Drug Solubility: Importance and Enhancement Techniques

Ketan T. Savjani; Anuradha K. Gajjar; Jignasa K. Savjani

doi:10.5402/2012/195727

journal article Open Access Jul 05, 2012

Drug Solubility: Importance and Enhancement Techniques

Ketan T. Savjani Anuradha K. Gajjar Jignasa K. Savjani

ISRN Pharmaceutics Vol. 2012 pp. 1-10 · Wiley

View at Publisher Save 10.5402/2012/195727

Abstract

Solubility, the phenomenon of dissolution of solute in solvent to give a homogenous system, is one of the important parameters to achieve desired concentration of drug in systemic circulation for desired (anticipated) pharmacological response. Low aqueous solubility is the major problem encountered with formulation development of new chemical entities as well as for the generic development. More than 40% NCEs (new chemical entities) developed in pharmaceutical industry are practically insoluble in water. Solubility is a major challenge for formulation scientist. Any drug to be absorbed must be present in the form of solution at the site of absorption. Various techniques are used for the enhancement of the solubility of poorly soluble drugs which include physical and chemical modifications of drug and other methods like particle size reduction, crystal engineering, salt formation, solid dispersion, use of surfactant, complexation, and so forth. Selection of solubility improving method depends on drug property, site of absorption, and required dosage form characteristics.

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References

62

[1]

(1986)

[2]

(2000)

[3]

(2007)

[4]

(2011)

[5]

(2002)

[6]

A Theoretical Basis for a Biopharmaceutic Drug Classification: The Correlation of in Vitro Drug Product Dissolution and in Vivo Bioavailability

Gordon L. Amidon, Hans Lennernäs, Vinod P. Shah et al.

Pharmaceutical Research 1995 10.1023/a:1016212804288

[7]

Journal of Bioequivalence & Bioavailability (2010)

[8]

(2008)

[9]

International Journal of Pharmaceutical Sciences Review and Research (2010)

[10]

Research Journal of Pharmacy and Technology (2009)

[11]

Pharmacie Globale (2011)

[12]

10.1016/j.addr.2007.05.011

[13]

10.1016/j.ejpb.2007.05.010

[14]

Methods and Findings in Experimental and Clinical Pharmacology (1998)

[15]

Chemical and Pharmaceutical Bulletin (1961) 10.1248/cpb.9.866

[16]

10.1023/b:pham.0000045226.42859.b8

[17]

10.1016/s0378-5173(01)00941-3

[18]

10.1208/s12249-010-9404-1

[19]

Journal of Pharmaceutical Sciences (1971) 10.1002/jps.2600600902

[20]

10.1007/bf01507758

[21]

(2000)

[22]

(2002)

[23]

Indian Drugs (2005)

[24]

10.1211/0022357023691

[25]

(2000)

[26]

10.1016/s0928-0987(02)00251-8

[27]

10.1016/0378-5173(95)00148-c

[28]

10.1016/j.ejpb.2005.05.009

[29]

10.1081/ddc-52182

[30]

10.1023/a:1014276917363

[31]

10.1016/j.ejpb.2004.03.022

[32]

Drug Delivery Technology (2002)

[33]

10.1016/j.supflu.2006.12.002

[34]

10.1023/a:1020135603052

[35]

10.1016/0378-5173(91)90047-r

[36]

10.1016/s0378-5173(02)00154-0

[37]

AAPS PharmSciTech (2007)

[38]

Chemical Reviews (1998) 10.1021/cr970025p

[39]

Indian Drugs (2005)

[40]

10.1080/03639040500216220

[41]

10.1016/s0731-7085(03)00576-4

[42]

(1993)

[43]

Journal of Pharmacy and Pharmaceutical Sciences (2005)

[44]

AAPS PharmSciTech (2008)

[45]

Journal of Pharmaceutical Sciences (1991) 10.1002/jps.2600800422

[46]

10.1016/0378-5173(82)90143-0

[47]

10.1016/s0927-7757(01)01099-8

[48]

Der Pharmacia Lettre (2010)

[49]

10.1016/j.addr.2007.05.011

[50]

Journal of Pharmaceutical Sciences (1967) 10.1002/jps.2600560712

Showing 50 of 62 references

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Details

Published: Jul 05, 2012
Vol/Issue: 2012
Pages: 1-10
License: View

Authors

K

Ketan T. Savjani

Institute of Pharmacy, Nirma University, Sarkhej Gandhinagar Highway, Gujarat, Ahmedabad 382481, India

A

Anuradha K. Gajjar

Institute of Pharmacy, Nirma University, Sarkhej Gandhinagar Highway, Gujarat, Ahmedabad 382481, India

J

Jignasa K. Savjani

Institute of Pharmacy, Nirma University, Sarkhej Gandhinagar Highway, Gujarat, Ahmedabad 382481, India

Cite This Article

Ketan T. Savjani, Anuradha K. Gajjar, Jignasa K. Savjani (2012). Drug Solubility: Importance and Enhancement Techniques. ISRN Pharmaceutics, 2012, 1-10. https://doi.org/10.5402/2012/195727

Drug Solubility: Importance and Enhancement Techniques

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