential therapeutic candidate for promoting hair growth.

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Details

Published: Nov 05, 2024
Vol/Issue: 10(11)
Pages: 565
License: View

Authors

E

Eun-Ji Yi

Graduate School of Biotechnology, Kyung Hee University, 1732 Deogyeong-daero, Giheung, Yongin 17104, Republic of Korea; Snowwhitefactory Co., Ltd., 184, Jungbu-daero, Giheung, Yongin 17905, Republic of Korea

T

Trang Thi Minh Nguyen

Graduate School of Biotechnology, Kyung Hee University, 1732 Deogyeong-daero, Giheung, Yongin 17104, Republic of Korea

J

Jeehaeng Jeong

Snowwhitefactory Co., Ltd., 184, Jungbu-daero, Giheung, Yongin 17905, Republic of Korea

X

Xiangji Jin

Department of Dermatology, Graduate School, Kyung Hee University, 26 Kyungheedae-ro, Dong-daemun, Seoul 02447, Republic of Korea

Q

Qiwen Zheng

Graduate School of Biotechnology, Kyung Hee University, 1732 Deogyeong-daero, Giheung, Yongin 17104, Republic of Korea

S

Se-Jig Park

Graduate School of Biotechnology, Kyung Hee University, 1732 Deogyeong-daero, Giheung, Yongin 17104, Republic of Korea

G

Gyeong-Seon Yi

Department of Biopharmaceutical Biotechnology, Graduate School, Kyung Hee University, 1732 Deogyeong-daero, Giheung, Yongin 17104, Republic of Korea

S

Su-Jin Yang

Graduate School of Biotechnology, Kyung Hee University, 1732 Deogyeong-daero, Giheung, Yongin 17104, Republic of Korea

T

Tae-Hoo Yi

Graduate School of Biotechnology, Kyung Hee University, 1732 Deogyeong-daero, Giheung, Yongin 17104, Republic of Korea

Cite This Article

Eun-Ji Yi, Trang Thi Minh Nguyen, Jeehaeng Jeong, et al. (2024). Stimulation of Hair Growth Effect by Fermented Ginsenosides Using Levilactobacillus brevis THK-D437. Fermentation, 10(11), 565. https://doi.org/10.3390/fermentation10110565

Stimulation of Hair Growth Effect by Fermented Ginsenosides Using Levilactobacillus brevis THK-D437

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