Wedge resection is equal to segmental resection for pulmonary typical carcinoid patients at localized stage: a population-based analysis

Tao Yan; KAI WANG; Jichang Liu; Yukai Zeng; Fenglong Bie; Guanghui Wang; Jiajun Du

doi:10.7717/peerj.7519

journal article Open Access Sep 10, 2019

Wedge resection is equal to segmental resection for pulmonary typical carcinoid patients at localized stage: a population-based analysis

Tao Yan

KAI WANG

Jichang Liu

Yukai Zeng Fenglong Bie

Guanghui Wang

Jiajun Du

PeerJ Vol. 7 pp. e7519 · PeerJ

View at Publisher Save 10.7717/peerj.7519

Abstract

Background
Medical institutions worldwide have not reached a consensus on what surgery is the most advisable for pulmonary typical carcinoid (TC) patients at the localized stage. This research focuses on exploring whether wedge resection or segmental resection is the superior option.

Methods
The demographic and clinical information of 1,887 TC patients diagnosed at the localized stage from 2004 to 2015 was collected from the Surveillance, Epidemiology, and End Results (SEER) Program. Patient prognosis was evaluated by KM curves. The chi-square test was used to examine the variation between different groups that would be eliminated by propensity score matching (PSM). Univariate and multivariate Cox proportional hazard model analyses were used to evaluate prognostic values of relative factors.

Results
The prognosis of TC was the most favorable for patients suffering from pulmonary squamous cell carcinoma (SCC), adenocarcinoma (ADC), and pulmonary carcinoids (PCs). The choice to have surgery, not the type of surgery chosen, was the most significant independent prognostic factor correlated with overall survival (OS) and lung cancer-special survival (LCSS). The prognostic result of the comparison between wedge resection and segmental resection was not statistically significant before or after PSM. In subgroup analysis, the inference still held.

Topics

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Details

Published: Sep 10, 2019
Vol/Issue: 7
Pages: e7519
License: View

Authors

T

Tao Yan

Institute of Oncology, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, China

K

KAI WANG

Institute of Oncology, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, China; Department of Healthcare Respiratory, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, China

J

Jichang Liu

Institute of Oncology, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, China

Y

Yukai Zeng

Institute of Oncology, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, China

F

Fenglong Bie

Institute of Oncology, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, China

G

Guanghui Wang

Institute of Oncology, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, China; Department of Thoracic Surgery, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, China

J

Jiajun Du

Institute of Oncology, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, China; Department of Thoracic Surgery, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, China

Funding

National Natural Science Foundation Award: 81672288

Natural Science Foundation of Shandong Province of China Award: ZR2019PH002

Cite This Article

Tao Yan, KAI WANG, Jichang Liu, et al. (2019). Wedge resection is equal to segmental resection for pulmonary typical carcinoid patients at localized stage: a population-based analysis. PeerJ, 7, e7519. https://doi.org/10.7717/peerj.7519

Wedge resection is equal to segmental resection for pulmonary typical carcinoid patients at localized stage: a population-based analysis

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