Secondary Metabolites from Marine-Derived Fungi and Actinobacteria as Potential Sources of Novel Colorectal Cancer Drugs

Elin Julianti; Ikram Ammar Abrian; Marlia Singgih Wibowo; Muhammad Azhari; Nadya Tsurayya; Fauzia Izzati; Ario Betha Juanssilfero; Asep Bayu; Siti Irma Rahmawati; Masteria Yunovilsa Putra

doi:10.3390/md20010067

journal article Open Access Jan 12, 2022

Secondary Metabolites from Marine-Derived Fungi and Actinobacteria as Potential Sources of Novel Colorectal Cancer Drugs

Elin Julianti Ikram Ammar Abrian Marlia Singgih Wibowo Muhammad Azhari

Nadya Tsurayya

Fauzia Izzati

Ario Betha Juanssilfero Asep Bayu Siti Irma Rahmawati Masteria Yunovilsa Putra

Marine Drugs Vol. 20 No. 1 pp. 67 · MDPI AG

View at Publisher Save 10.3390/md20010067

Abstract

Colorectal cancer is one of the most common cancers diagnosed in the world. Chemotheraphy is one of the most common methods used for the pharmacological treatment of this cancer patients. Nevertheless, the adverse effect of chemotherapy is not optimized for improving the quality of life of people who are older, who are the most vulnerable subpopulation. This review presents recent updates regarding secondary metabolites derived from marine fungi and actinobacteria as novel alternatives for cytotoxic agents against colorectal cancer cell lines HCT116, HT29, HCT15, RKO, Caco-2, and SW480. The observed marine-derived fungi were from the species Aspergillus sp., Penicillium sp., Neosartorya sp., Dichotomomyces sp., Paradendryphiella sp., and Westerdykella sp. Additionally, Streptomyces sp. and Nocardiopsis sp. are actinobacteria discussed in this study. Seventy one compounds reviewed in this study were grouped on the basis of their chemical structures. Indole alkaloids and diketopiperazines made up most compounds with higher potencies when compared with other groups. The potency of indole alkaloids and diketopiperazines was most probably due to halogen-based functional groups and sulfide groups, respectively.

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Published: Jan 12, 2022
Vol/Issue: 20(1)
Pages: 67
License: View

Authors

E

Elin Julianti

School of Pharmacy, Bandung Institute of Technology, Jl. Ganesha No.10, Bandung 40132, Indonesia

I

Ikram Ammar Abrian

School of Pharmacy, Bandung Institute of Technology, Jl. Ganesha No.10, Bandung 40132, Indonesia

M

Marlia Singgih Wibowo

School of Pharmacy, Bandung Institute of Technology, Jl. Ganesha No.10, Bandung 40132, Indonesia

M

Muhammad Azhari

School of Pharmacy, Bandung Institute of Technology, Jl. Ganesha No.10, Bandung 40132, Indonesia

N

Nadya Tsurayya

School of Pharmacy, Bandung Institute of Technology, Jl. Ganesha No.10, Bandung 40132, Indonesia

F

Fauzia Izzati