Adenomatoid Tumor of the Adrenal Gland in Young Woman: From Clinical and Radiological to Pathological Study

Brankica Krstevska; Sasha Jovanovska Mishevska; Rubens Jovanovic

doi:10.4081/rt.2016.6506

journal article Nov 01, 2016

Adenomatoid Tumor of the Adrenal Gland in Young Woman: From Clinical and Radiological to Pathological Study

Brankica Krstevska Sasha Jovanovska Mishevska Rubens Jovanovic

Rare Tumors Vol. 8 No. 4 pp. 185-187 · SAGE Publications

View at Publisher Save 10.4081/rt.2016.6506

Abstract

Adenomatoid tumors are neoplasms of mesothelial origin, usually occurring in the male and female genital tracts. Extragenital localization sites such as adrenal glands are rare but have been reported. When found in the adrenals, they represent great clinical, radiological and pathological diagnostic challenge, with wide range of differential diagnoses to be considered. We present a case of a 30 years old female, with incidental ultrasound finding of unilateral tumor in the right adrenal gland. Multi slices CT scan was of value in localizing this tumor, but not in the precise diagnosis. The tumor ranged from 5.6 cm to 6.4 cm in greatest diameter. Clinical and hormonal examinations excluded Sy. Cushing, M. Conn and pheochromocytoma. The patient underwent laparoscopic right adrenalectomy. A large tumor (d: 8 × 7 × 3 cm) was removed showing no infiltration of the adrenal cortex or medulla, or extra-adrenal extension into the periadrenal adipose tissue. Histological examination showed numerous cystic spaces lined by flattened cubical epithelial cells. The small cystic spaces were separated by edematous fibrovascular stroma with rare epithelial cells with vacuolated cytoplasm. Immunohistochemical staining was positive with vimentin (+), S100 (+), MCA mesothelial Ag (+), CD 68 (+) and negative with acitin (-), CK7 (-), CD3 (-). Adenomatoid tumor is a rare benign neoplasm that should be added in the differential diagnosis of any adrenal tumor occurring in adrenal gland. The histological and immunohistochemical profiles of this adrenal adenomatoid tumor are very supportive in reaching the diagnosis of this benign tumor of a mesothelial cell origin, helping to avoid invasive treatment.

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Details

Published: Nov 01, 2016
Vol/Issue: 8(4)
Pages: 185-187
License: View

Authors

B

Brankica Krstevska

Clinic of Endocrinology, Diabetes and Metabolic Disorders, Medical Faculty, Skopje

S

Sasha Jovanovska Mishevska

Clinic of Endocrinology, Diabetes and Metabolic Disorders, Medical Faculty, Skopje

R

Rubens Jovanovic

Institute of Pathology, Medical Faculty, Skopje, Macedonia

Cite This Article

Brankica Krstevska, Sasha Jovanovska Mishevska, Rubens Jovanovic (2016). Adenomatoid Tumor of the Adrenal Gland in Young Woman: From Clinical and Radiological to Pathological Study. Rare Tumors, 8(4), 185-187. https://doi.org/10.4081/rt.2016.6506

Adenomatoid Tumor of the Adrenal Gland in Young Woman: From Clinical and Radiological to Pathological Study

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