Sustained Release Drug Delivery Applications of Polyurethanes

Michael B. Lowinger; Stephanie E. Barrett; Feng Zhang; Robert O. Williams

doi:10.3390/pharmaceutics10020055

journal article Open Access May 09, 2018

Sustained Release Drug Delivery Applications of Polyurethanes

Michael B. Lowinger

Stephanie E. Barrett Feng Zhang

Robert O. Williams

Pharmaceutics Vol. 10 No. 2 pp. 55 · MDPI AG

View at Publisher Save 10.3390/pharmaceutics10020055

Abstract

Since their introduction over 50 years ago, polyurethanes have been applied to nearly every industry. This review describes applications of polyurethanes to the development of modified release drug delivery. Although drug delivery research leveraging polyurethanes has been ongoing for decades, there has been renewed and substantial interest in the field in recent years. The chemistry of polyurethanes and the mechanisms of drug release from sustained release dosage forms are briefly reviewed. Studies to assess the impact of intrinsic drug properties on release from polyurethane-based formulations are considered. The impact of hydrophilic water swelling polyurethanes on drug diffusivity and release rate is discussed. The role of pore formers in modulating drug release rate is examined. Finally, the value of assessing mechanical properties of the dosage form and approaches taken in the literature are described.

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References

96

[1]

Engels "Polyurethanes: Versatile Materials and Sustainable Problem Solvers for Today’s Challenges" Angew. Chem. Int. Ed. (2013) 10.1002/anie.201302766

[2]

Bayer "Das Di-Isocyanat-Polyadditionsverfahren (Polyurethane)" Angew. Chem. (1947) 10.1002/ange.19470590901

[3]

Cherng "Polyurethane-based drug delivery systems" Int. J. Pharm. (2013) 10.1016/j.ijpharm.2013.04.063

[4]

Seo "Polyurethane membrane with porous surface for controlled drug release in drug eluting stent" Biomater. Res. (2014) 10.1186/2055-7124-18-15

[5]

Guo "Tailored drug release from biodegradable stent coatings based on hybrid polyurethanes" J. Control. Release (2009) 10.1016/j.jconrel.2009.04.016

[6]

Chen "Preparation and characterization of PEG-modified polyurethane pressure-sensitive adhesives for transdermal drug delivery" Drug Dev. Ind. Pharm. (2009) 10.1080/03639040802512235

[7]

Li "Sustained release of vancomycin from polyurethane scaffolds inhibits infection of bone wounds in a rat femoral segmental defect model" J. Control. Release (2010) 10.1016/j.jconrel.2010.04.002

[8]

Gorna "Preparation, degradation, and calcification of biodegradable polyurethane foams for bone graft substitutes" J. Biomed. Mater. Res. (2003) 10.1002/jbm.a.10148

[9]

Li "The effects of rhBMP-2 released from biodegradable polyurethane/microsphere composite scaffolds on new bone formation in rat femora" Biomaterials (2009) 10.1016/j.biomaterials.2009.08.038

[10]

Martinelli "Water state effect on drug release from an antibiotic loaded polyurethane matrix containing albumin nanoparticles" Int. J. Pharm. (2011) 10.1016/j.ijpharm.2011.01.029

[11]

Wang "Temperature- and pH-responsive nanoparticles of biocompatible polyurethanes for doxorubicin delivery" Int. J. Pharm. (2013) 10.1016/j.ijpharm.2012.12.021

[12]

Basak "Sustained release of antibiotic from polyurethane coated implant materials" J. Mater. Sci. Mater. Med. (2009) 10.1007/s10856-008-3521-3

[13]

Moura "Local Drug Delivery System: Inhibition of Inflammatory Angiogenesis in a Murine Sponge Model by Dexamethasone-Loaded Polyurethane Implants" J. Pharm. Sci. (2011) 10.1002/jps.22497

[14]

Johnson "Segmented polyurethane intravaginal rings for the sustained combined delivery of antiretroviral agents dapivirine and tenofovir" Eur. J. Pharm. Sci. (2010) 10.1016/j.ejps.2009.11.007

[15]

