Antihypertensive and Angiotensin-I-Converting Enzyme (ACE)-Inhibitory Peptides from Fish as Potential Cardioprotective Compounds

Soheila Abachi; Laurent Bazinet; Lucie Beaulieu

doi:10.3390/md17110613

journal article Open Access Oct 29, 2019

Antihypertensive and Angiotensin-I-Converting Enzyme (ACE)-Inhibitory Peptides from Fish as Potential Cardioprotective Compounds

Soheila Abachi

Laurent Bazinet

Lucie Beaulieu

Marine Drugs Vol. 17 No. 11 pp. 613 · MDPI AG

View at Publisher Save 10.3390/md17110613

Abstract

The term metabolic/cardiometabolic/insulin resistance syndrome could generally be defined as the co-occurrence of several risk factors inclusive of systemic arterial hypertension. Not only that organizations, such as the world health organization (WHO) have identified high blood pressure as one of the main risk factors of the cardiometabolic syndrome, but there is also a link between the occurrence of insulin resistance/impaired glucose tolerance and hypertension that would consequently lead to type-2 diabetes (T2D). Hypertension is medicated by various classes of synthetic drugs; however, severe or mild adverse effects have been repeatedly reported. To avoid and reduce these adverse effects, natural alternatives, such as bioactive peptides derived from different sources have drawn the attention of researchers. Among all types of biologically active peptides inclusive of marine-derived ones, this paper’s focus would solely be on fish and fishery by-processes’ extracted peptides and products. Isolation and fractionation processes of these products alongside their structural, compositional and digestion stability characteristics have likewise been briefly discussed to better address the structure-activity relationship, expanding the reader’s knowledge on research and discovery trend of fish antihypertensive biopeptides. Furthermore, drug-likeness of selected biopeptides was predicted by Lipinski’s rules to differentiate a drug-like biopeptide from nondrug-like one.

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References

99

[1]

Diagnosis and Management of the Metabolic Syndrome

Scott M. Grundy, James I. Cleeman, Stephen R. Daniels et al.

Circulation 2005 10.1161/circulationaha.105.169404

[2]

Isomaa "Cardiovascular morbidity and mortality associated with the metabolic syndrome" Diabetes Care (2001) 10.2337/diacare.24.4.683

[3]

Gomes "Impact of diabetes on cardiovascular disease: An update" Int. J. Hypertens. (2013)

[4]

Kelli "Cardio metabolic syndrome: A global epidemic" J. Diabetes Metab. (2015)

[5]

Deitel "Overweight and obesity worldwide now estimated to involve 1.7 billion people" Obes. Surg. (2003) 10.1381/096089203765887598

[6]

Shulman "Ectopic fat in insulin resistance, dyslipidemia, and cardiometabolic disease" N. Engl. J. Med. (2014) 10.1056/nejmra1011035

[7]

Scholze, J., Alegria, E., Ferri, C., Langham, S., Stevens, W., Jeffries, D., and Uhl-Hochgraeber, K. (2010). Epidemiological and economic burden of metabolic syndrome and its consequences in patients with hypertension in Germany, Spain and Italy; a prevalence-based model. BMC Public Health, 10. 10.1186/1471-2458-10-529

[8]

Lind "Prevalence of insulin resistance in essential hypertension" J. Hypertens. (1995) 10.1097/00004872-199512000-00012

[9]

Castro "Cardiometabolic syndrome: Pathophysiology and treatment" Curr. Hypertens. Rep. (2003) 10.1007/s11906-003-0085-y

[10]

Murray "Global mortality, disability, and the contribution of risk factors: Global Burden of Disease Study" Lancet (1997) 10.1016/s0140-6736(96)07495-8

[11]

Giles "Expanding the definition and classification of hypertension" J. Clin. Hypertens. (2005) 10.1111/j.1524-6175.2005.04769.x

[12]

Angeli "Hypertension, inflammation and atrial fibrillation" J. Hypertens. (2014) 10.1097/hjh.0000000000000112

[13]

Bautista "Inflammation, endothelial dysfunction, and the risk of high blood pressure: Epidemiologic and biological evidence" J. Hum. Hypertens. (2003) 10.1038/sj.jhh.1001537

[14]

Chockalingam "Worldwide epidemic of hypertension" Can. J. Cardiol. (2006) 10.1016/s0828-282x(06)70275-6

[15]

Harrison "Inflammation, immunity, and hypertension" Hypertension (2011) 10.1161/hypertensionaha.110.163576

