Poly Lactic-co-Glycolic Acid (PLGA) as Biodegradable Controlled Drug Delivery Carrier

Hirenkumar K. Makadia; Steven J. Siegel

doi:10.3390/polym3031377

journal article Open Access Aug 26, 2011

Poly Lactic-co-Glycolic Acid (PLGA) as Biodegradable Controlled Drug Delivery Carrier

Hirenkumar K. Makadia Steven J. Siegel

Polymers Vol. 3 No. 3 pp. 1377-1397 · MDPI AG

View at Publisher Save 10.3390/polym3031377

Abstract

In past two decades poly lactic-co-glycolic acid (PLGA) has been among the most attractive polymeric candidates used to fabricate devices for drug delivery and tissue engineering applications. PLGA is biocompatible and biodegradable, exhibits a wide range of erosion times, has tunable mechanical properties and most importantly, is a FDA approved polymer. In particular, PLGA has been extensively studied for the development of devices for controlled delivery of small molecule drugs, proteins and other macromolecules in commercial use and in research. This manuscript describes the various fabrication techniques for these devices and the factors affecting their degradation and drug release.

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References

Details

Published: Aug 26, 2011
Vol/Issue: 3(3)
Pages: 1377-1397
License: View

Authors

H

Hirenkumar K. Makadia

Materials Science and Engineering, University of Pennsylvania, Philadelphia, PA 19104, USA

S

Steven J. Siegel

Translational Neuroscience Program, Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA

Cite This Article

Hirenkumar K. Makadia, Steven J. Siegel (2011). Poly Lactic-co-Glycolic Acid (PLGA) as Biodegradable Controlled Drug Delivery Carrier. Polymers, 3(3), 1377-1397. https://doi.org/10.3390/polym3031377

Poly Lactic-co-Glycolic Acid (PLGA) as Biodegradable Controlled Drug Delivery Carrier

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