Verstraete "Thermoplastic polyurethane-based intravaginal rings for prophylaxis and treatment of (recurrent) bacterial vaginosis" Int. J. Pharm. (2017) 10.1016/j.ijpharm.2017.06.076

[16]

Intravaginal ring delivery of tenofovir disoproxil fumarate for prevention of HIV and herpes simplex virus infection

P. M. M. Mesquita, R. Rastogi, T. J. Segarra et al.

Journal of Antimicrobial Chemotherapy 2012 10.1093/jac/dks097

[17]

Gupta "Polyurethane Intravaginal Ring for Controlled Delivery of Dapivirine, a Nonnucleoside Reverse Transcriptase Inhibitor of HIV-1" J. Pharm. Sci. (2008) 10.1002/jps.21331

[18]

Traore "Impact of Hydroxychloroquine-Loaded Polyurethane Intravaginal Rings on Lactobacilli" Antimicrob. Agents Chemother. (2015) 10.1128/aac.01819-15

[19]

Smith "Intravaginal ring eluting tenofovir disoproxil fumarate completely protects macaques from multiple vaginal simian-HIV challenges" Proc. Natl. Acad. Sci. USA (2013) 10.1073/pnas.1311355110

[20]

Johnson "A 90-day tenofovir reservoir intravaginal ring for mucosal HIV prophylaxis" Antimicrob. Agents Chemother. (2012) 10.1128/aac.01431-12

[21]

Keller "A phase 1 randomized placebo-controlled safety and pharmacokinetic trial of a tenofovir disoproxil fumarate vaginal ring" AIDS (2016) 10.1097/qad.0000000000000979

[22]

Teller "Controlling the hydration rate of a hydrophilic matrix in the core of an intravaginal ring determines antiretroviral release" J. Control. Release (2016) 10.1016/j.jconrel.2015.12.035

[23]

Smith "Tenofovir disoproxil fumarate intravaginal ring protects high-dose depot medroxyprogesterone acetate-treated macaques from multiple SHIV exposures" J. Acquir. Immune Defic. Syndr. (2015) 10.1097/qai.0000000000000402

[24]

Clark "A hot-melt extruded intravaginal ring for the sustained delivery of the antiretroviral microbicide UC781" J. Pharm. Sci. (2012) 10.1002/jps.22781

[25]

Friend "Multipurpose prevention technologies: Products in development" Antiviral Res. (2013) 10.1016/j.antiviral.2013.09.030

[26]

Claeys "Release characteristics of polyurethane tablets containing dicarboxylic acids as release modifiers—A case study with diprophylline" Int. J. Pharm. (2014) 10.1016/j.ijpharm.2014.10.046

[27]

Lazarus "Factors Influencing the Release of a Drug from a Prolonged-Action Matrix" J. Pharm. Sci. (1964) 10.1002/jps.2600530722

[28]

Anderson "Recent advances in biomedical polyurethane biostability and biodegradation" Polym. Int. (1998) 10.1002/(sici)1097-0126(199807)46:3<163::aid-pi972>3.0.co;2-9

[29]

Cooper, S.L., and Guan, J. (2016). Advances in Polyurethane Biomaterials, Woodhead Publishing.

[30]

Boretos "Segmented polyurethane: A polyether polymer. An initial evalution for biomedical applications" J. Biomed. Mater. Res. (1968) 10.1002/jbm.820020109

[31]

Gogolewski "Selected topics in biomedical polyurethanes. A review" Colloid Polym. Sci. (1989) 10.1007/bf01410115

[32]

Gunatillake "Designing Biostable Polyurethane Elastomers for Biomedical Implants" Aust. J. Chem. (2003) 10.1071/ch02168

[33]

Lamba, N.M.K., Woodhouse, K.A., and Cooper, S.L. (1997). Polyurethanes in Biomedical Applications, CRC Press.

[34]

Vermette, P., Griesser, H.J., Laroche, G., and Guidoin, R. (2001). Biomedical Applications of Polyurethanes, Landes Bioscience.

