Retrospective cohort study on long-term anticoagulation therapy for bleeding complications among atrial fibrillation patients

Megha Joy; Bethamcherla Bala Chandrudu; Mohamed Thoufeek Hussain Amjat Ibrahim; Richard Fleming; Harish Sidharth Veerachamy

doi:10.6026/973206300213417

journal article Sep 30, 2025

Retrospective cohort study on long-term anticoagulation therapy for bleeding complications among atrial fibrillation patients

Megha Joy Bethamcherla Bala Chandrudu Mohamed Thoufeek Hussain Amjat Ibrahim Richard Fleming Harish Sidharth Veerachamy

Bioinformation Vol. 21 No. 09 pp. 3417-3419 · Biomedical Informatics

View at Publisher Save 10.6026/973206300213417

Abstract

The frequencies and contributing factors to bleeding complications among atrial fibrillation patients on a regimen of long-term oral anticoagulants is of interest. The medical records for 142 patients treated with either warfarin or direct oral anticoagulants (DOACs) were assessed over a period of three years. Major and minor bleeding episodes were associated with instability of the international normalized ratio (INR), the type of anticoagulant medication, and individual patient characteristics. The bleeding complications were observed to occur more frequently with patients presenting with unstable INR values and those treated with warfarin in contrast to DOACs patients. Thus, the importance of a tailored anticoagulation regimen to address bleeding complications in atrial fibrillation is shown.

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Details

Published: Sep 30, 2025
Vol/Issue: 21(09)
Pages: 3417-3419

Authors

M

Megha Joy

B

Bethamcherla Bala Chandrudu

M

Mohamed Thoufeek Hussain Amjat Ibrahim

R

Richard Fleming

H

Harish Sidharth Veerachamy

Cite This Article

Megha Joy, Bethamcherla Bala Chandrudu, Mohamed Thoufeek Hussain Amjat Ibrahim, et al. (2025). Retrospective cohort study on long-term anticoagulation therapy for bleeding complications among atrial fibrillation patients. Bioinformation, 21(09), 3417-3419. https://doi.org/10.6026/973206300213417

Retrospective cohort study on long-term anticoagulation therapy for bleeding complications among atrial fibrillation patients

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