Developments in Treatment Methodologies Using Dendrimers for Infectious Diseases

Nina Filipczak; Satya Siva Kishan Yalamarty; Xiang Li; Farzana Parveen; Vladimir Torchilin

doi:10.3390/molecules26113304

journal article Open Access May 31, 2021

Developments in Treatment Methodologies Using Dendrimers for Infectious Diseases

Nina Filipczak

Satya Siva Kishan Yalamarty

Xiang Li

Farzana Parveen

Vladimir Torchilin

Molecules Vol. 26 No. 11 pp. 3304 · MDPI AG

View at Publisher Save 10.3390/molecules26113304

Abstract

Dendrimers comprise a specific group of macromolecules, which combine structural properties of both single molecules and long expanded polymers. The three-dimensional form of dendrimers and the extensive possibilities for use of additional substrates for their construction creates a multivalent potential and a wide possibility for medical, diagnostic and environmental purposes. Depending on their composition and structure, dendrimers have been of interest in many fields of science, ranging from chemistry, biotechnology to biochemical applications. These compounds have found wide application from the production of catalysts for their use as antibacterial, antifungal and antiviral agents. Of particular interest are peptide dendrimers as a medium for transport of therapeutic substances: synthetic vaccines against parasites, bacteria and viruses, contrast agents used in MRI, antibodies and genetic material. This review focuses on the description of the current classes of dendrimers, the methodology for their synthesis and briefly drawbacks of their properties and their use as potential therapies against infectious diseases.

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Details

Published: May 31, 2021
Vol/Issue: 26(11)
Pages: 3304
License: View

Authors

N

Nina Filipczak

Center for Pharmaceutical Biotechnology and Nanomedicine, Northeastern University, Boston, MA 02115, USA

S

Satya Siva Kishan Yalamarty

Center for Pharmaceutical Biotechnology and Nanomedicine, Northeastern University, Boston, MA 02115, USA

X

Xiang Li

Center for Pharmaceutical Biotechnology and Nanomedicine, Northeastern University, Boston, MA 02115, USA; State Key Laboratory of Innovative Drug and Efficient Energy-Saving Pharmaceutical Equipment, Jiangxi University of Chinese Medicine, Nanchang 330006, China

F

Farzana Parveen

Center for Pharmaceutical Biotechnology and Nanomedicine, Northeastern University, Boston, MA 02115, USA; The Department of Pharmaceutics, Faculty of Pharmacy, The Islamia University of Bahawalpur, Bahawalpur 63100, Pakistan

V

Vladimir Torchilin

Center for Pharmaceutical Biotechnology and Nanomedicine, Northeastern University, Boston, MA 02115, USA; Department of Oncology, Radiotherapy and Plastic Surgery, I.M. Sechenov First Moscow State Medical University (Sechenov University), 119991 Moscow, Russia

Cite This Article

Nina Filipczak, Satya Siva Kishan Yalamarty, Xiang Li, et al. (2021). Developments in Treatment Methodologies Using Dendrimers for Infectious Diseases. Molecules, 26(11), 3304. https://doi.org/10.3390/molecules26113304

Developments in Treatment Methodologies Using Dendrimers for Infectious Diseases

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