Mycoplasma bovis Infections—Occurrence, Diagnosis and Control

Katarzyna Dudek; Robin A. J. Nicholas; Ewelina Szacawa; Dariusz Bednarek

doi:10.3390/pathogens9080640

journal article Open Access Aug 06, 2020

Mycoplasma bovis Infections—Occurrence, Diagnosis and Control

Katarzyna Dudek

Robin A. J. Nicholas Ewelina Szacawa

Dariusz Bednarek

Pathogens Vol. 9 No. 8 pp. 640 · MDPI AG

View at Publisher Save 10.3390/pathogens9080640

Abstract

Mycoplasma bovis is a cause of bronchopneumonia, mastitis and arthritis but may also affect other main organs in cattle such us the eye, ear or brain. Despite its non-zoonotic character, M. bovis infections are responsible for substantial economic health and welfare problems worldwide. M. bovis has spread worldwide, including to countries for a long time considered free of the pathogen. Control of M. bovis infections is hampered by a lack of effective vaccines and treatments due to increasing trends in antimicrobial resistance. This review summarizes the latest data on the epizootic situation of M. bovis infections and new sources/routes of transmission of the infection, and discusses the progress in diagnostics. The review includes various recommendations and suggestions which could be applied to infection control programs.

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References

87

[1]

Ministry for Primary Industries (2020, June 20). First Case of Mycoplasma Bovis Found in Bay of Plenty. Available online: https://www.tvnz.co.nz/one-news/new-zealand/first-case-mycoplasma-bovis-found-in-bay-plenty.

[2]

Haapala "Semen as a source of Mycoplasma bovis mastitis in dairy herds" Vet. Microbiol. (2018) 10.1016/j.vetmic.2018.02.005

[3]

Nicholas, R., Ayling, R., and McAuliffe, L. (2008). Mycoplasma Diseases of Ruminants, CABI Publishing. [1st ed.]. 10.1079/9780851990125.0000

[4]

Mycoplasma mastitis in cattle: To cull or not to cull

Robin A.J. Nicholas, Larry K. Fox, Inna Lysnyansky

The Veterinary Journal 2016 10.1016/j.tvjl.2016.08.001

[5]

Klein "New antimicrobial susceptibility data from monitoring of Mycoplasma bovis isolated in Europe" Vet. Microbiol. (2019) 10.1016/j.vetmic.2019.108432

[6]

Houlihan "Mastitis and arthritis in two dairy herds caused by Mycoplasma bovis" Vet. Rec. (2007) 10.1136/vr.160.4.126

[7]

Maeda "Mycoplasma bovis-associated suppurative otitis media and pneumonia in bull calves" J. Comp. Pathol. (2003) 10.1016/s0021-9975(03)00009-4

[8]

Alberti "Molecular and antigenic characterization of a Mycoplasma bovis strain causing an outbreak of infectious keratoconjunctivitis" J. Vet. Diagn. Invest. (2006) 10.1177/104063870601800106

[9]

Kinde "Mycoplasma bovis associated with decubital abscesses in Holstein calves" J. Vet. Diagn. Invest. (1993) 10.1177/104063879300500209

[10]

Kanda "Bovine Endocarditis Associated with Mycoplasma bovis" J. Comp. Pathol. (2019) 10.1016/j.jcpa.2019.07.003

[11]

Pardon "Pathogen-specific risk factors in acute outbreaks of respiratory disease in calves" J. Dairy Sci. (2020) 10.3168/jds.2019-17486

[12]

Oliveira "Mycoplasma bovis and viral agents associated with the development of bovine respiratory disease in adult dairy cows" Transbound. Emerg. Dis. (2019) 10.1111/tbed.13223

[13]

Hazelton "Whole dairy herd sampling to detect subclinical intramammary Mycoplasma bovis infection after clinical mastitis outbreaks" Vet. Microbiol. (2020) 10.1016/j.vetmic.2020.108662

[14]

Punyapornwithaya "Association between an outbreak strain causing mycoplasma bovis mastitis and its asymptomatic carriage in the herd: A case study from Idaho, USA" Prev. Vet. Med. (2010) 10.1016/j.prevetmed.2009.08.008

[15]

Ayling "Changes in antimicrobial susceptibility of Mycoplasma bovis isolates from Great Britain" Vet. Rec. (2014) 10.1136/vr.102303

[16]

