Effect of alpha‐lipoic acid supplementation on markers of protein oxidation in post‐mitotic tissues of ageing rat

Refik Kayali; Ufuk Çakatay; Tülay Akçay; Tuncay Altuğ

doi:10.1002/cbf.1190

journal article Nov 08, 2004

Effect of alpha‐lipoic acid supplementation on markers of protein oxidation in post‐mitotic tissues of ageing rat

Refik Kayali Ufuk Çakatay Tülay Akçay Tuncay Altuğ

Cell Biochemistry and Function Vol. 24 No. 1 pp. 79-85 · Wiley

View at Publisher Save 10.1002/cbf.1190

Abstract

AbstractIn the present study, we investigated whether DL‐α‐lipoic acid (LA) supplementation could have prooxidant or antioxidant effects on oxidative protein damage parameters such as protein carbonyl (PCO), nitrotyrosine (NT), advanced oxidation protein products (AOPP), and protein thiol (P‐SH), as well as oxidative stress parameters such as total thiol (T‐SH), non‐protein thiol (Np‐SH), and lipid hydroperoxide (LHP) in the brain and the skeletal muscle tissue of aged rats. PCO, and NT levels were increased, AOPP and P‐SH levels were not changed in the brain tissue of aged rats given LA supplementation. On the other hand, TSH, Np‐SH, and LHP levels were decreased in the brain tissue of aged rats given LA supplementation. The levels of the same parameters were not significantly different in the skeletal muscle tissue of aged rats given LA supplementation. The increased levels of protein oxidation markers such as PCO, and NT in the brain tissue of LA‐supplemented aged rats compared with non‐supplemented aged rats may suggest that oxidative protein damage is increased in LA‐supplemented aged rats. We assume that an explanation for our findings regarding LA supplementation on protein oxidation markers in the brain tissue of aged rats may be due to the prooxidant effects of LA. Depending on post‐mitotic tissue type and dosage of LA, the prooxidant effects of LA supplementation, should be considered in future studies. Copyright © 2004 John Wiley & Sons, Ltd.

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Published: Nov 08, 2004
Vol/Issue: 24(1)
Pages: 79-85
License: View

Authors

Cite This Article

Refik Kayali, Ufuk Çakatay, Tülay Akçay, et al. (2004). Effect of alpha‐lipoic acid supplementation on markers of protein oxidation in post‐mitotic tissues of ageing rat. Cell Biochemistry and Function, 24(1), 79-85. https://doi.org/10.1002/cbf.1190

Effect of alpha‐lipoic acid supplementation on markers of protein oxidation in post‐mitotic tissues of ageing rat

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