Researcher Profile

Keith R. Hornberger

🏛 Arvinas Operations, Inc., 5 Science Park, 395 Winchester Avenue, New Haven, Connecticut 06511 United States

0000-0002-6127-2814

Publications

909

Citations

Co-Authors

Active Years

Publications

Journal Article Cancer Research Apr 03, 2026

Abstract 4309: Preclinical antitumor and immunomodulatory activity of ARV-6723, a PROTAC hematopoietic progenitor kinase 1 (HPK1) degrader, versus immune checkpoint inhibitors (ICIs)

Anna C. Van Acker · William Corwin · Albert DeBerardinis · Emma Rousseau +13 more

10.1158/1538-7445.am2026-4309

Open Access Journal Article Journal of Medicinal Chemistry Jun 06, 2023

Physicochemical Property Determinants of Oral Absorption for PROTAC Protein Degraders

Keith R. Hornberger · Erika M. V. Araujo

10.1021/acs.jmedchem.3c00740 126 citations

Journal Article Nature Reviews Clinical Oncology Feb 13, 2023

Protein degraders enter the clinic — a new approach to cancer therapy

Deborah Chirnomas · Keith R. Hornberger · Craig M. Crews

10.1038/s41571-023-00736-3 546 citations

Journal Article ACS Medicinal Chemistry Letters Feb 18, 2013

Discovery of Dabrafenib: A Selective Inhibitor of Raf Kinases with Antitumor Activity against B-Raf-Driven Tumors

Tara R. Rheault · John C. Stellwagen · George M. Adjabeng · Keith R. Hornberger +14 more

10.1021/ml4000063 237 citations

Publication Timeline

2026

2023

2013

Frequent Co-Authors

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Ignacio J. Juncadella

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Scott H. Dickerson

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