Human Leukocyte Antigen Alleles Compatibility and Immunophenotypic Profile Associations in Infertile Couples

Georgia Oikonomou; Nikolaos Vlachadis; Vassilios Tsamadias; Irene Lambrinoudaki; Efthymios Deligeoroglou; Nikolaos F Vlahos; Emmanuel Economou

doi:10.7759/cureus.36584

journal article Mar 23, 2023

Human Leukocyte Antigen Alleles Compatibility and Immunophenotypic Profile Associations in Infertile Couples

Georgia Oikonomou Nikolaos Vlachadis Vassilios Tsamadias Irene Lambrinoudaki

Efthymios Deligeoroglou Nikolaos F Vlahos Emmanuel Economou

Cureus · Springer Science and Business Media LLC

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References

27

[1]

Evaluation and treatment of recurrent pregnancy loss. a committee opinion. Fertil Steril. 2012, 98:1103-11. 10.1016/j.fertnstert.2012.06.048 10.1016/j.fertnstert.2012.06.048

[2]

Branch DW, Gibson M, Silver RM. Clinical practice. Recurrent miscarriage. N Engl J Med. 2010, 363:1740-7. 10.1056/NEJMcp1005330 10.1056/nejmcp1005330

[3]

Larsen EC, Christiansen OB, Kolte AM, Macklon N. New insights into mechanisms behind miscarriage. BMC Med. 2013, 11:154. 10.1186/1741-7015-11-154 10.1186/1741-7015-11-154

[4]

Garneau AS, Young SL. Defining recurrent implantation failure: a profusion of confusion or simply an illusion?. Fertil Steril. 2021, 116:1432-5. 10.1016/j.fertnstert.2021.10.023 10.1016/j.fertnstert.2021.10.023

[5]

Vlachadis N, Vrachnis N, Economou E, Siristatidis C. Zooming in on the definition of 'recurrent implantation failure'. Reprod Biomed Online. 2014, 29:144-5. 10.1016/j.rbmo.2014.03.003 10.1016/j.rbmo.2014.03.003

[6]

Crux NB, Elahi S. Human leukocyte antigen (HLA) and immune regulation: how do classical and non-classical HLA alleles modulate immune response to human immunodeficiency virus and hepatitis C virus infections?. Front Immunol. 2017, 8:832. 10.3389/fimmu.2017.00832 10.3389/fimmu.2017.00832

[7]

Meuleman T, Lashley LE, Dekkers OM, van Lith JM, Claas FH, Bloemenkamp KW. HLA associations and HLA sharing in recurrent miscarriage: A systematic review and meta-analysis. Hum Immunol. 2015, 76:362-73. 10.1016/j.humimm.2015.02.004 10.1016/j.humimm.2015.02.004

[8]

Mosaferi E, Alizadeh Gharamaleki N, Farzadi L, et al.. The study of HLA-G gene and protein expression in patients with recurrent miscarriage. Adv Pharm Bull. 2019, 9:70-5. 10.15171/apb.2019.009 10.15171/apb.2019.009

[9]

Grimstad F, Krieg S. Immunogenetic contributions to recurrent pregnancy loss. J Assist Reprod Genet. 2016, 33:833-47. 10.1007/s10815-016-0720-6 10.1007/s10815-016-0720-6

[10]

Seshadri S, Sunkara SK. Natural killer cells in female infertility and recurrent miscarriage: a systematic review and meta-analysis. Hum Reprod Update. 2014, 20:429-38. 10.1093/humupd/dmt056 10.1093/humupd/dmt056

[11]

Monin L, Whettlock EM, Male V. Immune responses in the human female reproductive tract. Immunology. 2020, 160:106-15. 10.1111/imm.13136 10.1111/imm.13136

[12]

Niehrs A, Altfeld M. Regulation of NK-Cell function by HLA class II. Front Cell Infect Microbiol. 2020, 10:55. 10.3389/fcimb.2020.00055 10.3389/fcimb.2020.00055

[13]

Guerrero B, Hassouneh F, Delgado E, Casado JG, Tarazona R. Natural killer cells in recurrent miscarriage: An overview. J Reprod Immunol. 2020, 142:103209. 10.1016/j.jri.2020.103209 10.1016/j.jri.2020.103209

[14]

Skapenko A, Leipe J, Lipsky PE, Schulze-Koops H. The role of the T cell in autoimmune inflammation. Arthritis Res Ther. 2005, 7 Suppl 2:S4-14. 10.1186/ar1703 10.1186/ar1703

[15]

Guerin LR, Prins JR, Robertson SA. Regulatory T-cells and immune tolerance in pregnancy: a new target for infertility treatment?. Hum Reprod Update. 2009, 15:517-35. 10.1093/humupd/dmp004 10.1093/humupd/dmp004

