Limited life cycle and cost assessment for the bioconversion of lignin‐derived aromatics into adipic acid

Jozef B. J. H. van Duuren; Paul J. de Wild; Sören Starck; Christian Bradtmöller; Mirjam Selzer; Kerstin Mehlmann; Roland Schneider; Michael Kohlstedt; Ignacio Poblete‐Castro; Jessica Stolzenberger; Nadja Barton; Michel Fritz; Stephan Scholl; Joachim Venus; Christoph Wittmann

doi:10.1002/bit.27299

journal article Open Access Feb 20, 2020

Limited life cycle and cost assessment for the bioconversion of lignin‐derived aromatics into adipic acid

Paul J. de Wild Sören Starck Christian Bradtmöller Mirjam Selzer Kerstin Mehlmann Roland Schneider Michael Kohlstedt Ignacio Poblete‐Castro Jessica Stolzenberger Nadja Barton Michel Fritz Stephan Scholl Joachim Venus

Christoph Wittmann

Biotechnology and Bioengineering Vol. 117 No. 5 pp. 1381-1393 · Wiley

View at Publisher Save 10.1002/bit.27299

Abstract

AbstractLignin is an abundant and heterogeneous waste byproduct of the cellulosic industry, which has the potential of being transformed into valuable biochemicals via microbial fermentation. In this study, we applied a fast‐pyrolysis process using softwood lignin resulting in a two‐phase bio‐oil containing monomeric and oligomeric aromatics without syringol. We demonstrated that an additional hydrodeoxygenation step within the process leads to an enhanced thermochemical conversion of guaiacol into catechol and phenol. After steam bath distillation, Pseudomonas putida KT2440‐BN6 achieved a percent yield of cis, cis‐muconic acid of up to 95 mol% from catechol derived from the aqueous phase. We next established a downstream process for purifying cis, cis‐muconic acid (39.9 g/L) produced in a 42.5 L fermenter using glucose and benzoate as carbon substrates. On the basis of the obtained values for each unit operation of the empirical processes, we next performed a limited life cycle and cost analysis of an integrated biotechnological and chemical process for producing adipic acid and then compared it with the conventional petrochemical route. The simulated scenarios estimate that by attaining a mixture of catechol, phenol, cresol, and guaiacol (1:0.34:0.18:0, mol ratio), a titer of 62.5 (g/L) cis, cis‐muconic acid in the bioreactor, and a controlled cooling of pyrolysis gases to concentrate monomeric aromatics in the aqueous phase, the bio‐based route results in a reduction of CO2‐eq emission by 58% and energy demand by 23% with a contribution margin for the aqueous phase of up to 88.05 euro/ton. We conclude that the bio‐based production of adipic acid from softwood lignins brings environmental benefits over the petrochemical procedure and is cost‐effective at an industrial scale. Further research is essential to achieve the proposed cis, cis‐muconic acid yield from true lignin‐derived aromatics using whole‐cell biocatalysts.

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Details

Published: Feb 20, 2020
Vol/Issue: 117(5)
Pages: 1381-1393
License: View

Authors

J

Jozef B. J. H. van Duuren

Institute of Systems Biotechnology Saarland University Saarbrücken Germany

P

Paul J. de Wild

Biomass & Energy Efficiency, TNO Petten The Netherlands

S

Sören Starck

Institute of Systems Biotechnology Saarland University Saarbrücken Germany

C

Christian Bradtmöller

Institute for Chemical and Thermal Process Engineering Technische Universität Braunschweig Braunschweig Germany

M

Mirjam Selzer

Institute of Systems Biotechnology Saarland University Saarbrücken Germany

K

Kerstin Mehlmann

Department of Bioengineering Leibniz Institute for Agricultural Engineering and Bioeconomy (ATB) Potsdam Germany

R

Roland Schneider

Department of Bioengineering Leibniz Institute for Agricultural Engineering and Bioeconomy (ATB) Potsdam Germany

M

Michael Kohlstedt

Institute of Systems Biotechnology Saarland University Saarbrücken Germany

I

Ignacio Poblete‐Castro

Biosystems Engineering Laboratory, Center for Bioinformatics and Integrative Biology, Faculty of Natural Sciences Universidad Andres Bello Santiago de Chile Chile

J

Jessica Stolzenberger

Institute of Systems Biotechnology Saarland University Saarbrücken Germany

N

Nadja Barton

Institute of Systems Biotechnology Saarland University Saarbrücken Germany

M

Michel Fritz

Institute of Systems Biotechnology Saarland University Saarbrücken Germany

S

Stephan Scholl

Institute for Chemical and Thermal Process Engineering Technische Universität Braunschweig Braunschweig Germany

J

Joachim Venus

Department of Bioengineering Leibniz Institute for Agricultural Engineering and Bioeconomy (ATB) Potsdam Germany

C

Christoph Wittmann

Institute of Systems Biotechnology Saarland University Saarbrücken Germany

Funding

Bundesministerium für Bildung und Forschung Award: 03V0757

Cite This Article

Jozef B. J. H. van Duuren, Paul J. de Wild, Sören Starck, et al. (2020). Limited life cycle and cost assessment for the bioconversion of lignin‐derived aromatics into adipic acid. Biotechnology and Bioengineering, 117(5), 1381-1393. https://doi.org/10.1002/bit.27299

Limited life cycle and cost assessment for the bioconversion of lignin‐derived aromatics into adipic acid

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