A Contemporary View of Respiratory Syncytial Virus (RSV) Biology and Strain-Specific Differences

Mansi Pandya; Sean Callahan; Kyryll Savchenko; Christopher Stobart

doi:10.3390/pathogens8020067

journal article Open Access May 21, 2019

A Contemporary View of Respiratory Syncytial Virus (RSV) Biology and Strain-Specific Differences

Mansi Pandya Sean Callahan Kyryll Savchenko Christopher Stobart

Pathogens Vol. 8 No. 2 pp. 67 · MDPI AG

View at Publisher Save 10.3390/pathogens8020067

Abstract

Respiratory syncytial virus (RSV) is a human respiratory pathogen which remains a leading viral cause of hospitalizations and mortality among infants in their first year of life. Here, we review the biology of RSV, the primary laboratory isolates or strains which have been used to best characterize the virus since its discovery in 1956, and discuss the implications for genetic and functional variations between the established laboratory strains and the recently identified clinical isolates.

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References

130

[1]

Nair "Global and regional burden of hospital admissions for severe acute lower respiratory infections in young children in 2010: A systematic analysis" Lancet (2013) 10.1016/s0140-6736(12)61901-1

[2]

Mazur "The respiratory syncytial virus vaccine landscape: Lessons from the graveyard and promising candidates" Lancet Infect Dis. (2018) 10.1016/s1473-3099(18)30292-5

[3]

Thompson "Mortality Associated with Influenza and Respiratory Syncytial Virus in the United States" JAMA (2003) 10.1001/jama.289.2.179

[4]

Dowell "Respiratory Syncytial Virus Is an Important Cause of Community-Acquired Lower Respiratory Infection among Hospitalized Adults" J. Infect. Dis. (1996) 10.1093/infdis/174.3.456

[5]

Walsh "Is Clinical Recognition of Respiratory Syncytial Virus Infection in Hospitalized Elderly and High-Risk Adults Possible?" J. Infect. Dis. (2007) 10.1086/511986

[6]

Falsey "Respiratory Syncytial Virus Infection in Elderly and High-Risk Adults" N. Engl. J. Med. (2005) 10.1056/nejmoa043951

[7]

Shi "Global, regional, and national disease burden estimates of acute lower respiratory infections due to respiratory syncytial virus in young children in 2015: A systematic review and modelling study" Lancet (2017) 10.1016/s0140-6736(17)30938-8

[8]

Miyairi "Human Genetic Factors and Respiratory Syncytial Virus Disease Severity" Clin. Microbiol. Rev. (2008) 10.1128/cmr.00017-08

[9]

McIntosh "Treatment of respiratory viral infection in an immunodeficient infant with ribavirin aerosol" Am. J. Dis. Child. (1984)

[10]

Macdonald "Respiratory Syncytial Viral Infection in Infants with Congenital Heart Disease" N. Engl. J. Med. (1982) 10.1056/nejm198208123070702

[11]

Cunningham "Rehospitalization for respiratory illness in infants of less than 32 weeks’ gestation" PEDIATRICS (1991)

[12]

Berkovich "Acute respiratory illness in the premature nursery associated with respiratory syncytial virus infections" Pediatrics (1964) 10.1542/peds.34.6.753

[13]

Progress in understanding and controlling respiratory syncytial virus: Still crazy after all these years

Peter L. Collins, José A. Melero

Virus Research 2011 10.1016/j.virusres.2011.09.020

[14]

Ke, Z., Dillard, R.S., Chirkova, T., Leon, F., Stobart, C.C., Hampton, C.M., Strauss, J.D., Rajan, D., Rostad, C.A., and Taylor, J.V. (2018). The Morphology and Assembly of Respiratory Syncytial Virus Revealed by Cryo-Electron Tomography. Viruses, 10. 10.3390/v10080446

[15]

Hotard "A Stabilized Respiratory Syncytial Virus Reverse Genetics System Amenable to Recombination Mediated Mutagenesis" Virology (2012) 10.1016/j.virol.2012.09.022

[16]

Collins "Production of infectious human respiratory syncytial virus from cloned cDNA confirms an essential role for the transcription elongation factor from the 5’ proximal open reading frame of the M2 mRNA in gene expression and provides a capability for vaccine development" Proc. Natl. Acad. Sci. USA (1995) 10.1073/pnas.92.25.11563

[17]

