An Investigation Into the Hepatoprotective Properties of Berberis asiatica, Withania somnifera, and Their Combination in Streptozotocin-Nicotinamide-Induced Type II Diabetes Mellitus in Wistar Rats

Devkumar D Tiwari; Vandana M Thorat; Prathamesh V Pakale

doi:10.7759/cureus.78690

journal article Feb 07, 2025

An Investigation Into the Hepatoprotective Properties of Berberis asiatica, Withania somnifera, and Their Combination in Streptozotocin-Nicotinamide-Induced Type II Diabetes Mellitus in Wistar Rats

Devkumar D Tiwari Vandana M Thorat Prathamesh V Pakale

Cureus · Springer Science and Business Media LLC

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References

25

[1]

Diabetes. (2025). Accessed. January 10, 2025: https://www.who.int/news-room/fact-sheets/detail/diabetes.

[2]

Reed J, Bain S, Kanamarlapudi V. A review of current trends with type 2 diabetes epidemiology, aetiology, pathogenesis, treatments and future perspectives. Diabetes Metab Syndr Obes. 2021, 14:3567-602. 10.2147/DMSO.S319895 10.2147/dmso.s319895

[3]

Mohamed J, Nazratun Nafizah AH, Zariyantey AH, Budin SB. Mechanisms of diabetes-induced liver damage: the role of oxidative stress and inflammation. Sultan Qaboos Univ Med J. 2016, 16:e132-41. 10.18295/squmj.2016.16.02.002

[4]

Samsu N. Diabetic nephropathy: challenges in pathogenesis, diagnosis, and treatment. Biomed Res Int. 2021, 2021:1497449. 10.1155/2021/1497449 10.1155/2021/1497449

[5]

Type 2 diabetes and your liver. (2024). Accessed. January 10, 2025: https://www.cdc.gov/diabetes/diabetes-complications/type-2-diabetes-liver-disease.html.

[6]

Mooli RG, Mukhi D, Ramakrishnan SK. Oxidative stress and redox signaling in the pathophysiology of liver diseases. Compr Physiol. 2022, 12:3167-92. 10.1002/cphy.c200021 10.1002/cphy.c200021

[7]

Kuttiappan A, Chenchula S, Vanangamudi M, Bhatt S, Chikatipalli R, Shaila Bhanu P, Bandaru N. Hepatoprotective effect of flavonoid rich fraction of Sesbania grandiflora: results of in vivo, in vitro, and molecular docking studies. J Ayurveda Integr Med. 2024, 15:101036. 10.1016/j.jaim.2024.101036 10.1016/j.jaim.2024.101036

[8]

Tiwari DD, Thorat VM, Pakale PV, Patil SJ. Study of antidiabetic properties of Berberis asiatica and Withania somnifera in streptozotocin-nicotinamide-induced type II diabetes mellitus in Wistar rats. Cureus. 2024, 16:e64379. 10.7759/cureus.64379 10.7759/cureus.64379

[9]

Motyl K, McCabe LR. Streptozotocin, type I diabetes severity and bone. Biol Proced Online. 2009, 11:296-315. 10.1007/s12575-009-9000-5 10.1007/s12575-009-9000-5

[10]

Rakieten N, Rakieten ML, Nadkarni MV. Studies on the diabetogenic action of streptozotocin. Cancer Chemother Rep. 1963, 29:91-8.

[11]

Nahdi AM, John A, Raza H. Elucidation of molecular mechanisms of streptozotocin-induced oxidative stress, apoptosis, and mitochondrial dysfunction in Rin-5F pancreatic β-cells. Oxid Med Cell Longev. 2017, 2017:7054272. 10.1155/2017/7054272 10.1155/2017/7054272

[12]

Masiello P, Broca C, Gross R, et al.. Experimental NIDDM: development of a new model in adult rats administered streptozotocin and nicotinamide. Diabetes. 1998, 47:224-9. 10.2337/diab.47.2.224 10.2337/diab.47.2.224

[13]

In Brief. How Does the Liver Work?. Institute for Quality and Efficiency in Health Care, Cologne, Germany; 2006.

