Cervical Pathologic Findings in Women Infected with Human Papilloma Virus 52

Aim: Human papillomavirus (HPV) type 52 is a high-risk genotype. However, oncogenic potential of HPV 52 remains controversial. This study aimed to evaluate the cervical pathological outcomes associated with HPV 52 infection and to determine whether the risk of high-grade lesions differs between isolated HPV 52 positivity and coinfection with other high risk HPV types.Methods: A retrospective analysis was conducted on 3546 women who underwent colposcopic evaluation. A total of 102 (2.9%) patients with HPV 52 positivity were included. In the study, isolated HPV 52 positivity was defined as the presence of only HPV 52, while combined HPV 52 positivity was defined as the presence of HPV 52 along with other high risk HPV genotypes.Results: In our cohort, 39.2% had isolated HPV 52 infection. High-grade squamous intraepithelial lesions (HSIL) or cancer were detected in 11.8% of women. In addition, with isolated HPV 52 or combined HPV 52 infection didn’t effect final pathological result (p=0.657). One case of stage IB1 cervical squamous cell carcinoma was identified in a patient with isolated HPV 52.Conclusion: The rate of ≥HSIL among HPV 52 positive women was found to be over 10%. Additionally, no significant difference was observed regarding the risk of developing ≥HSIL lesions between patients with isolated HPV 52 and combined HPV 52 infections. Our study underscores the need to include HPV 52 in individualized risk assessment models for cervical cancer screening programme.

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Wilailak, S., M. Kengsakul, and S. Kehoe, Worldwide initiatives to eliminate cervical cancer. International Journal of Gynecology & Obstetrics, 2021. 155: p. 102-106. Crosbie, E.J., et al., Human papillomavirus and cervical cancer. The Lancet, 2013. 382(9895): p. 889-899. 10.1002/ijgo.13879

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Published: Mar 31, 2026
Vol/Issue: 23(1)
Pages: 100-104

Authors

H

Hüseyin Altaş