journal article Nov 16, 2025

The Impact of Probiotics on Acne Vulgaris: A Meta-Analysis of Randomized Controlled Trials

View at Publisher Save 10.7759/cureus.97010
Topics

No keywords indexed for this article. Browse by subject →

References
26
[1]
Williams HC, Dellavalle RP, Garner S. Acne vulgaris. Lancet. 2012, 379:361-72. 10.1016/S0140-6736(11)60321-8 10.1016/s0140-6736(11)60321-8
[2]
Vasam M, Korutla S, Bohara RA. Acne vulgaris: A review of the pathophysiology, treatment, and recent nanotechnology based advances. Biochem Biophys Rep. 2023, 36:101578. 10.1016/j.bbrep.2023.101578 10.1016/j.bbrep.2023.101578
[3]
Heng AH, Chew FT. Systematic review of the epidemiology of acne vulgaris. Sci Rep. 2020, 10:5754. 10.1038/s41598-020-62715-3 10.1038/s41598-020-62715-3
[4]
Leung AK, Barankin B, Lam JM, Leong KF, Hon KL. Dermatology: How to manage acne vulgaris. Drugs Context. 2021, 10:2021-8-6. 10.7573/dic.2021-8-6 10.7573/dic.2021-8-6
[5]
Bowe WP, Logan AC. Acne vulgaris, probiotics and the gut-brain-skin axis - Back to the future?. Gut Pathog. 2011, 3:1. 10.1186/1757-4749-3-1 10.1186/1757-4749-3-1
[6]
Muizzuddin N, Maher W, Sullivan M, Schnittger S, Mammone T. Physiological effect of a probiotic on skin. J Cosmet Sci. 2012, 63:385-95.
[7]
Marson JW, Baldwin HE. New concepts, concerns, and creations in acne. Dermatol Clin. 2019, 37:1-9. 10.1016/j.det.2018.07.002 10.1016/j.det.2018.07.002
[8]
Lee YB, Byun EJ, Kim HS. Potential role of the microbiome in acne: A comprehensive review. J Clin Med. 2019, 8:987. 10.3390/jcm8070987 10.3390/jcm8070987
[9]
Latif A, Shehzad A, Niazi S, et al.. Probiotics: Mechanism of action, health benefits and their application in food industries. Front Microbiol. 2023, 14:1216674. 10.3389/fmicb.2023.1216674 10.3389/fmicb.2023.1216674
[10]
Trivedi MK, Bosanac SS, Sivamani RK, Larsen LN. Emerging therapies for acne vulgaris. Am J Clin Dermatol. 2018, 19:505-16. 10.1007/s40257-018-0345-x 10.1007/s40257-018-0345-x
[11]
Kumar S, Mahajan BB, Kamra N. Future perspective of probiotics in dermatology: An old wine in new bottle. Dermatol Online J. 2014, 20:13030/qt8br333fc. 10.5070/d3209023918
[12]
Sutema I, Latarissa IR, Widowati I, Sartika CR, Ciptasari NWE, Lestari K. Efficacy of probiotic supplements and topical applications in the treatment of acne: A scoping review of current results. J Exp Pharmacol. 2025, 17:1-14. 10.2147/jep.s498769 10.2147/jep.s498769
[13]
Shields A, Ly S, Wafae B, et al.. Safety and effectiveness of oral nutraceuticals for treating acne: A systematic review. JAMA Dermatol. 2023, 159:1373-82. 10.1001/jamadermatol.2023.3949 10.1001/jamadermatol.2023.3949
[14]
Talebi S, Shab-Bidar S, Mohammadi H, Moini A, Djafarian K. The effects of intermittent fasting diet alone or in combination with probiotic supplementation in comparison with calorie-restricted diet on metabolic and hormonal profile in patients with polycystic ovary syndrome: Study protocol for a randomized clinical trial. Trials. 2023, 24:690. 10.1186/s13063-023-07691-5 10.1186/s13063-023-07691-5
[15]
McLoughlin IJ, Wright EM, Tagg JR, Jain R, Hale JD. Skin microbiome-The next frontier for probiotic intervention. Probiotics Antimicrob Proteins. 2022, 14:630-47. 10.1007/s12602-021-09824-1 10.1007/s12602-021-09824-1
[16]
