Differential Interactions of Molecular Chaperones and Yeast Prions

Yury A. Barbitoff; Andrew G. Matveenko; Galina A. Zhouravleva

doi:10.3390/jof8020122

journal article Open Access Jan 27, 2022

Differential Interactions of Molecular Chaperones and Yeast Prions

Yury A. Barbitoff Andrew G. Matveenko

Galina A. Zhouravleva

Journal of Fungi Vol. 8 No. 2 pp. 122 · MDPI AG

View at Publisher Save 10.3390/jof8020122

Abstract

Baker’s yeast Saccharomyces cerevisiae is an important model organism that is applied to study various aspects of eukaryotic cell biology. Prions in yeast are self-perpetuating heritable protein aggregates that can be leveraged to study the interaction between the protein quality control (PQC) machinery and misfolded proteins. More than ten prions have been identified in yeast, of which the most studied ones include [PSI+], [URE3], and [PIN+]. While all of the major molecular chaperones have been implicated in propagation of yeast prions, many of these chaperones differentially impact propagation of different prions and/or prion variants. In this review, we summarize the current understanding of the life cycle of yeast prions and systematically review the effects of different chaperone proteins on their propagation. Our analysis clearly shows that Hsp40 proteins play a central role in prion propagation by determining the fate of prion seeds and other amyloids. Moreover, direct prion-chaperone interaction seems to be critically important for proper recruitment of all PQC components to the aggregate. Recent results also suggest that the cell asymmetry apparatus, cytoskeleton, and cell signaling all contribute to the complex network of prion interaction with the yeast cell.

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Details

Published: Jan 27, 2022
Vol/Issue: 8(2)
Pages: 122
License: View

Authors

Y

Yury A. Barbitoff

Department of Genetics and Biotechnology, St. Petersburg State University, 199034 St. Petersburg, Russia

A

Andrew G. Matveenko

Department of Genetics and Biotechnology, St. Petersburg State University, 199034 St. Petersburg, Russia

G

Galina A. Zhouravleva

Department of Genetics and Biotechnology, St. Petersburg State University, 199034 St. Petersburg, Russia; Laboratory of Amyloid Biology, St. Petersburg State University, 199034 St. Petersburg, Russia

Funding

Russian Science Foundation Award: 18-14-00050

Russian Foundation for Basic Research Award: 19-04-00173

Cite This Article

Yury A. Barbitoff, Andrew G. Matveenko, Galina A. Zhouravleva (2022). Differential Interactions of Molecular Chaperones and Yeast Prions. Journal of Fungi, 8(2), 122. https://doi.org/10.3390/jof8020122

Differential Interactions of Molecular Chaperones and Yeast Prions

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