Coleus vettiveroides ethanolic root extract protects against thioacetamide‐induced acute liver injury in rats

Kadmad Abdul Hameed Mohamed Azar; Devaraj Ezhilarasan; Karthik Shree Harini; Munusamy Karthick; Mani Uthirappan

doi:10.1002/cbf.3839

journal article Aug 21, 2023

Coleus vettiveroides ethanolic root extract protects against thioacetamide‐induced acute liver injury in rats

Kadmad Abdul Hameed Mohamed Azar Devaraj Ezhilarasan

Karthik Shree Harini

Munusamy Karthick Mani Uthirappan

Cell Biochemistry and Function Vol. 41 No. 7 pp. 876-888 · Wiley

View at Publisher Save 10.1002/cbf.3839

Abstract

AbstractAcute liver injury is caused by various factors, including oxidative stress and inflammation. Coleus vettiveroides, an ayurvedic medicinal plant, is known to possess antioxidant, antibacterial, and antidiabetic properties. In this current study, we investigated the protective effect of C. vettiveroides ethanolic root extract (CVERE) against thioacetamide (TAA)‐induced acute liver injury in rats. A single dose of TAA (300 mg/kg, b.w., i.p.) was administered to induce acute liver injury. The treatment groups of rats were concurrently treated with CVERE (125 and 250 mg/kg, b.w., p.o.) and silymarin (100 mg/kg, b.w., p.o.), respectively. After 24 h of the experimental period, TAA‐induced liver injury was confirmed by increased activity of serum transaminases and malondialdehyde levels in liver tissue, decreased levels of antioxidants, upregulated expression of the inflammatory marker gene, and altered liver morphology. Whereas CVERE simultaneous treatment inhibited hepatic injury and prevented the elevation of serum aspartate and alanine transaminases, alkaline phosphatase, and lactate dehydrogenase activities. CVERE attenuated TAA‐induced oxidative stress by suppressing lipid peroxidation and restoring antioxidants such as superoxide dismutase, catalase, and reduced glutathione. Further, CVERE treatment was found to inhibit nuclear factor κB‐mediated inflammatory signaling, as indicated by downregulated pro‐inflammatory cytokines including tumor necrosis factor‐α and interleukin‐1β. Our findings suggest that CVERE prevents TAA‐induced acute liver injury by targeting oxidative stress and inflammation.

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Details

Published: Aug 21, 2023
Vol/Issue: 41(7)
Pages: 876-888
License: View

Authors

K

Kadmad Abdul Hameed Mohamed Azar

Department of Pharmacology Koppal Institute of Medical Sciences Koppal Karnataka India

D

Devaraj Ezhilarasan

Department of Pharmacology, Saveetha Dental College Saveetha Institute of Medical and Technical Sciences (SIMATS) Chennai Tamil Nadu India

K

Karthik Shree Harini

Department of Pharmacology, Saveetha Dental College Saveetha Institute of Medical and Technical Sciences (SIMATS) Chennai Tamil Nadu India

M

Munusamy Karthick

Department of Pharmacology, Saveetha Dental College Saveetha Institute of Medical and Technical Sciences (SIMATS) Chennai Tamil Nadu India

M

Mani Uthirappan

Animal House Division CSIR‐Central Leather Research Institute, Adyar Chennai Tamil Nadu India

Cite This Article

Kadmad Abdul Hameed Mohamed Azar, Devaraj Ezhilarasan, Karthik Shree Harini, et al. (2023). Coleus vettiveroides ethanolic root extract protects against thioacetamide‐induced acute liver injury in rats. Cell Biochemistry and Function, 41(7), 876-888. https://doi.org/10.1002/cbf.3839

Coleus vettiveroides ethanolic root extract protects against thioacetamide‐induced acute liver injury in rats

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