Effects of Astaxanthin from Shrimp Shell on Oxidative Stress and Behavior in Animal Model of Alzheimer’s Disease

Takunrat Taksima; Pennapa Chonpathompikunlert; Morakot Sroyraya; Pilaiwanwadee Hutamekalin; Maruj Limpawattana; Wanwimol Klaypradit

doi:10.3390/md17110628

journal article Open Access Nov 04, 2019

Effects of Astaxanthin from Shrimp Shell on Oxidative Stress and Behavior in Animal Model of Alzheimer’s Disease

Takunrat Taksima Pennapa Chonpathompikunlert Morakot Sroyraya Pilaiwanwadee Hutamekalin

Maruj Limpawattana

Wanwimol Klaypradit

Marine Drugs Vol. 17 No. 11 pp. 628 · MDPI AG

View at Publisher Save 10.3390/md17110628

Abstract

This study aimed to investigate the effect of astaxanthin (ASX) extracted and ASX powder from shrimp (Litopenaeus vannamei) shells on Wistar rats with Alzheimer’s disease, induced by amyloid-β (1-42) peptides. In this task, the rats were divided into eight groups: (1) Control, (2) sham operate, (3) negative control (vehicle) + Aβ1-42, (4) ASX extract+Aβ1-42, (5) commercial ASX + Aβ1-42, (6) ASX powder + Aβ1-42, (7) blank powder + Aβ1-42, and (8) vitamin E + Aβ1-42. All treatments were orally administrated for 30 days. At 14- and 29-days post injection, animals were observed in behavioral tests. On the 31st day, animals were sacrificed; the hippocampus and cortex were collected. Those two brain areas were then homogenized and stored for biochemical and histological analysis. The results showed that the Aβ1-42 infused group significantly reduced cognitive ability and increased memory loss, as assessed by the Morris water maze test, novel object recognition test, and novel object location test. Moreover, the Aβ1-42 infused group exhibited a deterioration of oxidative markers, including glutathione peroxidase enzymes (GPx), lipid peroxidation (MDA), products of protein oxidation, and superoxide anion in the cortex and the hippocampus. Meanwhile, ASX powder (10 mg/kg body weight) showed a significant reduction in cognitive and memory impairments and oxidative stress which is greater than ASX extract in the same dose of compound or vitamin E (100 mg/kg body weight). Our study indicates the beneficial properties of ASX in alleviation of cognitive functions and reducing neurodegeneration in Wistar rats induced by amyloid-β (1-42) peptides.

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Details

Published: Nov 04, 2019
Vol/Issue: 17(11)
Pages: 628
License: View

Authors

T

Takunrat Taksima

Department of Fishery Products, Faculty of Fisheries, Kasetsart University, Bangkok 10900, Thailand; Center for Advanced Studies for Agriculture and Food (CASAF), Kasetsart University Institute for Advanced Studies, Kasetsart University, Bangkok 10900, Thailand

P

Pennapa Chonpathompikunlert

Expert Centre of Innovative Health Food (InnoFood) Thailand Institute of Scientific and Technological Research (TISTR) 35 Moo 3 Technopolis, Khlong 5, Khlong Luang, Pathum Thani 12120, Thailand

M

Morakot Sroyraya

Department of Anatomy, Faculty of Science, Mahidol University, Bangkok 10400, Thailand

P

Pilaiwanwadee Hutamekalin

Department of Physiology, Faculty of Science, Prince of Songkla University, Hat Yai, Songkhla 90112, Thailand

M

Maruj Limpawattana

Department of Food Technology, Faculty of Science, Siam University, Bangkok 10160, Thailand

W

Wanwimol Klaypradit

Department of Fishery Products, Faculty of Fisheries, Kasetsart University, Bangkok 10900, Thailand; Center for Advanced Studies for Agriculture and Food (CASAF), Kasetsart University Institute for Advanced Studies, Kasetsart University, Bangkok 10900, Thailand

Cite This Article

Takunrat Taksima, Pennapa Chonpathompikunlert, Morakot Sroyraya, et al. (2019). Effects of Astaxanthin from Shrimp Shell on Oxidative Stress and Behavior in Animal Model of Alzheimer’s Disease. Marine Drugs, 17(11), 628. https://doi.org/10.3390/md17110628

Effects of Astaxanthin from Shrimp Shell on Oxidative Stress and Behavior in Animal Model of Alzheimer’s Disease

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