Diagnostic utility of ADA and CBNAAT in tubercular pleural effusion

Patel Ronak Kumar N; Rahul Soni; Darshi Rastogi; Pankaj Kumar Gupta; Sachin Parmar

doi:10.6026/973206300214484

journal article Dec 15, 2025

Diagnostic utility of ADA and CBNAAT in tubercular pleural effusion

Patel Ronak Kumar N Rahul Soni

Darshi Rastogi Pankaj Kumar Gupta

Sachin Parmar

Bioinformation Vol. 21 No. 12 pp. 4484-4487 · Biomedical Informatics

View at Publisher Save 10.6026/973206300214484

Abstract

The diagnostic performance of Adenosine Deaminase (ADA) and Cartridge-Based Nucleic Acid Amplification Test (CBNAAT) in diagnosing tubercular pleural effusion (TPE) is of interest. Hence, a study was conducted over 18 months at LN Medical College and JK Hospital, Bhopal. The study involved 108 adult patients with TPE. Data shows that CBNAAT, although highly specific, had limited sensitivity, while ADA ≥40 IU/L demonstrated strong sensitivity. ADA levels were significantly higher in CBNAAT-positive participants, suggesting that combining both tests enhances diagnostic accuracy. This approach can help reduce the need for invasive procedures and improve timely treatment, especially in resource-limited settings. We show the importance of using ADA and CBNAAT together in the diagnosis of TPE.

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Published: Dec 15, 2025
Vol/Issue: 21(12)
Pages: 4484-4487

Authors

Department of Pulmonary Medicine, All India Institute of Medical Sciences, Gorakhpur, Uttar Pradesh, India

Department of Community Medicine, V.K.S. Government Medical College, Uttar Pradesh, India

Cite This Article

Patel Ronak Kumar N, Rahul Soni, Darshi Rastogi, et al. (2025). Diagnostic utility of ADA and CBNAAT in tubercular pleural effusion. Bioinformation, 21(12), 4484-4487. https://doi.org/10.6026/973206300214484

Diagnostic utility of ADA and CBNAAT in tubercular pleural effusion

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