journal article Open Access Jul 20, 2022

The Role of Resveratrol in Eye Diseases—A Review of the Literature

Nutrients Vol. 14 No. 14 pp. 2974 · MDPI AG
View at Publisher Save 10.3390/nu14142974
Abstract
Resveratrol (3,5,4′-trans-trihydroxystilbene) is a polyphenolic phytoalexin belonging to the stilbene family. It is commonly found in grape skins and seeds, as well as other plant-based foods. Oxidative stress and inflammation play a key role in the initiation and progression of age-related eye disorders (glaucoma, cataracts, diabetic retinopathy, and macular degeneration) that lead to a progressive loss of vision and blindness. Even though the way resveratrol affects the human body and the course of many diseases is still the subject of ongoing scientific research, it has been shown that the broad spectrum of anti-inflammatory and neuroprotective properties of resveratrol has a beneficial effect on eye tissues. In our research, we decided to analyze the current scientific literature on resveratrol, its possible mechanisms of action, and its therapeutic application in order to assess its effectiveness in eye diseases.
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References
139
[1]
Shrikanta "Resveratrol content and antioxidant properties of underutilized fruits" J. Food Sci. Technol. (2015) 10.1007/s13197-013-0993-z
[2]
Abu-Amero, K.K., Kondkar, A.A., and Chalam, K.V. (2016). Resveratrol and Ophthalmic Diseases. Nutrients, 8. 10.3390/nu8040200
[3]
Hasan, M., and Bae, H. (2017). An overview of stress-induced resveratrol synthesis in grapes: Perspectives for resveratrol-enriched grape products. Molecules, 22. 10.3390/molecules22020294
[4]
Takaoka "Resveratrol, a new phenolic compound from Veratrum grandiflorum" Nippon Kagaku Kaishi (1939) 10.1246/nikkashi1921.60.1090
[5]
Richard "Epidemiologic characteristics of coronary disease in France" Nouv. Presse Med. (1981)
[6]
Weiskirchen "Resveratrol: How Much Wine Do You Have to Drink to Stay Healthy?" Adv. Nutr. (2016) 10.3945/an.115.011627
[7]
Fauconneau "Comparative study of radical scavenger and antioxidant properties of phenolic compounds from Vitis vinifera cell cultures using in vitro tests" Life Sci. (1997) 10.1016/s0024-3205(97)00883-7
[8]
Huang, F.C., Kuo, H.C., Huang, Y.H., Yu, H.R., Li, S.C., and Kuo, H.C. (2017). Anti-inflammatory effect of resveratrol in human coronary arterial endothelial cells via induction of autophagy: Implication for the treatment of Kawasaki disease. BMC Pharmacol. Toxicol., 18. 10.1186/s40360-016-0109-2
[9]
Galiniak "Health benefits of resveratrol administration" Acta Biochim. Pol. (2019)
[10]
Guerrero "Wine, resveratrol and health: A review" Nat. Prod. Commun. (2009)
[11]
Delmas, D., Cornebise, C., Courtaut, F., Xiao, J., and Aires, V. (2021). New Highlights of Resveratrol: A Review of Properties against Ocular Diseases. Int. J. Mol. Sci., 22. 10.3390/ijms22031295
[12]
(2022, June 15). Pancrat—Praca Własna, CC BY-SA 3.0. Available online: https://commons.wikimedia.org/w/index.php?curid=5578972.
[13]
Howitz "Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan" Nature (2003) 10.1038/nature01960
[14]
Sajish "A human tRNA synthetase is a potent PARP1-activating effector target for resveratrol" Nature (2015) 10.1038/nature14028
[15]
Calleri "Resveratrol and its metabolites bind to PPARs" ChemBioChem (2014) 10.1002/cbic.201300754
[16]
Davies "Discovery of leukotriene A4 hydrolase inhibitors using metabolomics biased fragment crystallography" J. Med. Chem. (2009) 10.1021/jm900259h
[17]
Bhat "Biological effects of resveratrol. Antioxid" Redox. Signal (2001) 10.1089/152308601317203567
[18]
Gowda "Dietary polyphenols to combat the metabolic diseases via altering gut microbiota" Trends Food Sci. Technol. (2019) 10.1016/j.tifs.2019.09.005
[19]
Bioavailability of resveratrol