Bitko "Nonstructural proteins of respiratory syncytial virus suppress premature apoptosis by an NF-κB-dependent, interferon-independent mechanism and facilitate virus growth" J. Virol. (2007) 10.1128/jvi.01420-06

[18]

Swedan "Respiratory Syncytial Virus Nonstructural Proteins Decrease Levels of Multiple Members of the Cellular Interferon Pathways" J. Virol. (2009) 10.1128/jvi.00715-09

[19]

Spann "Effects of Nonstructural Proteins NS1 and NS2 of Human Respiratory Syncytial Virus on Interferon Regulatory Factor 3, NF-κB, and Proinflammatory Cytokines" J. Virol. (2005) 10.1128/jvi.79.9.5353-5362.2005

[20]

Lo "Respiratory Syncytial Virus Nonstructural Proteins NS1 and NS2 Mediate Inhibition of Stat2 Expression and α/β Interferon Responsiveness" J. Virol. (2005) 10.1128/jvi.79.14.9315-9319.2005

[21]

Teng "Contribution of the Respiratory Syncytial Virus G Glycoprotein and Its Secreted and Membrane-Bound Forms to Virus Replication In Vitro and In Vivo" Virology (2001) 10.1006/viro.2001.1138

[22]

Comparison of affinity chromatography and adsorption to vaccinia virus recombinant infected cells for depletion of antibodies directed against respiratory syncytial virus glycoproteins present in a human immunoglobulin preparation

Patricia Sastre, José A. Melero, Blanca García‐Barreno et al.

Journal of Medical Virology 2005 10.1002/jmv.20349

[23]

Cortjens "Broadly Reactive Anti-Respiratory Syncytial Virus G Antibodies from Exposed Individuals Effectively Inhibit Infection of Primary Airway Epithelial Cells" J. Virol. (2017) 10.1128/jvi.02357-16

[24]

Prefusion F–specific antibodies determine the magnitude of RSV neutralizing activity in human sera

Joan O. Ngwuta, Man Chen, Kayvon Modjarrad et al.

Science Translational Medicine 2015 10.1126/scitranslmed.aac4241

[25]

Levine "Demonstration that Glycoprotein G Is the Attachment Protein of Respiratory Syncytial Virus" J. Virol. (1987) 10.1099/0022-1317-68-9-2521

[26]

Hendricks "Appearance of a Soluble Form of the G Protein of Respiratory Syncytial Virus in Fluids of Infected Cells" J. Virol. (1987) 10.1099/0022-1317-68-6-1705

[27]

Roberts "The membrane-associated and secreted forms of the respiratory syncytial virus attachment glycoprotein G are synthesized from alternative initiation codons" J. Virol. (1994) 10.1128/jvi.68.7.4538-4546.1994

[28]

Kwilas "Respiratory Syncytial Virus Grown in Vero Cells Contains a Truncated Attachment Protein That Alters Its Infectivity and Dependence on Glycosaminoglycans" J. Virol. (2009) 10.1128/jvi.00986-09

[29]

Melero "Structural, antigenic and immunogenic features of respiratory syncytial virus glycoproteins relevant for vaccine development" Vaccine (2017) 10.1016/j.vaccine.2016.09.045

[30]

Johnson "The G glycoprotein of human respiratory syncytial viruses of subgroups A and B: Extensive sequence divergence between antigenically related proteins" Proc. Natl. Acad. Sci. USA (1987) 10.1073/pnas.84.16.5625

[31]

Collins "Oligomerization and post-translational processing of glycoprotein G of human respiratory syncytial virus: Altered O-glycosylation in the presence of brefeldin A" J. Virol. (1992) 10.1099/0022-1317-73-4-849

[32]

Satake "Respiratory syncytial virus envelope glycoprotein (G) has a novel structure" Nucleic Acids Res. (1985) 10.1093/nar/13.21.7795

[33]

McLellan "Structure and function of respiratory syncytial virus surface glycoproteins" Curr. Top Microbiol. Immunol. (2013)

[34]

Tripp "CX3C chemokine mimicry by respiratory syncytial virus G glycoprotein" Nat. Immunol. (2001) 10.1038/90675

[35]

Hickling "Lung Surfactant Protein A Provides a Route of Entry for Respiratory Syncytial Virus into Host Cells" Viral. Immunol. (2000) 10.1089/vim.2000.13.125

[36]