Gautier-Bouchardon, A.V., Ferré, S., Le Grand, D., Paoli, A., Gay, E., and Poumarat, F. (2014). Overall decrease in the susceptibility of Mycoplasma bovis to antimicrobials over the past 30 years in France. PLoS ONE, 9. 10.1371/journal.pone.0087672

[17]

Sulyok, K.M., Kreizinger, Z., Fekete, L., Hrivnák, V., Magyar, T., Jánosi, S., Schweitzer, N., Turcsányi, I., Makrai, L., and Erdélyi, K. (2014). Antibiotic susceptibility profiles of Mycoplasma bovis strains isolated from cattle in Hungary, Central Europe. BMC Vet. Res., 10. 10.1186/s12917-014-0256-x

[18]

Ayling "Comparison of in vitro activity of danofloxacin, florfenicol, oxytetracycline, spectinomycin and tilmicosin against recent field isolates of Mycoplasma bovis" Vet. Rec. (2000) 10.1136/vr.146.26.745

[19]

Dudek, K., Bednarek, D., Ayling, R.D., Kycko, A., and Reichert, M. (2019). Preliminary study on the effects of enrofloxacin, flunixin meglumine and pegbovigrastim on Mycoplasma bovis pneumonia. BMC Vet. Res., 15. 10.1186/s12917-019-2122-3

[20]

Ridley "Mycoplasma bovis investigations in cattle" Vet. Rec. (2018) 10.1136/vr.k3722

[21]

Dudek "An experimental vaccine composed of two adjuvants gives protection against Mycoplasma bovis in calves" Vaccine (2016) 10.1016/j.vaccine.2016.04.087

[22]

Nicholas "An experimental vaccine for calf pneumonia caused by Mycoplasma bovis: Clinical, cultural, serological and pathological findings" Vaccine (2002) 10.1016/s0264-410x(02)00340-7

[23]

Pohjanvirta "Characterisation of the course of Mycoplasma bovis infection in naturally infected dairy herds" Vet. Microbiol. (2019) 10.1016/j.vetmic.2019.03.007

[24]

Nicholas "Bovine mycoplasmosis: Silent and deadly" Vet. Rec. (2011) 10.1136/vr.d2468

[25]

(2020, August 05). Technical Advisory Group (TAG) Report, Available online: https://www.mpi.govt.nz/dmsdocument/37754-report-of-the-mycoplasma-bovis-technical-advisory-group-tag-in-response-to-the-terms-of-reference-june-2019-18-october-2019.

[26]

Timonen "Dynamics of the within-herd prevalence of Mycoplasma bovis intramammary infection in endemically infected dairy herds" Vet. Microbiol. (2020) 10.1016/j.vetmic.2020.108608

[27]

Gille "The presence of Mycoplasma bovis in colostrum" Vet. Res. (2020) 10.1186/s13567-020-00778-w

[28]

Passchyn "Between-herd prevalence of Mycoplasma bovis in bulk milk in Flanders, Belgium" Res. Vet. Sci. (2012) 10.1016/j.rvsc.2011.03.016

[29]

Stott "Influence of environment on passive immunity in calves" J. Dairy Sci. (1976) 10.3168/jds.s0022-0302(76)84360-3

[30]

Alabdullah, H., Schneider, C., and Fox, L. (2011, January 22–24). Effect of dexamethasone administration on shedding of Mycoplasma bovis in calves. Proceedings of the Third International Symposium on Mastitis and Milk Quality, St. Louis, MO, USA.

[31]

Alabdullah "Effects of dexamethasone and Mycoplasma bovis on bovine neutrophil function in vitro" Vet. Immunol. Immunopathol. (2015) 10.1016/j.vetimm.2014.12.010

[32]

Ayling "Mycoplasma species and related organisms isolated from ruminants in Britain between 1990 and 2000" Vet. Rec. (2004) 10.1136/vr.155.14.413

[33]

Gagea "Naturally occurring Mycoplasma bovis-associated pneumonia and polyarthritis in feedlot beef calves" J. Vet. Diagn. Invest. (2006) 10.1177/104063870601800105

[34]

Ryan "Morphologic changes following intraarticular inoculation of Mycoplasma bovis in calves" Vet. Pathol. (1983) 10.1177/030098588302000410

[35]

Foster "Mycoplasma bovis and otitis in dairy calves in the United Kingdom" Vet. J. (2009) 10.1016/j.tvjl.2007.10.020