[35]

Irusta "Aromatic poly(ester–urethanes): Effect of the polyol molecular weight on the photochemical behaviour" Polymer (2000) 10.1016/s0032-3861(99)00548-0

[36]

DiBattista "Aliphatic TPUs for light-stable applications" Rubber World (2003)

[37]

Szycher "An Assessment of 2,4 TDA Formation from Surgitek Polyurethane Foam under Simulated Physiological Conditions" J. Biomater. Appl. (1991) 10.1177/088532829100500404

[38]

Hirvonen "Exposure to 4,4′-methylenediphenyl diisocyanate (MDI) during moulding of rigid polyurethane foam: Determination of airborne MDI and urinary 4,4′-methylenedianiline (MDA)" Analyst (2001) 10.1039/b009549o

[39]

Morphology of and release behavior from porous polyurethane microspheres

Esmaiel Jabbari, Maziar Khakpour

Biomaterials 2000 10.1016/s0142-9612(00)00135-6

[40]

Thompson "Effects of hydrolysis-induced molecular weight changes on the phase separation of a polyester polyurethane" Polym. Degrad. Stab. (2006) 10.1016/j.polymdegradstab.2006.05.019

[41]

Saad "Development of degradable polyesterurethanes for medical applications: In vitro and in vivo evaluations" J. Biomed. Mater. Res. (1997) 10.1002/(sici)1097-4636(199707)36:1<65::aid-jbm8>3.0.co;2-j

[42]

Kaur "Engineering a degradable polyurethane intravaginal ring for sustained delivery of dapivirine" Drug Deliv. Transl. Res. (2011) 10.1007/s13346-011-0027-1

[43]

Yu "Phenylalanine-Based Poly(ester urea): Synthesis, Characterization, and in vitro Degradation" Macromolecules (2014) 10.1021/ma401752b

[44]

"Assessing the progress of degradation in polyurethanes by chemiluminescence and thermal analysis. II. Flexible polyether- and polyester-type polyurethane foams" Polym. Degrad. Stab. (2011) 10.1016/j.polymdegradstab.2011.01.012

[45]

Burgaz "Comparison of hydrogen bonding in polydimethylsiloxane and polyether based urethane and urea copolymers" Polymer (2000) 10.1016/s0032-3861(99)00245-1

[46]

Wiggins "Biodegradation of polyether polyurethane inner insulation in bipolar pacemaker leads" J. Biomed. Mater. Res. (2001) 10.1002/1097-4636(2001)58:3<302::aid-jbm1021>3.0.co;2-y

[47]

Christenson "Poly(carbonate urethane) and poly(ether urethane) biodegradation: In vivo studies" J. Biomed. Mater. Res. Part A (2004) 10.1002/jbm.a.30002

[48]

Ikeda "Polyurethane elastomer with PEO-PTMO-PEO soft segment for sustained release of drugs" Biomaterials (1990) 10.1016/0142-9612(90)90077-4

[49]

Foreign body reaction to biomaterials

James M. Anderson, Analiz Rodriguez, David T. Chang

Seminars in Immunology 2008 10.1016/j.smim.2007.11.004

[50]

Kricheldorf, H.R., Quirk, R.P., and Holden, G. (2004). Thermoplastic Elastomers, Hanser Gardner Publications.

Showing 50 of 96 references

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Details

Published: May 09, 2018
Vol/Issue: 10(2)
Pages: 55
License: View

Authors

M

Michael B. Lowinger

College of Pharmacy, The University of Texas at Austin, 2409 University Avenue, Austin, TX 78712, USA; MRL, Merck & Co., Inc., 126 E. Lincoln Ave, Rahway, NJ 07065, USA

S

Stephanie E. Barrett

MRL, Merck & Co., Inc., 126 E. Lincoln Ave, Rahway, NJ 07065, USA

F

Feng Zhang

College of Pharmacy, The University of Texas at Austin, 2409 University Avenue, Austin, TX 78712, USA

R

Robert O. Williams

College of Pharmacy, The University of Texas at Austin, 2409 University Avenue, Austin, TX 78712, USA

Cite This Article

Michael B. Lowinger, Stephanie E. Barrett, Feng Zhang, et al. (2018). Sustained Release Drug Delivery Applications of Polyurethanes. Pharmaceutics, 10(2), 55. https://doi.org/10.3390/pharmaceutics10020055

Sustained Release Drug Delivery Applications of Polyurethanes

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