Thomas Walle

Annals of the New York Academy of Sciences 2011 10.1111/j.1749-6632.2010.05842.x
[20]
Lancon "Human hepatic cell uptake of resveratrol: Involvement of both passive diffusion and carrier-mediated process" Biochem. Biophys. Res. Commun. (2004) 10.1016/j.bbrc.2004.02.164
[21]
Meng, T., Xiao, D., Muhammed, A., Deng, J., Chen, L., and He, J. (2021). Anti-Inflammatory Action and Mechanisms of Resveratrol. Molecules, 26. 10.3390/molecules26010229
[22]
Lançon, A., Frazzi, R., and Latruffe, N. (2016). Anti-Oxidant, Anti-Inflammatory and Anti-Angiogenic Properties of Resveratrol in Ocular Diseases. Molecules, 21. 10.3390/molecules21030304
[23]
Ohtsu "Advanced glycation end products and lipopolysaccharides stimulate interleukin-6 secretion via the RAGE/TLR4-NF-κB-ROS pathways and resveratrol attenuates these inflammatory responses in mouse macrophages" Exp. Ther. Med. (2017)
[24]
Pinheiro "Resveratrol decreases the expression of genes involved in inflammation through transcriptional regulation" Free Radic. Biol. Med. (2018) 10.1016/j.freeradbiomed.2018.10.432
[25]
Chen, C.Y., Kao, C.L., and Liu, C.M. (2018). The cancer prevention, anti-inflamatory and anti-oxidation of bioactive phytochemicals targeting the TLR4 signaling pathway. Int. J. Mol. Sci., 19. 10.3390/ijms19092729
[26]
Li "Resveratrol attenuates inflammation and reduces matrix-metalloprotease expression by inducing autophagy via suppressing the Wnt/b-catenin signalling pathway in IL-1b-induced osteoarthritis chondrocytes" RSC Adv. (2018) 10.1039/c8ra00993g
[27]
Ma "Anti-inflammatory effect of resveratrol through the suppression of NF-κB and JAK/STAT signalling pathways" Acta Biochim. Biophys. Sin. (2015) 10.1093/abbs/gmu135
[28]
Tili "Resveratrol decreases the levels of miR-155 by upregulating miR-663, a microRNA targeting JunB and JunD" Carcinogenesis (2010) 10.1093/carcin/bgq143
[29]
Ghiringhelli "Immunomodulation and anti-inflammatory roles of polyphenols as anticancer agents" Anticancer Agents Med. Chem. (2012) 10.2174/187152012802650048
[30]
Latruffe "Exploring new ways of regulation by resveratrol involving miRNAs, with emphasis on inflammation" Ann. N. Y. Acad. Sci. (2015) 10.1111/nyas.12819
[31]
Li "Resveratrol inhibits the proliferation of A549 cells by inhibiting the expression of COX-2" Oncotargets Ther. (2018) 10.2147/ott.s157613
[32]
Magrone, T., Magrone, M., Russo, M.A., and Jirillo, E. (2019). Recent Advances on the Anti-Inflammatory and Antioxidant Properties of Red Grape Polyphenols: In Vitro and In Vivo Studies. Antioxidants, 9. 10.20944/preprints201912.0030.v1
[33]
Chandrasekharan "COX-3, a cyclooxygenase-1 variant inhibited by acetaminophen and other analgesic/antipyretic drugs: Cloning, structure, and expression" Proc. Natl. Acad. Sci. USA (2002) 10.1073/pnas.162468699
[34]
Dinchuk "COX-3: In the wrong frame in mind" Immunol. Lett. (2003) 10.1016/s0165-2478(02)00268-7
[35]
Schmassmann "Effects of inhibition of prostaglandin endoperoxide synthase-2 in chronic gastrointestinal ulcer models in rats" Br. J. Pharmacol. (1998) 10.1038/sj.bjp.0701672
[36]
Vane "Mechanism of action of nonsteroidal anti-inflammatory drugs" Am. J. Med. (1998) 10.1016/s0002-9343(97)00203-9
[37]
Greenhough "The COX-2/PGE2 pathway: Key roles in the hallmarks of cancer and adaptation to the tumour microenvironment" Carcinogenesis (2009) 10.1093/carcin/bgp014
[38]
Jang "Cancer chemopreventive activity of resveratrol, a natural product derived from grapes" Science (1997) 10.1126/science.275.5297.218
[39]
Chen "New Insights into the Role of Nuclear Factor-κB in Cell Growth Regulation" Am. J. Pathol. (2001) 10.1016/s0002-9440(10)61708-7
[40]
NF-κB: a key role in inflammatory diseases

Paul P. Tak, Gary S. Firestein

Journal of Clinical Investigation 2001 10.1172/jci11830
[41]
Hoesel "The complexity of NF-κB signaling in inflammation and cancer" Mol. Cancer (2013) 10.1186/1476-4598-12-86
[42]
The Nuclear Factor NF- B Pathway in Inflammation

T. Lawrence

Cold Spring Harbor Perspectives in Biology 2009 10.1101/cshperspect.a001651
[43]
Wang "Plumbagin inhibits LPS-induced inflammation through the inactivation of the nuclear factor-kappa B and mitogen activated protein kinase signaling pathways in RAW 264.7 cells" Food Chem. Toxicol. (2014) 10.1016/j.fct.2013.11.027
[44]
Tsai "Suppression of nitric oxide synthase and the down- regulation of the activation of NF-kappa B in macrophages by resveratrol" Br. J. Pharmacol. (1999) 10.1038/sj.bjp.0702357
[45]
Brassinosteroid regulates stomatal development by GSK3-mediated inhibition of a MAPK pathway

Tae-Wuk Kim, Marta Michniewicz, Dominique C. Bergmann et al.

Nature 2012 10.1038/nature10794
[46]
Johnson "Mitogen-activated protein kinase pathways mediated by ERK, JNK, and p38 protein kinases" Science (2002) 10.1126/science.1072682
[47]
Chun "Signal transduction pathways regulating cyclooxygenase-2 expression: Potential molecular targets for chemoprevention" Biochem. Pharmacol. (2004) 10.1016/j.bcp.2004.05.031
[48]
Raingeaud "Pro-inflammatory cytokines and environmental stress cause p38 mitogen-activated protein kinase activation by dual phosphorylation on tyrosine and threonine" J. Biol. Chem. (1995) 10.1074/jbc.270.13.7420
[49]
Koul "Role of p38 MAP Kinase Signal Transduction in Solid Tumors" Genes Cancer (2013) 10.1177/1947601913507951
[50]
Villegas "Resveratrol, a polyphenol found in grapes, suppresses oxidative damage and stimulates apoptosis during early colonic inflammation in rats" Biochem. Pharmacol. (2004) 10.1016/j.bcp.2003.12.024

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Published
Jul 20, 2022
Vol/Issue
14(14)
Pages
2974
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Cite This Article
Anna Bryl, Mariusz Falkowski, Katarzyna Zorena, et al. (2022). The Role of Resveratrol in Eye Diseases—A Review of the Literature. Nutrients, 14(14), 2974. https://doi.org/10.3390/nu14142974
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