Acute Kidney Injury and Post-Artesunate Delayed Haemolysis in the Course of Plasmodium falciparum Malaria

Alicja Kubanek; Małgorzata Sulima; Aleksandra Szydłowska; Katarzyna Sikorska; Marcin Renke

doi:10.3390/pathogens13100851

journal article Open Access Sep 30, 2024

Acute Kidney Injury and Post-Artesunate Delayed Haemolysis in the Course of Plasmodium falciparum Malaria

Alicja Kubanek

Małgorzata Sulima Aleksandra Szydłowska

Katarzyna Sikorska

Marcin Renke

Pathogens Vol. 13 No. 10 pp. 851 · MDPI AG

View at Publisher Save 10.3390/pathogens13100851

Abstract

Malaria is a major international public health problem. The risk of acquiring malaria varies depending on the intensity of transmission and adherence to mosquito precautions and prophylaxis recommendations. Severe malaria can cause significant multiorgan dysfunction, including acute kidney injury (AKI). Intravenous artesunate is the treatment of choice for severe malaria in non-endemic areas. One of the possible events connected with the lifesaving effects of artemisins is post-artesunate haemolysis (PADH), which may be potentially dangerous and under-recognised. We present a case of a seafarer with severe Plasmodium falciparum malaria complicated with AKI and PADH, with a good response to steroid treatment. This case highlights the need for malaria prophylaxis in business travellers, e.g., seafarers to malara-endemic regions, and close supervision of patients with malaria even after the completion of antimalarial treatment due to the possibility of late complications.

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Details

Published: Sep 30, 2024
Vol/Issue: 13(10)
Pages: 851
License: View

Authors

A

Alicja Kubanek

Division of Occupational, Metabolic and Internal Diseases, University Centre of Maritime and Tropical Medicine, Medical University of Gdansk, 81-519 Gdynia, Poland

M

Małgorzata Sulima

Division of Tropical and Parasitic Diseases, University Centre of Maritime and Tropical Medicine, Medical University of Gdansk, 81-519 Gdynia, Poland

A

Aleksandra Szydłowska

Division of Occupational, Metabolic and Internal Diseases, University Centre of Maritime and Tropical Medicine, Medical University of Gdansk, 81-519 Gdynia, Poland

K

Katarzyna Sikorska

Division of Tropical and Parasitic Diseases, University Centre of Maritime and Tropical Medicine, Medical University of Gdansk, 81-519 Gdynia, Poland; Division of Tropical Medicine and Epidemiology, Institute of Maritime and Tropical Medicine, Faculty of Health Sciences, Medical University of Gdansk, 81-519 Gdynia, Poland

M

Marcin Renke

Division of Occupational, Metabolic and Internal Diseases, University Centre of Maritime and Tropical Medicine, Medical University of Gdansk, 81-519 Gdynia, Poland

Funding

Medical University of Gdańsk Award: 01-30024/0006078

Cite This Article

Alicja Kubanek, Małgorzata Sulima, Aleksandra Szydłowska, et al. (2024). Acute Kidney Injury and Post-Artesunate Delayed Haemolysis in the Course of Plasmodium falciparum Malaria. Pathogens, 13(10), 851. https://doi.org/10.3390/pathogens13100851

Acute Kidney Injury and Post-Artesunate Delayed Haemolysis in the Course of Plasmodium falciparum Malaria

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