Barr "Surfactant Protein-A Enhances Uptake of Respiratory Syncytial Virus by Monocytes and U937 Macrophages" Am. J. Respir. Cell Mol. Boil. (2000) 10.1165/ajrcmb.23.5.3771

[37]

Malhotra "Isolation and characterisation of potential respiratory syncytial virus receptor(s) on epithelial cells" Microbes Infect. (2003) 10.1016/s1286-4579(02)00079-5

[38]

Feldman "The Fusion Glycoprotein of Human Respiratory Syncytial Virus Facilitates Virus Attachment and Infectivity via an Interaction with Cellular Heparan Sulfate" J. Virol. (2000) 10.1128/jvi.74.14.6442-6447.2000

[39]

Chirkova "CX3CR1 is an important surface molecule for respiratory syncytial virus infection in human airway epithelial cells" J. Gen. Virol. (2015) 10.1099/vir.0.000218

[40]

Meng "Respiratory Syncytial Virus Attachment Glycoprotein Contribution to Infection Depends on the Specific Fusion Protein" J. Virol. (2016) 10.1128/jvi.02140-15

[41]

Structure of RSV Fusion Glycoprotein Trimer Bound to a Prefusion-Specific Neutralizing Antibody

Jason S. McLellan, Man Chen, Sherman Leung et al.

Science 2013 10.1126/science.1234914

[42]

Stobart "A live RSV vaccine with engineered thermostability is immunogenic in cotton rats despite high attenuation" Nat. Commun. (2016) 10.1038/ncomms13916

[43]

Tayyari "Identification of nucleolin as a cellular receptor for human respiratory syncytial virus" Nat. Med. (2011) 10.1038/nm.2444

[44]

Villenave, R., Nguyen, M.T., Hammonds, J., Sakamoto, K., Lee, S., Meng, J., Currier, M.G., Stobart, C.C., Hotard, A.L., and Pretto, C.D. (2016). EGFR Interacts with the Fusion Protein of Respiratory Syncytial Virus Strain 2-20 and Mediates Infection and Mucin Expression. PLOS Pathog., 12. 10.1371/journal.ppat.1005622

[45]

Respiratory syncytial virus entry and how to block it

Michael B. Battles, Jason S. McLellan

Nature Reviews Microbiology 2019 10.1038/s41579-019-0149-x

[46]

Structure-Based Design of a Fusion Glycoprotein Vaccine for Respiratory Syncytial Virus

Jason S. McLellan, Man Chen, M. Gordon Joyce et al.

Science 2013 10.1126/science.1243283

[47]

Karron, R.A., Buchholz, U.J., and Collins, P.L. (2013). Live-Attenuated Respiratory Syncytial Virus Vaccines, Springer Nature. 10.1007/978-3-642-38919-1_13

[48]

Mufson "Two Distinct Subtypes of Human Respiratory Syncytial Virus" J. Virol. (1985) 10.1099/0022-1317-66-10-2111

[49]

Zlateva "Molecular Evolution and Circulation Patterns of Human Respiratory Syncytial Virus Subgroup A: Positively Selected Sites in the Attachment G Glycoprotein" J. Virol. (2004) 10.1128/jvi.78.9.4675-4683.2004

[50]

Zlateva "Genetic Variability and Molecular Evolution of the Human Respiratory Syncytial Virus Subgroup B Attachment G Protein" J. Virol. (2005) 10.1128/jvi.79.14.9157-9167.2005

Showing 50 of 130 references

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References

Details

Published: May 21, 2019
Vol/Issue: 8(2)
Pages: 67
License: View

Authors

M

Mansi Pandya

Department of Biological Sciences, Butler University, Indianapolis, IN 46208, USA

S

Sean Callahan

Department of Biological Sciences, Butler University, Indianapolis, IN 46208, USA

K

Kyryll Savchenko

Department of Biological Sciences, Butler University, Indianapolis, IN 46208, USA

C

Christopher Stobart

Department of Biological Sciences, Butler University, Indianapolis, IN 46208, USA

Cite This Article

Mansi Pandya, Sean Callahan, Kyryll Savchenko, et al. (2019). A Contemporary View of Respiratory Syncytial Virus (RSV) Biology and Strain-Specific Differences. Pathogens, 8(2), 67. https://doi.org/10.3390/pathogens8020067

A Contemporary View of Respiratory Syncytial Virus (RSV) Biology and Strain-Specific Differences

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