Structure of PD1 and its mechanism in the treatment of autoimmune diseases

Mahdi Rezayi; Arezoo Hosseini

doi:10.1002/cbf.3827

journal article Jul 20, 2023

Structure of PD1 and its mechanism in the treatment of autoimmune diseases

Mahdi Rezayi Arezoo Hosseini

Cell Biochemistry and Function Vol. 41 No. 7 pp. 726-737 · Wiley

View at Publisher Save 10.1002/cbf.3827

Abstract

AbstractPD‐1 and CTLA‐4 can play an important role in addressing the issue of autoimmune diseases. PD‐1 is a transmembrane glycoprotein expressed on T, B, and Dentric cells. This molecule functions as a checkpoint in T cell proliferation. Ligation of PD‐1 with its ligands inhibits the production of IL‐2, IL‐7, IL‐10, and IL‐12 as well as other cytokines by macrophages, natural killer (NK) cells, and T cells, which can suppress cell proliferation and inflammation. Today, scientists attempt to protect against autoimmune diseases by PD‐1 inhibitory signals. In this review, we discuss the structure, expression, and signaling pathway of PD‐1. In addition, we discuss the importance of PD‐1 in regulating several autoimmune diseases, reflecting how manipulating this molecule can be an effective method in the immunotherapy of some autoimmune diseases.

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Details

Published: Jul 20, 2023
Vol/Issue: 41(7)
Pages: 726-737
License: View

Authors

M

Mahdi Rezayi

Department of Medical Sciences, Marand Baranch Islamic Azad University Marand Iran

A

Arezoo Hosseini

Cellular and Molecular Research Center, Cellular and Molecular Medicine Research Institute Urmia University of Medical Sciences Urmia Iran

Cite This Article

Mahdi Rezayi, Arezoo Hosseini (2023). Structure of PD1 and its mechanism in the treatment of autoimmune diseases. Cell Biochemistry and Function, 41(7), 726-737. https://doi.org/10.1002/cbf.3827

Structure of PD1 and its mechanism in the treatment of autoimmune diseases

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