journal article
Open Access
Dec 07, 2021
Maternal HPV Infection: Effects on Pregnancy Outcome
Abstract
The human papilloma virus (HPV) infection, caused by a ubiquitous virus typically transmitted through the direct contact of infected organs, either through the skin or mucosa, is the most common sexually transmitted infection, placing young women at a high risk of contracting it. Although the vast majority of cases spontaneously clear within 1–2 years, persistent HPV infection remains a serious concern, as it has repeatedly been linked to the development of multiple malignancies, including cervical, anogenital, and oropharyngeal cancers. Additionally, more recent data suggest a harmful effect of HPV infection on pregnancy. As the maternal hormonal environment and immune system undergo significant changes during pregnancy, the persistence of HPV is arguably favored. Various studies have reported an increased risk of adverse pregnancy outcomes among HPV-positive women, with the clinical impact encompassing a range of conditions, including preterm birth, miscarriage, pregnancy-induced hypertensive disorders (PIHD), intrauterine growth restriction (IUGR), low birth weight, the premature rupture of membranes (PROM), and fetal death. Therefore, understanding the mechanisms employed by HPV that negatively impact pregnancy and assessing potential approaches to counteract them would be of interest in the quest to optimize pregnancy outcomes and improve child survival and health.
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References
197
[1]
McQuillan, G., Kruszon-Moran, D., Markowitz, L.E., Unger, E.R., and Paulose-Ram, R. (2017). Prevalence of HPV in Adults Aged 18–69: United States, 2011–2014, NCHS Data Brief.
[2]
Sehnal "The association among cervical, anal, and oral HPV infections in high-risk and low-risk women" Eur. J. Obstet. Gynecol. Reprod. Biol. X (2019)
[3]
Otter "The Human Papillomavirus as a Common Pathogen in Oropharyngeal, Anal and Cervical Cancers" Clin. Oncol. (2019) 10.1016/j.clon.2018.10.004
[4]
Park "Carcinogenic risk of human papillomavirus (HPV) genotypes and potential effects of HPV vaccines in Korea" Sci. Rep. (2019) 10.1038/s41598-019-49060-w
[5]
Classification of papillomaviruses
Ethel-Michele de Villiers, Claude Fauquet, Thomas R Broker et al.
Virology
2004
10.1016/j.virol.2004.03.033
[6]
Braaten "Human Papillomavirus (HPV), HPV-Related Disease, and the HPV Vaccine" Rev. Obstet. Gynecol. (2008)
[7]
Egawa "Human Papillomaviruses; Epithelial Tropisms, and the Development of Neoplasia" Viruses (2015) 10.3390/v7072802
[8]
Chen "Classification and evolution of human papillomavirus genome variants: Alpha-5 (HPV26, 51, 69, 82), Alpha-6 (HPV30, 53, 56, 66), Alpha-11 (HPV34, 73), Alpha-13 (HPV54) and Alpha-3 (HPV61)" Virology (2018) 10.1016/j.virol.2018.01.002
[9]
Eklund "Towards quality and order in human papillomavirus research" Virology (2018) 10.1016/j.virol.2018.04.003
[10]
Forslund "The nasal mucosa contains a large spectrum of human papillomavirus types from the Betapapillomavirus and Gammapapillomavirus genera" J. Infect. Dis. (2013) 10.1093/infdis/jit326
[11]
Hampras "Prevalence and Concordance of Cutaneous Beta Human Papillomavirus Infection at Mucosal and Cutaneous Sites" J. Infect. Dis. (2017) 10.1093/infdis/jix245
[12]
Accardi "Cutaneous HPV and skin cancer" Presse Med. (2014) 10.1016/j.lpm.2014.08.008
[13]
