The Roles of Vitamin C in Skin Health

Juliet Pullar; Anitra Carr; Margreet Vissers

doi:10.3390/nu9080866

journal article Open Access Aug 12, 2017

The Roles of Vitamin C in Skin Health

Juliet Pullar Anitra Carr

Margreet Vissers

Nutrients Vol. 9 No. 8 pp. 866 · MDPI AG

View at Publisher Save 10.3390/nu9080866

Abstract

The primary function of the skin is to act as a barrier against insults from the environment, and its unique structure reflects this. The skin is composed of two layers: the epidermal outer layer is highly cellular and provides the barrier function, and the inner dermal layer ensures strength and elasticity and gives nutritional support to the epidermis. Normal skin contains high concentrations of vitamin C, which supports important and well-known functions, stimulating collagen synthesis and assisting in antioxidant protection against UV-induced photodamage. This knowledge is often used as a rationale for the addition of vitamin C to topical applications, but the efficacy of such treatment, as opposed to optimising dietary vitamin C intake, is poorly understood. This review discusses the potential roles for vitamin C in skin health and summarises the in vitro and in vivo research to date. We compare the efficacy of nutritional intake of vitamin C versus topical application, identify the areas where lack of evidence limits our understanding of the potential benefits of vitamin C on skin health, and suggest which skin properties are most likely to benefit from improved nutritional vitamin C intake.

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References

187

[1]

Weller, R.H., John, A., Savin, J., and Dahl, M. (2008). The Function and Structure of Skin, Wiley-Blackwell. [5th ed.].

[2]

Patton, K.T., and Thibodeau, G.A. (2012). Anthony’s Textbook of Anatomy & Physiology, Elsevier.

[3]

Wickett "Structure and function of the epidermal barrier" Am. J. Infect. Control (2006) 10.1016/j.ajic.2006.05.295

[4]

Marks "The stratum corneum barrier: The final frontier" J. Nutr. (2004) 10.1093/jn/134.8.2017s

[5]

The skin: an indispensable barrier

Ehrhardt Proksch, Johanna M. Brandner, Jens‐Michael Jensen

Experimental Dermatology 2008 10.1111/j.1600-0625.2008.00786.x

[6]

Kottner "Age-associated skin conditions and diseases: Current perspectives and future options" Gerontologist (2016) 10.1093/geront/gnw003

[7]

Park "Role of micronutrients in skin health and function" Biomol. Ther. (2015) 10.4062/biomolther.2015.003

[8]

Boelsma "Human skin condition and its associations with nutrient concentrations in serum and diet" Am. J. Clin. Nutr. (2003) 10.1093/ajcn/77.2.348

[9]

Brescoll "A review of vitamin B12 in dermatology" Am. J. Clin. Dermatol. (2015) 10.1007/s40257-014-0107-3

[10]

Fedeles "Nutrition and bullous skin diseases" Clin. Dermatol. (2010) 10.1016/j.clindermatol.2010.03.036

[11]

Packer, L., and Fuchs, J. (1997). A History of Scurvy and Vitamin C. Vitamin C in Health and Disease, Marcel Dekker, Inc.. [1st ed.].

[12]

Talarico "Do you remember scurvy?" Clin. Ther. (2014)

[13]

Alqanatish "Childhood scurvy: An unusual cause of refusal to walk in a child" Pediatr. Rheumatol. (2015) 10.1186/s12969-015-0020-1

[14]

Peterkofsky "Ascorbate requirement for hydroxylation and secretion of procollagen: Relationship to inhibition of collagen synthesis in scurvy" Am. J. Clin. Nutr. (1991) 10.1093/ajcn/54.6.1135s

[15]

Ellinger "Efficacy of vitamin supplementation in situations with wound healing disorders: Results from clinical intervention studies" Curr. Opin. Clin. Nutr. Metab. Care (2009) 10.1097/mco.0b013e328331a5b5

[16]

Ross "Wound healing and collagen formation: II. Fine structure in experimental scurvy" J. Cell Biol. (1962) 10.1083/jcb.12.3.533

[17]

Hodges "Experimental scurvy in man" Am. J. Clin. Nutr. (1969) 10.1093/ajcn/22.5.535

[18]

Hodges "Clinical manifestations of ascorbic acid deficiency in man" Am. J. Clin. Nutr. (1971) 10.1093/ajcn/24.4.432

[19]

Evans, J.R., and Lawrenson, J.G. (2017). Antioxidant vitamin and mineral supplements for slowing the progression of age-related macular degeneration. Cochrane Database Syst. Rev. 10.1002/14651858.cd000254.pub4

[20]

Placzek "Ultraviolet B-induced DNA damage in human epidermis is modified by the antioxidants ascorbic acid and D-alpha-tocopherol" J. Investig. Dermatol (2005) 10.1111/j.0022-202x.2004.23560.x

[21]

Stewart "Antioxidant nutrients protect against UVB-induced oxidative damage to DNA of mouse keratinocytes in culture" J. Investig. Dermatol. (1996) 10.1111/1523-1747.ep12339344

[22]

Skin ageing and its treatment

L Baumann

The Journal of Pathology 2007 10.1002/path.2098

[23]

Zussman "Vitamins and photoaging: Do scientific data support their use?" J. Am. Acad. Dermatol. (2010) 10.1016/j.jaad.2009.07.037

[24]

