Protection of Piglets with Maternally Derived Antibodies from Sows Inoculated with an Attenuated Live Marker Classical Swine Fever Vaccine (Flc-LOM-BErns)

SeEun Choe; Jihye Shin; Ki-Sun Kim; Sok Song; Ra Mi Cha; Byung-Il Jung; Bang-Hun Hyun; Bong-Kyun Park; Dong-Jun An

doi:10.3390/pathogens9080608

journal article Open Access Jul 27, 2020

Protection of Piglets with Maternally Derived Antibodies from Sows Inoculated with an Attenuated Live Marker Classical Swine Fever Vaccine (Flc-LOM-BErns)

SeEun Choe Jihye Shin

Ki-Sun Kim Sok Song Ra Mi Cha Byung-Il Jung Bang-Hun Hyun Bong-Kyun Park Dong-Jun An

Pathogens Vol. 9 No. 8 pp. 608 · MDPI AG

View at Publisher Save 10.3390/pathogens9080608

Abstract

Here, we investigated the protective efficacy provided by passive immunity induced by a classical swine fever (Flc-LOM-BErns) vaccine with the newly developed DIVA (Differentiating Infected from Vaccinated Animals) function. Ten pigs (aged 40–60 days) with maternally derived antibodies (MDAs) obtained from sows inoculated with the Flc-LOM-BErns vaccine were challenged with virulent classical swine fever virus (CSFV). Pigs with an MDA titer of 6 log2 induced by the Flc-LOM-BErns vaccine were fully protected against virulent CSFV challenge but not the pigs with an MDA titer under 5 log2. In addition, Flc-LOM-BErns vaccine-derived MDAs successfully differentiated vaccinated pigs by bovine viral diarrhea virus (BVDV) Erns/CSFV Erns antibody detection, functioning as a DIVA.

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Comparative Analysis of the Productivity and Immunogenicity of an Attenuated Classical Swine Fever Vaccine (LOM) and an Attenuated Live Marker Classical Swine Fever Vaccine (Flc-LOM-BErns) from Laboratory to Pig Farm

SeEun Choe, Ki-Sun Kim · 2021

Vaccines

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12

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25

References

Details

Published: Jul 27, 2020
Vol/Issue: 9(8)
Pages: 608
License: View

Authors

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SeEun Choe