Selenium in Prostate Cancer: Prevention, Progression, and Treatment

Jinjiang Jiang; Bo Chen; Bo Tang; Qiang Wei

doi:10.3390/ph16091250

journal article Open Access Sep 05, 2023

Selenium in Prostate Cancer: Prevention, Progression, and Treatment

Jinjiang Jiang Bo Chen

Bo Tang

Qiang Wei

Pharmaceuticals Vol. 16 No. 9 pp. 1250 · MDPI AG

View at Publisher Save 10.3390/ph16091250

Abstract

Selenium, a trace mineral with various biological functions, has become a focal point in prostate cancer research. This review aims to present a comprehensive overview of selenium’s involvement in prostate cancer, covering its impact on prevention, development, treatment, and underlying mechanisms. Observational studies have revealed a link between selenium levels and selenoproteins with prostate cancer progression. However, randomized controlled studies have shown that selenium supplementation does not prevent prostate cancer (HR: 0.95; 95% CI 0.80–1.13). This discrepancy might be attributed to selenoprotein single nucleotide polymorphisms. In the context of combinatorial therapy, selenium has demonstrated promising synergistic potential in the treatment of prostate cancer. Emerging evidence highlights the significant role of selenium and selenoproteins in prostate cancer, encompassing AR signaling, antioxidative properties, cell death, cell cycle regulation, angiogenesis, epigenetic regulation, immunoregulation, epithelial–mesenchymal transformation, and redox signal. In conclusion, selenium’s diverse properties make it a promising trace mineral in prostate cancer prevention, development, and treatment and as a platform for exploring novel agents.

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References

Details

Published: Sep 05, 2023
Vol/Issue: 16(9)
Pages: 1250
License: View

Authors

J

Jinjiang Jiang

Department of Urology, West China Hospital of Sichuan University, No. 37, Guoxue Lane, Chengdu 610041, China; Institute of Urology, West China Hospital of Sichuan University, Chengdu 610041, China

B

Bo Chen

Department of Urology, West China Hospital of Sichuan University, No. 37, Guoxue Lane, Chengdu 610041, China; Institute of Urology, West China Hospital of Sichuan University, Chengdu 610041, China

B

Bo Tang

Department of Urology, West China Hospital of Sichuan University, No. 37, Guoxue Lane, Chengdu 610041, China; Institute of Urology, West China Hospital of Sichuan University, Chengdu 610041, China

Q

Qiang Wei

Department of Urology, West China Hospital of Sichuan University, No. 37, Guoxue Lane, Chengdu 610041, China; Institute of Urology, West China Hospital of Sichuan University, Chengdu 610041, China

Funding

National Natural Science Foundation of China Award: 81974098

Sichuan Science and Technology Program Award: 81974098

Cite This Article

Jinjiang Jiang, Bo Chen, Bo Tang, et al. (2023). Selenium in Prostate Cancer: Prevention, Progression, and Treatment. Pharmaceuticals, 16(9), 1250. https://doi.org/10.3390/ph16091250

Selenium in Prostate Cancer: Prevention, Progression, and Treatment

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