Mammalian axoneme central pair complex proteins: Broader roles revealed by gene knockout phenotypes

Maria E. Teves; David R. Nagarkatti‐Gude; Zhibing Zhang; Jerome F. Strauss

doi:10.1002/cm.21271

journal article Jan 01, 2016

Mammalian axoneme central pair complex proteins: Broader roles revealed by gene knockout phenotypes

Maria E. Teves David R. Nagarkatti‐Gude Zhibing Zhang

Jerome F. Strauss

Cytoskeleton Vol. 73 No. 1 pp. 3-22 · Wiley

View at Publisher Save 10.1002/cm.21271

Abstract

The axoneme genes, their encoded proteins, their functions and the structures they form are largely conserved across species. Much of our knowledge of the function and structure of axoneme proteins in cilia and flagella is derived from studies on model organisms like the green algae, Chlamydomonas reinhardtii. The core structure of cilia and flagella is the axoneme, which in most motile cilia and flagella contains a 9 + 2 configuration of microtubules. The two central microtubules are the scaffold of the central pair complex (CPC). Mutations that disrupt CPC genes in Chlamydomonas and other model organisms result in defects in assembly, stability and function of the axoneme, leading to flagellar motility defects. However, targeted mutations generated in mice in the orthologous CPC genes have revealed significant differences in phenotypes of mutants compared to Chlamydomonas. Here we review observations that support the concept of cell‐type specific roles for the CPC genes in mice, and an expanded repertoire of functions for the products of these genes in cilia, including non‐motile cilia, and other microtubule‐associated cellular functions. © 2016 Wiley Periodicals, Inc.

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Details

Published: Jan 01, 2016
Vol/Issue: 73(1)
Pages: 3-22
License: View

Authors

M

Maria E. Teves

Department of Obstetrics and Gynecology Virginia Commonwealth University Richmond Virginia

D

David R. Nagarkatti‐Gude

Department of Obstetrics and Gynecology Virginia Commonwealth University Richmond Virginia; Department of Biochemistry and Molecular Biology Virginia Commonwealth University Richmond Virginia

Z

Zhibing Zhang

Department of Obstetrics and Gynecology Virginia Commonwealth University Richmond Virginia; Department of Biochemistry and Molecular Biology Virginia Commonwealth University Richmond Virginia

J

Jerome F. Strauss

Department of Obstetrics and Gynecology Virginia Commonwealth University Richmond Virginia; Department of Biochemistry and Molecular Biology Virginia Commonwealth University Richmond Virginia

Funding

National Institutes of Health Award: R01HD076257

National Institute of Child Health and Human Development Award: 5F31HD062314

Cite This Article

Maria E. Teves, David R. Nagarkatti‐Gude, Zhibing Zhang, et al. (2016). Mammalian axoneme central pair complex proteins: Broader roles revealed by gene knockout phenotypes. Cytoskeleton, 73(1), 3-22. https://doi.org/10.1002/cm.21271

Mammalian axoneme central pair complex proteins: Broader roles revealed by gene knockout phenotypes

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