Detection of Salivary Helicobacter pylori in Pediatric Patients and Its Association With Gastrointestinal and Oral Health

Rojin Samani; Mehrzad Sadredinamin; Naghi Dara; Ali Asghar Soleymani; Mojdeh Hakemi-Vala

doi:10.7759/cureus.100744

journal article Jan 04, 2026

Detection of Salivary Helicobacter pylori in Pediatric Patients and Its Association With Gastrointestinal and Oral Health

Rojin Samani Mehrzad Sadredinamin Naghi Dara Ali Asghar Soleymani Mojdeh Hakemi-Vala

Cureus · Springer Science and Business Media LLC

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References

24

[1]

Marshall BJ, Warren JR. Unidentified curved bacilli in the stomach of patients with gastritis and peptic ulceration. Lancet. 1984, 323:1311-5. 10.1016/s0140-6736(84)91816-6 10.1016/s0140-6736(84)91816-6

[2]

Wongsuwanlert M, Teanpaisan R, Pahumunto N, Kaewdech A, Ruangsri P, Sunpaweravong S. Prevalence and virulence factors of Helicobacter pylori isolated from oral cavity of non-disease, gastritis, and gastric cancer patients. J Dent Sci. 2024, 19:1036-43. 10.1016/j.jds.2023.06.024 10.1016/j.jds.2023.06.024

[3]

Katelaris P, Hunt R, Bazzoli F, et al.. Helicobacter pylori World Gastroenterology Organization global guideline. J Clin Gastroenterol. 2023, 57:111-26. 10.1097/MCG.0000000000001719 10.1097/mcg.0000000000001719

[4]

Scholz KJ, Höhne A, Wittmer A, et al.. Co-culture of Helicobacter pylori with oral microorganisms in human saliva. Clin Oral Investig. 2025, 29:79. 10.1007/s00784-025-06160-4 10.1007/s00784-025-06160-4

[5]

Moosazadeh M, Lankarani KB, Afshari M. Meta-analysis of the prevalence of Helicobacter pylori infection among children and adults of Iran. Int J Prev Med. 2016, 7:48. 10.4103/2008-7802.177893 10.4103/2008-7802.177893

[6]

Abdul NS, Khalid Alkhelaiwi A, Awadh Alenazi A, Fehaid Alrashidi R, Ghaleb Salma R. The association of Helicobacter pylori in the oral cavity with dental caries in patients with and without gastric infection: a systematic review. Cureus. 2023, 15:e38398. 10.7759/cureus.38398 10.7759/cureus.38398

[7]

Aksit Bıcak D, Akyuz S, Kıratlı B, et al.. The investigation of Helicobacter pylori in the dental biofilm and saliva samples of children with dyspeptic complaints. BMC Oral Health. 2017, 17:67. 10.1186/s12903-017-0361-x 10.1186/s12903-017-0361-x

[8]

Iwai K, Azuma T, Yonenaga T, et al.. Association between failed eradication of 7-day triple therapy for Helicobacter pylori and untreated dental caries in Japanese adults. Sci Rep. 2024, 14:4043. 10.1038/s41598-024-54757-8 10.1038/s41598-024-54757-8

[9]

Suzuki N, Yoneda M, Naito T, et al.. Detection of Helicobacter pylori DNA in the saliva of patients complaining of halitosis. J Med Microbiol. 2008, 57:1553-9. 10.1099/jmm.0.2008/003715-0 10.1099/jmm.0.2008/003715-0

[10]

Mehdipour A, Chaboki P, Rasouli Asl F, Aghaali M, Sharifinejad N, Shams S. Comparing the prevalence of Helicobacter pylori and virulence factors cagA, vacA, and dupA in supra-gingival dental plaques of children with and without dental caries: a case-control study. BMC Oral Health. 2022, 22:170. 10.1186/s12903-022-02175-5 10.1186/s12903-022-02175-5

[11]

Gruebbel AO. A measurement of dental caries prevalence and treatment service for deciduous teeth. J Dent Res. 1944, 23:163-8. 10.1177/00220345440230030201 10.1177/00220345440230030201

[12]

