New Approaches Based on Inflammatory Indexes in the Evaluation of the Neoplastic Potential of Colon Polyps

Sedat Ciftel; Serpil Ciftel; Aleksandra Klisic; Filiz Mercantepe

doi:10.3390/life14101259

journal article Open Access Oct 02, 2024

New Approaches Based on Inflammatory Indexes in the Evaluation of the Neoplastic Potential of Colon Polyps

Sedat Ciftel Serpil Ciftel Aleksandra Klisic

Filiz Mercantepe

Life Vol. 14 No. 10 pp. 1259 · MDPI AG

View at Publisher Save 10.3390/life14101259

Abstract

Colorectal polyps, precursors to colorectal cancer (CRC), require precise identification for appropriate diagnosis and therapy. This study aims to investigate the differences in hematological and inflammatory markers, specifically the CALLY index, HALP score, and immuno-inflammatory indexes, between neoplastic and nonneoplastic polyps. A retrospective cross-sectional study was conducted on 758 patients aged 61.0 ± 11.8 who underwent polypectomy between June 2021 and May 2024. Patients with colorectal adenocarcinoma (n = 22) were excluded. The polyps were classified into neoplastic and nonneoplastic categories based on histopathological evaluation. The study compared the CALLY index, HALP score, and various inflammatory indexes between neoplastic and nonneoplastic polyps. Out of 758 polyps analyzed, 514 were neoplastic, and 244 were nonneoplastic. Neoplastic polyps exhibited significantly lower CALLY and HALP scores (p < 0.05) and higher immuno-inflammatory indexes (p < 0.05) compared to nonneoplastic polyps. Dysplasia status, polyp diameter, and sigmoid colon localization were significant factors in determining neoplastic growth potential. No significant differences were observed in polyp localization in the proximal and distal colon segments or in solitary versus multiple polyps. The CALLY and HALP scores and immuno-inflammatory indexes can serve as valuable markers for distinguishing neoplastic from nonneoplastic polyps. These indexes reflect underlying inflammatory and immune responses, highlighting their potential utility in the early detection and risk stratification of colorectal polyps. Integrating these markers into clinical practice may enhance diagnostic accuracy and improve patient management, leading to timely interventions and better outcomes for individuals at risk of CRC.

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Details

Published: Oct 02, 2024
Vol/Issue: 14(10)
Pages: 1259
License: View

Authors

S

Sedat Ciftel

Department of Gastroenterology and Hepatology, Erzurum Training and Research Hospital, 25100 Erzurum, Turkey

S

Serpil Ciftel

Department of Endocrinology and Metabolism, Erzurum Training and Research Hospital, 25100 Erzurum, Turkey

A

Aleksandra Klisic

Faculty of Medicine, University of Montenegro, 81101 Podgorica, Montenegro; Center for Laboratory Diagnostics, Primary Health Care Center, 81000 Podgorica, Montenegro

F

Filiz Mercantepe

Department of Endocrinology and Metabolism, Faculty of Medicine, Recep Tayyip Erdogan University, 53010 Rize, Turkey

Funding

Recep Tayyip Erdoğan University Development Foundation

Cite This Article

Sedat Ciftel, Serpil Ciftel, Aleksandra Klisic, et al. (2024). New Approaches Based on Inflammatory Indexes in the Evaluation of the Neoplastic Potential of Colon Polyps. Life, 14(10), 1259. https://doi.org/10.3390/life14101259

New Approaches Based on Inflammatory Indexes in the Evaluation of the Neoplastic Potential of Colon Polyps

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