Pharmacological Update Properties of Aloe Vera and its Major Active Constituents

Marta Sánchez; Elena González-Burgos; Irene Iglesias; M. Pilar Gómez-Serranillos

doi:10.3390/molecules25061324

journal article Open Access Mar 13, 2020

Pharmacological Update Properties of Aloe Vera and its Major Active Constituents

Marta Sánchez Elena González-Burgos

Irene Iglesias M. Pilar Gómez-Serranillos

Molecules Vol. 25 No. 6 pp. 1324 · MDPI AG

View at Publisher Save 10.3390/molecules25061324

Abstract

Aloe vera has been traditionally used to treat skin injuries (burns, cuts, insect bites, and eczemas) and digestive problems because its anti-inflammatory, antimicrobial, and wound healing properties. Research on this medicinal plant has been aimed at validating traditional uses and deepening the mechanism of action, identifying the compounds responsible for these activities. The most investigated active compounds are aloe-emodin, aloin, aloesin, emodin, and acemannan. Likewise, new actions have been investigated for Aloe vera and its active compounds. This review provides an overview of current pharmacological studies (in vitro, in vivo, and clinical trials), written in English during the last six years (2014–2019). In particular, new pharmacological data research has shown that most studies refer to anti-cancer action, skin and digestive protective activity, and antimicrobial properties. Most recent works are in vitro and in vivo. Clinical trials have been conducted just with Aloe vera, but not with isolated compounds; therefore, it would be interesting to study the clinical effect of relevant metabolites in different human conditions and pathologies. The promising results of these studies in basic research encourage a greater number of clinical trials to test the clinical application of Aloe vera and its main compounds, particularly on bone protection, cancer, and diabetes.

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References

Details

Published: Mar 13, 2020
Vol/Issue: 25(6)
Pages: 1324
License: View

Authors

M

Marta Sánchez

Department of Pharmacology, Pharmacognosy and Botany, Faculty of Pharmacy, Universidad Complutense de Madrid (UCM), 28040 Madrid, Spain

E

Elena González-Burgos

Department of Pharmacology, Pharmacognosy and Botany, Faculty of Pharmacy, Universidad Complutense de Madrid (UCM), 28040 Madrid, Spain

I

Irene Iglesias

Department of Pharmacology, Pharmacognosy and Botany, Faculty of Pharmacy, Universidad Complutense de Madrid (UCM), 28040 Madrid, Spain

M

M. Pilar Gómez-Serranillos

Department of Pharmacology, Pharmacognosy and Botany, Faculty of Pharmacy, Universidad Complutense de Madrid (UCM), 28040 Madrid, Spain

Cite This Article

Marta Sánchez, Elena González-Burgos, Irene Iglesias, et al. (2020). Pharmacological Update Properties of Aloe Vera and its Major Active Constituents. Molecules, 25(6), 1324. https://doi.org/10.3390/molecules25061324

Pharmacological Update Properties of Aloe Vera and its Major Active Constituents

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