[16]

Berry "Catabolism in chronic heart failure" Eur. Heart J. (2000) 10.1053/euhj.1999.1882

[17]

Bhatt "Recent advances in vascular inflammation: C-reactive protein and other inflammatory biomarkers" Curr. Opin. Rheumatol. (2004) 10.1097/00002281-200401000-00005

[18]

Cardin "Evolution of the atrial fibrillation substrate in experimental congestive heart failure: Angiotensin-dependent and-independent pathways" Cardiovasc. Res. (2003) 10.1016/j.cardiores.2003.08.014

[19]

Nguyen "Hypertension management: An update" Am. Health Drug Benefits (2010)

[20]

The Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure<SUBTITLE>The JNC 7 Report</SUBTITLE>

Aram V. Chobanian

JAMA 2003 10.1001/jama.289.19.2560

[21]

Rudemiller "Inflammation and hypertension: New understandings and potential therapeutic targets" Curr. Hypertens. Rep. (2015) 10.1007/s11906-014-0507-z

[22]

Drapala "Statins, the renin–angiotensin–aldosterone system and hypertension–a tale of another beneficial effect of statins" J. Renin Angiotensin Aldosterone Syst. (2014) 10.1177/1470320314531058

[23]

Lee "Antihypertensive peptides from animal products, marine organisms, and plants" Food Chem. (2017) 10.1016/j.foodchem.2017.02.039

[24]

Daskaya-Dikmen, C., Yucetepe, A., Karbancioglu-Guler, F., Daskaya, H., and Ozcelik, B. (2017). Angiotensin-I-converting enzyme (ACE)-inhibitory peptides from plants. Nutrients, 9. 10.3390/nu9040316

[25]

Norris, R., and FitzGerald, R.J. (2013). Antihypertensive peptides from food proteins. Bioactive Food Peptides in Health and Disease, InTech Publishers. 10.5772/51710

[26]

Aluko "Antihypertensive peptides from food proteins" Annu. Rev. Food Sci. Technol. (2015) 10.1146/annurev-food-022814-015520

[27]

Miralles "Antihypertensive peptides from food proteins: A review" Food Funct. (2012) 10.1039/c2fo10192k

[28]

Premkumar "A critical review on food protein derived antihypertensive peptides" Drug Invent. Today (2019)

[29]

Recio "Antihypertensive peptides: Production, bioavailability and incorporation into foods" Adv. Colloid Interface Sci. (2011) 10.1016/j.cis.2010.11.001

[30]

Ono "Inhibition properties of dipeptides from salmon muscle hydrolysate on angiotensin I-converting enzyme" Int. J. Food Sci. Technol. (2006) 10.1111/j.1365-2621.2005.01080.x

[31]

Ono "Isolation of Peptides with Angiotensin I-converting Enzyme Inhibitory Effect Derived from Hydrolysate of Upstream Chum Salmon Muscle" J. Food Sci. (2003) 10.1111/j.1365-2621.2003.tb12300.x

[32]

Fang, L., Geng, M., Liu, C., Wang, J., Min, W., and Liu, J. (2019). Structural and molecular basis of angiotensin-converting enzyme by computational modeling: Insights into the mechanisms of different inhibitors. PLoS ONE, 14. 10.1371/journal.pone.0215609

[33]

Liu "Purification and characterization of angiotensin I converting enzyme inhibitory peptides from jellyfish Rhopilema esculentum" Food Res. Int. (2013) 10.1016/j.foodres.2012.11.002

[34]

Wijesekara "Angiotensin-I-converting enzyme (ACE) inhibitors from marine resources: Prospects in the pharmaceutical industry" Mar. Drugs (2010) 10.3390/md8041080

[35]

Kumar "Pharmacological review on natural ACE inhibitors" Der. Pharm. Lett. (2010)

[36]

Iwaniak "Food-originating ACE inhibitors, including antihypertensive peptides, as preventive food components in blood pressure reduction" Compr. Rev. Food Sci. Food Saf. (2014) 10.1111/1541-4337.12051

[37]

Attique, S.A., Hassan, M., Usman, M., Atif, R.M., Mahboob, S., Al-Ghanim, K.A., Bilal, M., and Nawaz, M.Z. (2019). A Molecular Docking Approach to Evaluate the Pharmacological Properties of Natural and Synthetic Treatment Candidates for Use against Hypertension. Int. J. Environ. Res. Public Health, 16. 10.3390/ijerph16060923