[14]

Pandey B, Baral R, Kaundinnyayana A, Panta S. Promising hepatoprotective agents from the natural sources: a study of scientific evidence. Egypt Liver J. 2023, 14:13.

[15]

Oliveira-Costa JF, Meira CS, Neves MV, Dos Reis BP, Soares MB. Anti-inflammatory activities of betulinic acid: a review. Front Pharmacol. 2022, 13:883857. 10.3389/fphar.2022.883857 10.3389/fphar.2022.883857

[16]

Singh N, Bhalla M, de Jager P, Gilca M. An overview on ashwagandha: a Rasayana (rejuvenator) of Ayurveda. Afr J Tradit Complement Altern Med. 2011, 8:208-13. 10.4314/ajtcam.v8i5S.9 10.4314/ajtcam.v8i5s.9

[17]

Leena MM, Silvia MG, Vinitha K, Moses JA, Anandharamakrishnan C. Synergistic potential of nutraceuticals: mechanisms and prospects for futuristic medicine. Food Funct. 2020, 11:9317-37. 10.1039/d0fo02041a

[18]

Zuo F, Nakamura N, Akao T, Hattori M. Pharmacokinetics of berberine and its main metabolites in conventional and pseudo germ-free rats determined by liquid chromatography/ion trap mass spectrometry. Drug Metab Dispos. 2006, 34:2064-72. 10.1124/dmd.106.011361 10.1124/dmd.106.011361

[19]

Tiwari BK, Khosa RL. Evaluation of the hepatoprotective and antioxidant effect of Berberis asiatica against experimentally induced liver injury in rats. Int J Pharm Pharm Sci. 2010, 2:92-7.

[20]

Jahan F, Sultan SA, Islam MH. Berberis aristata and its secondary metabolites: insights into nutraceutical and therapeutical applications. Mod Chin Med. 2022, 5:100184-2667. 10.1016/j.prmcm.2022.100184 10.1016/j.prmcm.2022.100184

[21]

Gupta GL, Rana AC. Withania somnifera (ashwagandha): a review. Pharmacogn Rev. 2007, 1:129-36.

[22]

Mishra LC, Singh BB, Dagenais S. Scientific basis for the therapeutic use of Withania somnifera (ashwagandha): a review. Altern Med Rev. 2000, 5:334-46.

[23]

Grădinariu L, Dediu L, Crețu M, et al.. The antioxidant and hepatoprotective potential of berberine and silymarin on acetaminophen induced toxicity in Cyprinus carpio L. Animals (Basel). 2024, 14:373. 10.3390/ani14030373 10.3390/ani14030373

[24]

Kuo CL, Chi CW, Liu TY. The anti-inflammatory potential of berberine in vitro and in vivo. Cancer Lett. 2004, 203:127-37. 10.1016/j.canlet.2003.09.002 10.1016/j.canlet.2003.09.002

[25]

Bhattacharya SK, Muruganandam AV. Adaptogenic activity of Withania somnifera: an experimental study using a rat model of chronic stress. Pharmacol Biochem Behav. 2003, 75:547-55. 10.1016/S0091-3057(03)00110-2 10.1016/s0091-3057(03)00110-2

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Published: Feb 07, 2025

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Devkumar D Tiwari, Vandana M Thorat, Prathamesh V Pakale (2025). An Investigation Into the Hepatoprotective Properties of Berberis asiatica, Withania somnifera, and Their Combination in Streptozotocin-Nicotinamide-Induced Type II Diabetes Mellitus in Wistar Rats. Cureus. https://doi.org/10.7759/cureus.78690

An Investigation Into the Hepatoprotective Properties of Berberis asiatica, Withania somnifera, and Their Combination in Streptozotocin-Nicotinamide-Induced Type II Diabetes Mellitus in Wistar Rats

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