Ramoz "Mutations in two adjacent novel genes are associated with epidermodysplasia verruciformis" Nat. Genet. (2002) 10.1038/ng1044
[14]
Bottalico "The oral cavity contains abundant known and novel human papillomaviruses from the Betapapillomavirus and Gammapapillomavirus genera" J. Infect. Dis. (2011) 10.1093/infdis/jir383
[15]
Gheit "Alpha, beta and gamma Human Papillomaviruses in the anal canal of HIV-infected and uninfected men who have sex with men" J. Infect. (2015) 10.1016/j.jinf.2015.02.001
[16]
Gheit "Mucosal and Cutaneous Human Papillomavirus Infections and Cancer Biology" Front. Oncol. (2019) 10.3389/fonc.2019.00355
[17]
Plasmeijer "Epidemiology of cutaneous human papillomavirus infections" Cancer Treat. Res. (2009) 10.1007/978-0-387-78574-5_13
[18]
Weissenborn "Prevalence and associated factors of betapapillomavirus infections in individuals without cutaneous squamous cell carcinoma" J. Gen. Virol. (2009) 10.1099/vir.0.010017-0
[19]
Struijk "Betapapillomaviruses frequently persist in the skin of healthy individuals" J. Gen. Virol. (2007) 10.1099/vir.0.82732-0
[20]
Moscicki "Prevalence and Transmission of Beta and Gamma Human Papillomavirus in Heterosexual Couples" Open Forum Infect. Dis. (2017) 10.1093/ofid/ofw216
[21]
Neale "Multicenter study of the association between betapapillomavirus infection and cutaneous squamous cell carcinoma" Cancer Res. (2010) 10.1158/0008-5472.can-10-0352
[22]
Weissenborn "Beta-papillomavirus DNA loads in hair follicles of immunocompetent people and organ transplant recipients" Med. Microbiol. Immunol. (2012) 10.1007/s00430-011-0212-3
[23]
Michael, K.M., Waterboer, T., Sehr, P., Rother, A., Reidel, U., Boeing, H., Bravo, I.G., Schlehofer, J., Gärtner, B.C., and Pawlita, M. (2008). Seroprevalence of 34 human papillomavirus types in the German general population. PLoS Pathog., 4.
10.1371/journal.ppat.1000091
[24]
Brown "Skin cancer in solid organ transplant recipients: Advances in therapy and management: Part I. Epidemiology of skin cancer in solid organ transplant recipients" J. Am. Acad. Dermatol. (2011) 10.1016/j.jaad.2010.11.062
[25]
Asgari "Association of Multiple Primary Skin Cancers With Human Immunodeficiency Virus Infection, CD4 Count, and Viral Load" JAMA Dermatol. (2017) 10.1001/jamadermatol.2017.1716
[26]
Howley "Beta genus papillomaviruses and skin cancer" Virology (2015) 10.1016/j.virol.2015.02.004
[27]
Faust "Cutaneous Human Papillomaviruses and Squamous Cell Carcinoma of the Skin: Nested Case-Control Study" Cancer Epidemiol. Biomark. Prev. (2016) 10.1158/1055-9965.epi-15-1290
[28]
Orth "Host defenses against human papillomaviruses: Lessons from epidermodysplasia verruciformis" Curr. Top. Microbiol. Immunol. (2008)
[29]
Ryndock "A risk for non-sexual transmission of human papillomavirus?" Expert Rev. Anti-Infect. Ther. (2014) 10.1586/14787210.2014.959497
[30]
Weinstock "STI Prevalence, Incidence, and Costs in the United States: New Estimates, New Approach" Sex. Transm. Dis. (2021) 10.1097/olq.0000000000001368
[31]
Valasoulis, G., and Pouliakis, A. (2021). The Influence of Sexual Behavior and Demographic Characteristics in the Expression of HPV-Related Biomarkers in a Colposcopy Population of Reproductive Age Greek Women. Biology, 10.
10.3390/biology10080713
[32]
WHO (2010). International Agency for Research on Cancer. IARC Monograohs on the Evaluation of Carcinogenic Risks to Humans. Ingested Nitrate and Nitrite, and Cyanobacterial Peptide Toxins, IARC Publications.
