Candida albicans Interactions with Mucosal Surfaces during Health and Disease

Spyridoula-Angeliki Nikou; Nessim Kichik; Rhys Brown; Nicole Ponde; Jemima Ho; Julian Naglik; Jonathan Richardson

doi:10.3390/pathogens8020053

journal article Open Access Apr 22, 2019

Candida albicans Interactions with Mucosal Surfaces during Health and Disease

Spyridoula-Angeliki Nikou Nessim Kichik Rhys Brown Nicole Ponde Jemima Ho

Julian Naglik

Jonathan Richardson

Pathogens Vol. 8 No. 2 pp. 53 · MDPI AG

View at Publisher Save 10.3390/pathogens8020053

Abstract

Flexible adaptation to the host environment is a critical trait that underpins the success of numerous microbes. The polymorphic fungus Candida albicans has evolved to persist in the numerous challenging niches of the human body. The interaction of C. albicans with a mucosal surface is an essential prerequisite for fungal colonisation and epitomises the complex interface between microbe and host. C. albicans exhibits numerous adaptations to a healthy host that permit commensal colonisation of mucosal surfaces without provoking an overt immune response that may lead to clearance. Conversely, fungal adaptation to impaired immune fitness at mucosal surfaces enables pathogenic infiltration into underlying tissues, often with devastating consequences. This review will summarise our current understanding of the complex interactions that occur between C. albicans and the mucosal surfaces of the human body.

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Metrics

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Details

Published: Apr 22, 2019
Vol/Issue: 8(2)
Pages: 53
License: View

Authors

S

Spyridoula-Angeliki Nikou

Protein Phosphorylation Laboratory, The Francis Crick Institute, London NW1 1AT, UK

N

Nessim Kichik