Foreign Body Granulomas after the Use of Dermal Fillers: Pathophysiology, Clinical Appearance, Histologic Features, and Treatment

Jeong Min Lee; Yu Jin Kim

doi:10.5999/aps.2015.42.2.232

journal article Open Access Mar 01, 2015

Foreign Body Granulomas after the Use of Dermal Fillers: Pathophysiology, Clinical Appearance, Histologic Features, and Treatment

Jeong Min Lee

Yu Jin Kim

Archives of Plastic Surgery Vol. 42 No. 02 pp. 232-239 · Georg Thieme Verlag KG

View at Publisher Save 10.5999/aps.2015.42.2.232

Abstract

A foreign body granuloma is a non-allergic chronic inflammatory reaction that is mainly composed of multinucleated giant cells. Foreign body granulomas may occur after the administration of any dermal filler. Factors such as the volume of the injection, impurities present in the fillers, and the physical properties of fillers affect granuloma formation. The formation of granulomas involves five phases: protein adsorption, macrophage adhesion, macrophage fusion, and crosstalk. The clinical and pathologic features of granulomas vary depending on the type of filler that causes them. Foreign body granulomas can be treated effectively with intralesional corticosteroid injections. Surgical excisions of granulomas tend to be incomplete because granulomas have ill-defined borders and moreover, surgical excisions may leave scars and deformities.

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References

Details

Published: Mar 01, 2015
Vol/Issue: 42(02)
Pages: 232-239
License: View

Authors

J

Jeong Min Lee

Department of Plastic and Reconstructive Surgery, Gachon University Gil Medical Center, Incheon, Korea

Y

Yu Jin Kim

Department of Plastic and Reconstructive Surgery, Gachon University Gil Medical Center, Incheon, Korea

Cite This Article

Jeong Min Lee, Yu Jin Kim (2015). Foreign Body Granulomas after the Use of Dermal Fillers: Pathophysiology, Clinical Appearance, Histologic Features, and Treatment. Archives of Plastic Surgery, 42(02), 232-239. https://doi.org/10.5999/aps.2015.42.2.232

Foreign Body Granulomas after the Use of Dermal Fillers: Pathophysiology, Clinical Appearance, Histologic Features, and Treatment

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