[36]

Ayling "Mycoplasma bovis isolated from brain tissue of calves" Vet. Rec. (2005) 10.1136/vr.156.12.391-b

[37]

Kanci "Reproduction of respiratory mycoplasmosis in calves by exposure to an aerosolised culture of Mycoplasma bovis" Vet. Microbiol. (2017) 10.1016/j.vetmic.2017.09.013

[38]

Jasper "Epidemiologic observations on mycoplasma mastitis" Cornell Vet. (1974)

[39]

Maunsell "Mycoplasma bovis infections in cattle. ACVIM Consensus Statement" J. Vet. Intern. Med. (2011) 10.1111/j.1939-1676.2011.0750.x

[40]

Lysnyansky "An overview of Mycoplasma bovis mastitis in Israel (2004–2014)" Vet. J. (2016) 10.1016/j.tvjl.2015.10.057

[41]

Hermeyer "Demonstration of Mycoplasma bovis by immunohistochemistry and in situ hybridization in an aborted bovine fetus and neonatal calf" J. Vet. Diagn. Invest. (2012) 10.1177/1040638711435145

[42]

Sachse "Mycoplasma bovis as an agent of mastitis, pneumonia, arthritis and genital disorders in cattle" Rev. Sci. Tech. Off. Int. Epiz. (1996) 10.20506/rst.15.4.987

[43]

Poumarat "Application of dot immunobinding on membrane filtration (MF dot) to the study of relationships within “M. mycoides cluster” and within “glucose and arginine-negative cluster” of ruminant mycoplasmas" Vet. Microbiol. (1992) 10.1016/0378-1135(92)90159-q

[44]

Miles, R.J., and Nicholas, R.A.J. (1998). Recovery of mycoplasmas from animals. Mycoplasma Protocols, Humana Press. 10.1385/0896035255

[45]

Behera "Development of real-time PCR assay for the detection of Mycoplasma bovis" Trop. Anim. Health Prod. (2018) 10.1007/s11250-018-1510-1

[46]

Zaheer "A direct qPCR screening approach to improve the efficiency of Mycoplasma bovis isolation in the frame of a broad surveillance study" J. Microbiol. Methods (2020) 10.1016/j.mimet.2019.105805

[47]

Appelt "Development and comparison of loop-mediated isothermal amplification and quantitative polymerase chain reaction assays for the detection of Mycoplasma bovis in milk" J. Dairy Sci. (2019) 10.3168/jds.2018-15306

[48]

Parker, A.M., House, J.K., Hazelton, M.S., Bosward, K.L., and Sheehy, P.A. (2017). Comparison of culture and a multiplex probe PCR for identifying Mycoplasma species in bovine milk, semen and swab samples. PLoS ONE, 12. 10.1371/journal.pone.0173422

[49]

Pansri "Evaluation of novel multiplex qPCR assays for diagnosis of pathogens associated with the bovine respiratory disease complex" Vet. J. (2020) 10.1016/j.tvjl.2020.105425

[50]

Conrad "A Sensitive and Accurate Recombinase Polymerase Amplification Assay for Detection of the Primary Bacterial Pathogens Causing Bovine Respiratory Disease" Front. Vet. Sci. (2020) 10.3389/fvets.2020.00208

Showing 50 of 87 references

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Details

Published: Aug 06, 2020
Vol/Issue: 9(8)
Pages: 640
License: View

Authors

K

Katarzyna Dudek

Department of Cattle and Sheep Diseases, National Veterinary Research Institute, 57 Partyzantów Avenue, 24100 Pulawy, Poland

R

Robin A. J. Nicholas

The Oaks, Nutshell Lane, Farnham, Surrey GU9 0HG, UK

E

Ewelina Szacawa

Department of Cattle and Sheep Diseases, National Veterinary Research Institute, 57 Partyzantów Avenue, 24100 Pulawy, Poland

D

Dariusz Bednarek

Department of Cattle and Sheep Diseases, National Veterinary Research Institute, 57 Partyzantów Avenue, 24100 Pulawy, Poland

Cite This Article

Katarzyna Dudek, Robin A. J. Nicholas, Ewelina Szacawa, et al. (2020). Mycoplasma bovis Infections—Occurrence, Diagnosis and Control. Pathogens, 9(8), 640. https://doi.org/10.3390/pathogens9080640

Mycoplasma bovis Infections—Occurrence, Diagnosis and Control

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