Le-Tien C, Blemur L, Baltzis D. Artesunate dry emulsion formulation combined with antibiotics for treatment of Helicobacter pylori infections: in vitro/in vivo evaluation. Int J Mol Sci. 2023, 24:110088. 10.3390/ijms241311008 10.3390/ijms241311008

[13]

Falsafi T, Favaedi R, Mahjoub F, Najafi M. Application of stool-PCR test for diagnosis of Helicobacter pylori infection in children. World J Gastroenterol. 2009, 15:484-8. 10.3748/wjg.15.484 10.3748/wjg.15.484

[14]

Goudarzi H, Rezaee H, Rafizadeh M, Taghavi A. Determination of the status of Helicobacter pylori sabA gene in relation to clinical findings. J Med Bacteriol. 2012, 1:3-8.

[15]

El Batawi HY, Venkatachalam T, Francis A, Abujabal R, Shehadat SA. Dental caries-a hiding niche for Helicobacter pylori in children. J Clin Pediatr Dent. 2020, 44:90-4.

[16]

Almashhadany DA, Zefenkey ZF, Zaki AM. Dental risk factors associated with oral Helicobacter pylori infection: a cross-sectional study based on saliva antigen test. J Infect Dev Ctries. 2022, 16:516-21. 10.3855/jidc.15420 10.3855/jidc.15420

[17]

Nasrolahei M, Maleki I, Emadian O. Helicobacter pylori colonization in dental plaque and gastric infection. Rom J Gastroenterol. 2003, 12:293-6.

[18]

Eshraghian A. Epidemiology of Helicobacter pylori infection among the healthy population in Iran and countries of the Eastern Mediterranean Region: a systematic review of prevalence and risk factors. World J Gastroenterol. 2014, 20:17618-25. 10.3748/wjg.v20.i46.17618 10.3748/wjg.v20.i46.17618

[19]

Keikha M, Karbalaei M. Probiotics as the live microscopic fighters against Helicobacter pylori gastric infections. BMC Gastroenterol. 2021, 21:388. 10.1186/s12876-021-01977-1 10.1186/s12876-021-01977-1

[20]

Momtaz H, Souod N, Dabiri H, Sarshar M. Study of Helicobacter pylori genotype status in saliva, dental plaques, stool and gastric biopsy samples. World J Gastroenterol. 2012, 18:2105-11. 10.3748/wjg.v18.i17.2105 10.3748/wjg.v18.i17.2105

[21]

Costa LC, Carvalho MD, Vale FF, Marques AT, Rasmussen LT, Chen T, Barros-Pinheiro M. Helicobacter pylori in oral cavity: current knowledge. Clin Exp Med. 2024, 24:209. 10.1007/s10238-024-01474-1 10.1007/s10238-024-01474-1

[22]

Iwai K, Azuma T, Yonenaga T, et al.. Association between dental caries and Helicobacter pylori infection in Japanese adults: A cross-sectional study. PLoS One. 2022, 17:e0271459. 10.1371/journal.pone.0271459 10.1371/journal.pone.0271459

[23]

Sruthi MA, Mani G, Ramakrishnan M, Selvaraj J. Dental caries as a source of Helicobacter pylori infection in children: an RT-PCR study. Int J Paediatr Dent. 2023, 33:82-8. 10.1111/ipd.13017 10.1111/ipd.13017

[24]

El Khadir M, Alaoui Boukhris S, Benajah DA, et al.. Detection of Helicobacter pylori urease antigen in saliva in patients with different gastric H. pylori status. J Chin Med Assoc. 2016, 79:363-7. 10.1016/j.jcma.2016.01.017 10.1016/j.jcma.2016.01.017

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Published: Jan 04, 2026

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Rojin Samani, Mehrzad Sadredinamin, Naghi Dara, et al. (2026). Detection of Salivary Helicobacter pylori in Pediatric Patients and Its Association With Gastrointestinal and Oral Health. Cureus. https://doi.org/10.7759/cureus.100744

Detection of Salivary Helicobacter pylori in Pediatric Patients and Its Association With Gastrointestinal and Oral Health

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