[16]

Jin LP, Chen QY, Zhang T, Guo PF, Li DJ. The CD4+CD25 bright regulatory T cells and CTLA-4 expression in peripheral and decidual lymphocytes are down-regulated in human miscarriage. Clin Immunol. 2009, 133:402-10. 10.1016/j.clim.2009.08.009 10.1016/j.clim.2009.08.009

[17]

U S, A P, P G, D P, V S, K G. HLA allele associations in idiopathic recurrent spontaneous abortion patients from India. J Hum Reprod Sci. 2008, 1:19-24. 10.4103/0974-1208.39592 10.4103/0974-1208.39592

[18]

Creus M, Balasch J, Fábregues F, et al.. Parental human leukocyte antigens and implantation failure after in-vitro fertilization. Hum Reprod. 1998, 13:39-43. 10.1093/humrep/13.1.39 10.1093/humrep/13.1.39

[19]

Nowak JK, Glapa-Nowak A, Banaszkiewicz A, et al.. HLA-DQA1*05 associates with extensive ulcerative colitis at diagnosis: an observational study in children. Genes (Basel). 2021, 12:10.3390/genes12121934 10.3390/genes12121934

[20]

Kruse C, Steffensen R, Varming K, Christiansen OB. A study of HLA-DR and -DQ alleles in 588 patients and 562 controls confirms that HLA-DRB1*03 is associated with recurrent miscarriage. Hum Reprod. 2004, 19:1215-21. 10.1093/humrep/deh200 10.1093/humrep/deh200

[21]

Aruna M, Nagaraja T, Andal Bhaskar S, et al.. Novel alleles of HLA-DQ and -DR loci show association with recurrent miscarriages among South Indian women. Hum Reprod. 2011, 26:765-74. 10.1093/humrep/der024 10.1093/humrep/der024

[22]

Triggianese P, Perricone C, De Martino E, et al.. Human leukocyte antigen (HLA) typing study identifies maternal DQ2 susceptibility alleles among infertile women: potential associations with autoimmunity and micronutrients. Nutrients. 2021, 13:10.3390/nu13093270 10.3390/nu13093270

[23]

Vlachadis N, Tsamadias V, Kouskouni E, Vitoratos N, Hatziveis K, Economou E. Genetic heterogeneity of platelet glycoproteins Ia and IIIa is associated with in vitro fertilisation implantation failure. J Obstet Gynaecol. 2015, 35:733-6. 10.3109/01443615.2015.1004528 10.3109/01443615.2015.1004528

[24]

Vlachadis N, Tsamadias V, Vrachnis N, Kaparos G, Vitoratos N, Kouskouni E, Economou E. Genetic heterogeneity of platelet glycoproteins Ia and IIIa and the risk of spontaneous miscarriages. J Matern Fetal Neonatal Med. 2017, 30:1309-13. 10.1080/14767058.2016.1212330 10.1080/14767058.2016.1212330

[25]

Vlachadis N, Tsamadias V, Vrachnis N, Kaparos G, Vitoratos N, Kouskouni E, Economou E. Associations of combined polymorphisms of the platelet membrane glycoproteins Ia and IIIa and the platelet-endothelial cell adhesion molecule-1 and P-Selectin genes with IVF implantation failures. J Obstet Gynaecol. 2017, 37:363-9. 10.1080/01443615.2016.1256978 10.1080/01443615.2016.1256978

[26]

Vlachadis N, Tsamadias V, Siori M, Vrachnis N, Economou E. Association of the PECAM-1 (Leu125Val) and P-Selectin (Thr715Pro) gene polymorphisms with unexplained spontaneous miscarriages. Cureus. 2022, 14:e21859. 10.7759/cureus.21859 10.7759/cureus.21859

[27]

Franasiak JM, Scott RT. Contribution of immunology to implantation failure of euploid embryos. Fertil Steril. 2017, 107:1279-83. 10.1016/j.fertnstert.2017.04.019 10.1016/j.fertnstert.2017.04.019

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Published: Mar 23, 2023

Authors

Department of Obstetrics and Gynecology, University of Athens, Aretaieio Hospital, Athens, Greece,

E

Efthymios Deligeoroglou

Cite This Article

Georgia Oikonomou, Nikolaos Vlachadis, Vassilios Tsamadias, et al. (2023). Human Leukocyte Antigen Alleles Compatibility and Immunophenotypic Profile Associations in Infertile Couples. Cureus. https://doi.org/10.7759/cureus.36584

Human Leukocyte Antigen Alleles Compatibility and Immunophenotypic Profile Associations in Infertile Couples

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