Effect of multiparametric MRI and ultrasound-guided biopsy for early prostate cancer detection: A prospective cohort study

Deepika Karunakaran; Holebasu Ballur; Archana Abarnadevi Karthikeyan; Satya Sudhakara Bhat; Kausalya Perumalsamy; Anannya Vaibhavi

doi:10.6026/973206300214015

journal article Nov 15, 2025

Effect of multiparametric MRI and ultrasound-guided biopsy for early prostate cancer detection: A prospective cohort study

Deepika Karunakaran Holebasu Ballur Archana Abarnadevi Karthikeyan Satya Sudhakara Bhat Kausalya Perumalsamy Anannya Vaibhavi

Bioinformation Vol. 21 No. 11 pp. 4015-4019 · Biomedical Informatics

View at Publisher Save 10.6026/973206300214015

Abstract

It is essential to detect clinically significant prostate cancer (csPCa) in an early and precise manner. However, there are challenges given that the usual TRUS-guided biopsy may leave tumors undiagnosed, or only detect indolent disease. In this prospective cohort study of 200 patients, we compared the diagnostic accuracy of multiparametric MRI (mpMRI) with TRUS-guided biopsy. The study found better sensitivity (91% vs 68%) and specificity (76% vs 60%) than TRUS biopsy, and identified 22% more clinically significant cancers than TRUS biopsies. In addition, mpMRI showed better positive predictive value and negative predictive value than TRUS-guided biopsy; this suggests general advantage in diagnostic accuracy and performance for mpMRI. Data shows, there is support for mpMRI having improved efficacy as a method of detecting clinically significant prostate cancer early compared to TRUS-guided biopsy.

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Published: Nov 15, 2025
Vol/Issue: 21(11)
Pages: 4015-4019

Authors

Archana Abarnadevi Karthikeyan

Cite This Article

Deepika Karunakaran, Holebasu Ballur, Archana Abarnadevi Karthikeyan, et al. (2025). Effect of multiparametric MRI and ultrasound-guided biopsy for early prostate cancer detection: A prospective cohort study. Bioinformation, 21(11), 4015-4019. https://doi.org/10.6026/973206300214015

Effect of multiparametric MRI and ultrasound-guided biopsy for early prostate cancer detection: A prospective cohort study

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