Paetzold B, Willis JR, Pereira de Lima J, et al.. Skin microbiome modulation induced by probiotic solutions. Microbiome. 2019, 7:95. 10.1186/s40168-019-0709-3 10.1186/s40168-019-0709-3
[17]
Baquerizo Nole KL, Yim E, Keri JE. Probiotics and prebiotics in dermatology. J Am Acad Dermatol. 2014, 71:814-21. 10.1016/j.jaad.2014.04.050 10.1016/j.jaad.2014.04.050
[18]
Roudsari MR, Karimi R, Sohrabvandi S, Mortazavian AM. Health effects of probiotics on the skin. Crit Rev Food Sci Nutr. 2015, 55:1219-40. 10.1080/10408398.2012.680078 10.1080/10408398.2012.680078
[19]
Kang BS, Seo JG, Lee GS, et al.. Antimicrobial activity of enterocins from Enterococcus faecalis SL-5 against Propionibacterium acnes, the causative agent in acne vulgaris, and its therapeutic effect. J Microbiol. 2009, 47:101-9. 10.1007/s12275-008-0179-y 10.1007/s12275-008-0179-y
[20]
Rinaldi F, Marotta L, Mascolo A, Amoruso A, Pane M, Giuliani G, Pinto D. Facial acne: A randomized, double-blind, placebo-controlled study on the clinical efficacy of a symbiotic dietary supplement. Dermatol Ther (Heidelb). 2022, 12:577-89. 10.1007/s13555-021-00664-z 10.1007/s13555-021-00664-z
[21]
Eguren C, Navarro-Blasco A, Corral-Forteza M, et al.. A randomized clinical trial to evaluate the efficacy of an oral probiotic in acne vulgaris. Acta Derm Venereol. 2024, 104:adv33206. 10.2340/actadv.v104.33206 10.2340/actadv.v104.33206
[22]
Kim MJ, Kim KP, Choi E, et al.. Effects of Lactobacillus plantarum CJLP55 on clinical improvement, skin condition and urine bacterial extracellular vesicles in patients with acne vulgaris: A randomized, double-blind, placebo-controlled study. Nutrients. 2021, 13:1368. 10.3390/nu13041368 10.3390/nu13041368
[23]
Talebi S, Shab-Bidar S, Moini A, Mohammadi H, Djafarian K. The effects of time-restricted eating alone or in combination with probiotic supplementation in comparison with a calorie-restricted diet on endocrine and metabolic profiles in women with polycystic ovary syndrome: A randomized clinical trial. Diabetes Obes Metab. 2024, 26:4468-79. 10.1111/dom.15801 10.1111/dom.15801
[24]
Xu W, Xu J, Huang D, Wang C, Song J, Chen X, Suo H. Acne vulgaris: Advances in pathogenesis and prevention strategies. Eur J Clin Microbiol Infect Dis. 2025, 44:515-32. 10.1007/s10096-024-04984-8 10.1007/s10096-024-04984-8
[25]
Bowe WP. Probiotics in acne and rosacea. Cutis. 2013, 92:6-7.
[26]
Fuchs-Tarlovsky V, Marquez-Barba MF, Sriram K. Probiotics in dermatologic practice. Nutrition. 2016, 32:289-95. 10.1016/j.nut.2015.09.001 10.1016/j.nut.2015.09.001
Metrics
1
Citations
26
References
Details
Published
Nov 16, 2025
Cite This Article
Marwa Mohamed, Ahsan Ullah, Rosi Hassan, et al. (2025). The Impact of Probiotics on Acne Vulgaris: A Meta-Analysis of Randomized Controlled Trials. Cureus. https://doi.org/10.7759/cureus.97010
Related

You May Also Like

Artificial Hallucinations in ChatGPT: Implications in Scientific Writing

Hussam Alkaissi, Samy I McFarlane · 2023

803 citations

Role of Physical Activity on Mental Health and Well-Being: A Review

Aditya Mahindru, Pradeep Patil · 2023

311 citations

Epidemiology of Glaucoma: The Past, Present, and Predictions for the Future

Karen Allison, Deepkumar Patel · 2020

256 citations

Obesity: A Chronic Low-Grade Inflammation and Its Markers

Deepesh Khanna, Siya Khanna · 2022

195 citations