Researcher Profile

Malkit Sami

🏛 Immunocore Ltd. Abingdon UK

Publications

567

Citations

Co-Authors

Active Years

Publications

Open Access Journal Article European Journal of Immunology May 27, 2019

TCR‐induced alteration of primary MHC peptide anchor residue

Florian Madura · Pierre J. Rizkallah · Mateusz Legut · Christopher J. Holland +15 more

10.1002/eji.201948085 27 citations

Open Access Journal Article Scientific Reports Jan 13, 2016

Direct molecular mimicry enables off-target cardiovascular toxicity by an enhanced affinity TCR designed for cancer immunotherapy

Marine C C Raman · Pierre J Rizkallah · Ruth Simmons · Zoe Donnellan +12 more

10.1038/srep18851 101 citations

Open Access Journal Article Journal of Biological Chemistry Jun 01, 2013

T-cell Receptor Specificity Maintained by Altered Thermodynamics

Florian Madura · Pierre J. Rizkallah · Kim M. Miles · Christopher J. Holland +12 more

10.1074/jbc.m113.464560 36 citations

Journal Article Protein Engineering, Design and Selection Jul 20, 2007

Crystal structures of high affinity human T-cell receptors bound to peptide major histocompatibility complex reveal native diagonal binding geometry

Malkit Sami · Pierre J. Rizkallah · Steve Dunn · Peter Molloy +8 more

10.1093/protein/gzm033 55 citations

Journal Article Protein Science Apr 01, 2006

Directed evolution of human T cell receptor CDR2 residues by phage display dramatically enhances affinity for cognate peptide‐MHC without increasing apparent cross‐reactivity

STEVEN M. DUNN · Pierre J. Rizkallah · Emma Baston · Tara Mahon +7 more

10.1110/ps.051936406 103 citations

Journal Article The Journal of Experimental Medicine Apr 18, 2005

Structural and kinetic basis for heightened immunogenicity of T cell vaccines

Ji-Li Chen · Guillaume Stewart-Jones · Giovanna Bossi · Nikolai M. Lissin +15 more

10.1084/jem.20042323 245 citations

Publication Timeline

2019

2016

2013

2007

2006

2005

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