Creatine in Health and Disease

Richard B. Kreider; Jeffery R. Stout

doi:10.3390/nu13020447

journal article Open Access Jan 29, 2021

Creatine in Health and Disease

Richard B. Kreider

Jeffery R. Stout

Nutrients Vol. 13 No. 2 pp. 447 · MDPI AG

View at Publisher Save 10.3390/nu13020447

Abstract

Although creatine has been mostly studied as an ergogenic aid for exercise, training, and sport, several health and potential therapeutic benefits have been reported. This is because creatine plays a critical role in cellular metabolism, particularly during metabolically stressed states, and limitations in the ability to transport and/or store creatine can impair metabolism. Moreover, increasing availability of creatine in tissue may enhance cellular metabolism and thereby lessen the severity of injury and/or disease conditions, particularly when oxygen availability is compromised. This systematic review assesses the peer-reviewed scientific and medical evidence related to creatine’s role in promoting general health as we age and how creatine supplementation has been used as a nutritional strategy to help individuals recover from injury and/or manage chronic disease. Additionally, it provides reasonable conclusions about the role of creatine on health and disease based on current scientific evidence. Based on this analysis, it can be concluded that creatine supplementation has several health and therapeutic benefits throughout the lifespan.

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Metrics

177

Citations

334

References

Details

Published: Jan 29, 2021
Vol/Issue: 13(2)
Pages: 447
License: View

Authors

R

Richard B. Kreider

Human Clinical Research Facility, Exercise & Sport Nutrition Lab, Department of Health & Kinesiology, Texas A&M University, College Station, TX 77843, USA

J

Jeffery R. Stout

Physiology of Work and Exercise Response (POWER) Laboratory, Institute of Exercise Physiology and Rehabilitation Science, School of Kinesiology and Physical Therapy, University of Central Florida, 12494 University Blvd., Orlando, FL 32816, USA

Cite This Article

Richard B. Kreider, Jeffery R. Stout (2021). Creatine in Health and Disease. Nutrients, 13(2), 447. https://doi.org/10.3390/nu13020447

Creatine in Health and Disease

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