[33]
Bertolotti "Local Management of Anogenital Warts in Non-immunocompromised Adults: A Systematic Review and Meta-analyses of Randomized Controlled Trials" Dermatol. Ther. (2019) 10.1007/s13555-019-00328-z
[34]
Rombaldi "Perinatal transmission of human papilomavirus DNA" Virol. J. (2009) 10.1186/1743-422x-6-83
[35]
Loenenbach "Mucosal and cutaneous Human Papillomavirus seroprevalence among adults in the prevaccine era in Germany—Results from a nationwide population-based survey" Int. J. Infect. Dis. (2019) 10.1016/j.ijid.2019.03.022
[36]
Oliveira "Natural Language Processing for Surveillance of Cervical and Anal Cancer and Precancer: Algorithm Development and Split-Validation Study" JMIR Med. Inform. (2020) 10.2196/20826
[37]
Plummer "Worldwide burden of cancer attributable to HPV by site, country and HPV type" Int. J. Cancer (2017) 10.1002/ijc.30716
[38]
Oh, H.Y., Seo, S.S., Kim, M.K., Lee, D.O., Chung, Y.K., Lim, M.C., Kim, J.Y., Lee, C.W., and Park, S.Y. (2014). Synergistic effect of viral load and alcohol consumption on the risk of persistent high-risk human papillomavirus infection. PLoS ONE, 9.
10.1371/journal.pone.0104374
[39]
Giuliano "Clearance of oncogenic human papillomavirus (HPV) infection: Effect of smoking (United States)" Cancer Causes Control (2002) 10.1023/a:1020668232219
[40]
Wang "Comprehensive analysis of human leukocyte antigen class I alleles and cervical neoplasia in 3 epidemiologic studies" J. Infect. Dis. (2002) 10.1086/342295
[41]
Carreon "Human leukocyte antigen class I and II haplotypes and risk of cervical cancer" Tissue Antigens (2005) 10.1111/j.1399-0039.2005.00478.x
[42]
Chan "HLA-B alleles, high-risk HPV infection and risk for cervical neoplasia in southern Chinese women" Int. J. Cancer (2006) 10.1002/ijc.21528
[43]
Granados "HLA-DRB1 Class II antigen level alleles are associated with persistent HPV infection in Mexican women; a pilot study" Infect. Agents Cancer (2013) 10.1186/1750-9378-8-31
[44]
Chan "Risk association between human leukocyte antigen-A allele and high-risk human papillomavirus infection for cervical neoplasia in Chinese women" J. Infect. Dis. (2005) 10.1086/497342
[45]
Ghaderi "Tumor necrosis factor a-11 and DR15-DQ6 (B*0602) haplotype increase the risk for cervical intraepithelial neoplasia in human papillomavirus 16 seropositive women in Northern Sweden" Cancer Epidemiol. Biomark. Prev. (2000)
[46]
Govan, V.A., Constant, D., Hoffman, M., and Williamson, A.L. (2006). The allelic distribution of -308 Tumor Necrosis Factor-alpha gene polymorphism in South African women with cervical cancer and control women. BMC Cancer, 6.
10.1186/1471-2407-6-24
[47]
Schiller "Understanding and learning from the success of prophylactic human papillomavirus vaccines" Nat. Rev. Microbiol. (2012) 10.1038/nrmicro2872
[48]
IARC Working Group on the Evaluation of Carcinogenic Risks to Humans, World Health Organization, and International Agency for Research on Cancer (2007). Human Papillomaviruses, World Health Organization.
[49]
Wilson "Papillomavirus E1 proteins: Form, function, and features" Virus Genes (2002) 10.1023/a:1015336817836
[50]
Doorbar "The E4 protein; structure, function and patterns of expression" Virology (2013) 10.1016/j.virol.2013.07.008
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Details
- Published
- Dec 07, 2021
- Vol/Issue
- 13(12)
- Pages
- 2455
- License
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Authors
Cite This Article
Carmen Elena Condrat, Lidia Filip, Mirela Gherghe, et al. (2021). Maternal HPV Infection: Effects on Pregnancy Outcome. Viruses, 13(12), 2455. https://doi.org/10.3390/v13122455
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