[38]

Bhuyan "Synthesis, characterization and antioxidant activity of angiotensin converting enzyme inhibitors" Org. Biomol. Chem. (2011) 10.1039/c0ob00823k

[39]

Ngo "Angiotensin-I converting enzyme inhibitory peptides from antihypertensive skate (Okamejei kenojei) skin gelatin hydrolysate in spontaneously hypertensive rats" Food Chem. (2015) 10.1016/j.foodchem.2014.11.013

[40]

Izzo "Angiotensin-converting enzyme inhibitors" J. Clin. Hypertens. (2011) 10.1111/j.1751-7176.2011.00508.x

[41]

Elliott "Incident diabetes in clinical trials of antihypertensive drugs: A network meta-analysis" Lancet (2007) 10.1016/s0140-6736(07)60108-1

[42]

Chen "Grass carp peptides hydrolysed by the combination of Alcalase and Neutrase: Angiotensin-I converting enzyme (ACE) inhibitory activity, antioxidant activities and physicochemical profiles" Int. J. Food Sci. Technol. (2016) 10.1111/ijfs.13002

[43]

Wang "Angiotensin I Converting Enzyme (ACE) inhibitory activity and antihypertensive effects of grass carp peptides" Food Sci. Biotechnol. (2014) 10.1007/s10068-014-0226-x

[44]

Ahn "Angiotensin I converting enzyme (ACE) inhibitory peptides from salmon byproduct protein hydrolysate by Alcalase hydrolysis" Process. Biochem. (2012) 10.1016/j.procbio.2012.08.019

[45]

Chen "Purification and characterization of a novel angiotensin-I converting enzyme (ACE) inhibitory peptide derived from enzymatic hydrolysate of grass carp protein" Peptides (2012) 10.1016/j.peptides.2011.11.006

[46]

Zhang "Macroporous resin purification of grass carp fish (Ctenopharyngodon idella) scale peptides with in vitro angiotensin-I converting enzyme (ACE) inhibitory ability" Food Chem. (2009) 10.1016/j.foodchem.2009.04.015

[47]

Borawska "Ex vivo digestion of carp muscle tissue–ACE inhibitory and antioxidant activities of the obtained hydrolysates" Food Funct. (2015) 10.1039/c4fo00621f

[48]

Nakajima "Comparison of ACE inhibitory and DPPH radical scavenging activities of fish muscle hydrolysates" Food Chem. (2009) 10.1016/j.foodchem.2008.10.083

[49]

Itou "Antihypertensive effect of narezushi, a fermented mackerel product, on spontaneously hypertensive rats" Fish. Sci. (2007) 10.1111/j.1444-2906.2007.01477.x

[50]

Neves "Bioactive peptides from Atlantic salmon (Salmo salar) with angiotensin converting enzyme and dipeptidyl peptidase IV inhibitory, and antioxidant activities" Food Chem. (2017) 10.1016/j.foodchem.2016.09.053

Showing 50 of 99 references

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Details

Published: Oct 29, 2019
Vol/Issue: 17(11)
Pages: 613
License: View

Authors

S

Soheila Abachi

Institute of Nutrition and Functional Foods (INAF), Université Laval, Quebec, QC G1V 0A6, Canada; Department of Food Science, Faculty of Agricultural and Food Sciences, Université Laval, Quebec, QC G1V 0A6, Canada

L

Laurent Bazinet

Institute of Nutrition and Functional Foods (INAF), Université Laval, Quebec, QC G1V 0A6, Canada; Department of Food Science, Faculty of Agricultural and Food Sciences, Université Laval, Quebec, QC G1V 0A6, Canada

L

Lucie Beaulieu

Institute of Nutrition and Functional Foods (INAF), Université Laval, Quebec, QC G1V 0A6, Canada; Department of Food Science, Faculty of Agricultural and Food Sciences, Université Laval, Quebec, QC G1V 0A6, Canada

Cite This Article

Soheila Abachi, Laurent Bazinet, Lucie Beaulieu (2019). Antihypertensive and Angiotensin-I-Converting Enzyme (ACE)-Inhibitory Peptides from Fish as Potential Cardioprotective Compounds. Marine Drugs, 17(11), 613. https://doi.org/10.3390/md17110613

Antihypertensive and Angiotensin-I-Converting Enzyme (ACE)-Inhibitory Peptides from Fish as Potential Cardioprotective Compounds

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