Langton "A new wrinkle on old skin: The role of elastic fibres in skin ageing" Int. J. Cosmet. Sci. (2010) 10.1111/j.1468-2494.2010.00574.x

[25]

Rhie "Aging- and photoaging-dependent changes of enzymic and nonenzymic antioxidants in the epidermis and dermis of human skin in vivo" J. Investig. Dermatol. (2001) 10.1046/j.0022-202x.2001.01469.x

[26]

Shindo "Enzymic and non-enzymic antioxidants in epidermis and dermis of human skin" J. Investig. Dermatol. (1994) 10.1111/1523-1747.ep12371744

[27]

McArdle "UVR-induced oxidative stress in human skin in vivo: Effects of oral vitamin C supplementation" Free Radic. Biol. Med. (2002) 10.1016/s0891-5849(02)01042-0

[28]

Kirk, J.E. (1962). Vitamins and Hormones, Academic Press.

[29]

Schaus "The vitamin C content of human pituitary, cerebral cortex, heart, and skeletal muscle and its relation to age" Am. J. Clin. Nutr. (1957) 10.1093/ajcn/5.1.39

[30]

Yavorsky "The vitamin C content of human tissues" J. Biol. Chem. (1934) 10.1016/s0021-9258(18)75429-x

[31]

Bourne, G.H., and Kidder, G.W. (1953). Chapter 1, pp. 369–471. Biochemistry and Physiology of Nutrition, Academic Press.

[32]

Carr "Human skeletal muscle ascorbate is highly responsive to changes in vitamin C intake and plasma concentrations" Am. J. Clin. Nutr. (2013) 10.3945/ajcn.112.053207

[33]

Shindo "Dose-response effects of acute ultraviolet irradiation on antioxidants and molecular markers of oxidation in murine epidermis and dermis" J. Investig. Dermatol. (1994) 10.1111/1523-1747.ep12373027

[34]

Shindo "Antioxidant defense mechanisms in murine epidermis and dermis and their responses to ultraviolet light" J. Investig. Dermatol. (1993) 10.1111/1523-1747.ep12469048

[35]

Wheeler "Depletion of cutaneous glutathione and the induction of inflammation by 8-methoxypsoralen plus UVA radiation" J. Investig. Dermatol. (1986) 10.1111/1523-1747.ep12456380

[36]

Weber "Vitamin C, uric acid, and glutathione gradients in murine stratum corneum and their susceptibility to ozone exposure" J. Investig. Dermatol. (1999) 10.1046/j.1523-1747.1999.00789.x

[37]

Steiling "Sodium-dependent vitamin C transporter isoforms in skin: Distribution, kinetics, and effect of UVB-induced oxidative stress" Free Radic. Biol. Med. (2007) 10.1016/j.freeradbiomed.2007.05.001

[38]

Lauer "Dose-dependent vitamin C uptake and radical scavenging activity in human skin measured with in vivo electron paramagnetic resonance spectroscopy" Skin Pharmacol. Physiol. (2013) 10.1159/000350833

[39]

Mandl "Vitamin C: Update on physiology and pharmacology" Br. J. Pharmacol. (2009) 10.1111/j.1476-5381.2009.00282.x

[40]

May "The SLC23 family of ascorbate transporters: Ensuring that you get and keep your daily dose of vitamin C" Br. J. Pharmacol. (2011) 10.1111/j.1476-5381.2011.01350.x

[41]

Savini "SVCT1 and SVCT2: Key proteins for vitamin C uptake" Amino Acids (2008) 10.1007/s00726-007-0555-7

[42]

Rajan "Human placental sodium-dependent vitamin C transporter (SVCT2): Molecular cloning and transport function" Biochem. Biophys. Res. Commun. (1999) 10.1006/bbrc.1999.1272

[43]

Levine "In situ kinetics and ascorbic acid requirements" World Rev. Nutr. Diet (1993) 10.1159/000422333

[44]

Levine "Vitamin C pharmacokinetics in healthy volunteers: Evidence for a recommended dietary allowance" Proc. Natl. Acad. Sci. USA (1996) 10.1073/pnas.93.8.3704

[45]

Levine "Ascorbic acid and reaction kinetics in situ: A new approach to vitamin requirements" J. Nutr. Sci. Vitaminol. (1992) 10.3177/jnsv.38.special_169

[46]

Levine "Determination of optimal vitamin C requirements in humans" Am. J. Clin. Nutr. (1995) 10.1093/ajcn/62.6.1347s

[47]

Carr "Toward a new recommended dietary allowance for vitamin C based on antioxidant and health effects in humans" Am. J. Clin. Nutr. (1999) 10.1093/ajcn/69.6.1086

[48]

Carr "A randomized steady-state bioavailability study of synthetic versus natural (kiwifruit-derived) vitamin C" Nutrients (2013) 10.3390/nu5093684

[49]

Costa "Assessment of clinical effects and safety of an oral supplement based on marine protein, vitamin C, grape seed extract, zinc, and tomato extract in the improvement of visible signs of skin aging in men" Clin. Cosmet. Investig. Dermatol. (2015) 10.2147/ccid.s79447

[50]

Fuchs "Modulation of UV-light-induced skin inflammation by d-alpha-tocopherol and l-ascorbic acid: A clinical study using solar simulated radiation" Free Radic. Biol. Med. (1998) 10.1016/s0891-5849(98)00132-4

Showing 50 of 187 references

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