Update on Coagulase-Negative Staphylococci—What the Clinician Should Know

Ricarda Michels; Katharina Last; Sören L. Becker; Cihan Papan

doi:10.3390/microorganisms9040830

journal article Open Access Apr 14, 2021

Update on Coagulase-Negative Staphylococci—What the Clinician Should Know

Ricarda Michels Katharina Last

Sören L. Becker

Cihan Papan

Microorganisms Vol. 9 No. 4 pp. 830 · MDPI AG

View at Publisher Save 10.3390/microorganisms9040830

Abstract

Coagulase-negative staphylococci (CoNS) are among the most frequently recovered bacteria in routine clinical care. Their incidence has steadily increased over the past decades in parallel to the advancement in medicine, especially in regard to the utilization of foreign body devices. Many new species have been described within the past years, while clinical information to most of those species is still sparse. In addition, interspecies differences that render some species more virulent than others have to be taken into account. The distinct populations in which CoNS infections play a prominent role are preterm neonates, patients with implanted medical devices, immunodeficient patients, and those with other relevant comorbidities. Due to the property of CoNS to colonize the human skin, contamination of blood cultures or other samples occurs frequently. Hence, the main diagnostic hurdle is to correctly identify the cases in which CoNS are causative agents rather than contaminants. However, neither phenotypic nor genetic tools have been able to provide a satisfying solution to this problem. Another dilemma of CoNS in clinical practice pertains to their extensive antimicrobial resistance profile, especially in healthcare settings. Therefore, true infections caused by CoNS most often necessitate the use of second-line antimicrobial drugs.

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Details

Published: Apr 14, 2021
Vol/Issue: 9(4)
Pages: 830
License: View

Authors

R

Ricarda Michels

Institute of Medical Microbiology and Hygiene, Saarland University, 66424 Homburg, Germany

K

Katharina Last

Institute of Medical Microbiology and Hygiene, Saarland University, 66424 Homburg, Germany

S

Sören L. Becker

Institute of Medical Microbiology and Hygiene, Saarland University, 66424 Homburg, Germany

C

Cihan Papan

Institute of Medical Microbiology and Hygiene, Saarland University, 66424 Homburg, Germany

Cite This Article

Ricarda Michels, Katharina Last, Sören L. Becker, et al. (2021). Update on Coagulase-Negative Staphylococci—What the Clinician Should Know. Microorganisms, 9(4), 830. https://doi.org/10.3390/microorganisms9040830

Update on Coagulase-Negative Staphylococci—What the Clinician Should Know

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