Exploring the gut-heart axis: A prospective analysis of microbiota in cardiovascular health

Deepika Gnanasekaran; Aadhithya Raaj Pandurangan; Pradeepan Sengiah Ramaswamy; Shrunga Kandhi Raghavendra; Karthick Raman; Gowri Shankar Somasundaram

doi:10.6026/9732063002001900

journal article Dec 31, 2024

Exploring the gut-heart axis: A prospective analysis of microbiota in cardiovascular health

Deepika Gnanasekaran Aadhithya Raaj Pandurangan Pradeepan Sengiah Ramaswamy Shrunga Kandhi Raghavendra Karthick Raman Gowri Shankar Somasundaram

Bioinformation Vol. 20 No. 12 pp. 1900-1903 · Biomedical Informatics

View at Publisher Save 10.6026/9732063002001900

Abstract

The relationship between gut microbiota composition and the development of cardiovascular disease, with a potential role of microbial metabolites in inflammatory and metabolic pathways is of interest. We analyzed gut microbiota and markers of cardiovascular health in a cohort of 100 participants for three years to search for microbial signatures correlated with increased CVD risk. Our results show several correlations between specific microbial taxa, lipid metabolism, and systemic inflammation, whereby a higher Firmicutes/Bacteroides ratio is associated with a greater incidence of CVD. These results suggest that intervention targeting the microbiome has the potential to reduce risk for CVD and point towards a role for gut microbiota in cardiovascular health.

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Details

Published: Dec 31, 2024
Vol/Issue: 20(12)
Pages: 1900-1903

Authors

D

Deepika Gnanasekaran

A

Aadhithya Raaj Pandurangan

P

Pradeepan Sengiah Ramaswamy

S

Shrunga Kandhi Raghavendra

K

Karthick Raman

G

Gowri Shankar Somasundaram

Cite This Article

Deepika Gnanasekaran, Aadhithya Raaj Pandurangan, Pradeepan Sengiah Ramaswamy, et al. (2024). Exploring the gut-heart axis: A prospective analysis of microbiota in cardiovascular health. Bioinformation, 20(12), 1900-1903. https://doi.org/10.6026/9732063002001900

Exploring the gut-heart axis: A prospective analysis of microbiota in cardiovascular health

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